A5027603772- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Vasculitis and related conditions
- Nephrotoxicity and Medicinal Plants
- Mesenchymal stem cell research
- Magnesium in Health and Disease
- Cell Adhesion Molecules Research
- Lipid metabolism and disorders
- Virus-based gene therapy research
- Apelin-related biomedical research
- Biomedical Research and Pathophysiology
- Metabolism, Diabetes, and Cancer
- Moyamoya disease diagnosis and treatment
- Advanced Glycation End Products research
- Neurological Complications and Syndromes
- Genetic Syndromes and Imprinting
- Genetic and Kidney Cyst Diseases
- Sirtuins and Resveratrol in Medicine
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- Chemotherapy-induced organ toxicity mitigation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neurogenesis and neuroplasticity mechanisms
Army Medical University
2012-2022
Xinqiao Hospital
2012-2022
Peking Union Medical College Hospital
1995
Chinese Academy of Medical Sciences & Peking Union Medical College
1995
Mesenchymal stem cells (MSC) attenuate albuminuria and preserve normal renal histology in diabetic mice. However, the effects of MSC on glomerular podocyte injury remain uncertain. The aim this study was to evaluate streptozotocin (STZ)-induced rats. Thirty days after diabetes induction by STZ injection (65 mg/kg, intraperitoneally) Sprague-Dawley rats, rats received medium or 2 × 106 enhanced green fluorescent protein-labeled via artery. In vivo tracking followed immunofluorescence...
Abstract Increased basic fibroblast growth factor‐2 ( FGF2 ) and reduced Klotho have both been reported to be closely associated with renal fibrosis. However, the relationship between remains unclear. We demonstrate that induced tubulo‐epithelial plasticity in cultured HK ‐2 cells, accompanied by a reduction expression, whereas recombinant protein could inhibit action of . The effects required extracellular signal‐regulated kinase 1/2 activation, which was suppressed Klotho. Moreover, also...
Hyperuricemia is an independent risk factor for causing chronic kidney disease and contributes to fibrosis. After urate crystals get deposited in the kidney, they can cause hyperuricemia nephropathy, leading glomerular hypertrophy renal tubular interstitial Recent data showed that uric acid (UA) could induce epithelial mesenchymal transition (EMT) of cells, which NRLP3 inflammatory pathway was involved. However, whether TLR4/NF-κB signaling also involved EMT cells induced by UA not clear.
Background/Aims: Hyperphosphatemia is one of the most notable features chronic kidney disease (CKD). Numerous epidemiological and clinical studies have found that high serum phosphate concentrations are associated with calcification in coronary arteries. However, mechanisms underlying vascular induced by not been understood fully. Methods: Vascular smooth muscle cells (VSMCs) were cultured high-phosphate media to induce calcification, which was detected Alizarin red S staining. Gene...
Few studies have analyzed the clinicopathologic characteristics and outcomes of lupus nephritis (LN) patients with antineutrophil cytoplasmic antibody (ANCA). The clinical renal histopathologic data 154 biopsy-proven LN from 2011 to 2013 were retrospectively. followed up for a median period 16.8 ± 9.4 months, their analyzed. Multivariate Cox analysis was used evaluate independent factors poor outcomes. Among patients, 26 (16.88%) seropositive ANCA. incidences alopecia, oral ulcer,...
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterised by the autoinflammation and necrosis of blood vessel walls. The renal involvement commonly a pauci-immune crescentic glomerulonephritis (PiCGN) with very rapid decline in function. Cathelicidin LL37, an endogenous antimicrobial peptide, has recently been implicated pathogenesis autoimmune diseases. To assess whether serum LL37 reflects formation, we measured levels AAV patients without (crescentic GN) as...
Although the key role of renal fibrosis in progression chronic kidney disease (CKD) is well known, causes are not fully clarified. In this study, interferon regulatory factor 1 (IRF-1), a mammalian transcription factor, was highly expressed fibrotic CKD patients. Concordantly, expression level IRF-1 significantly elevated unilateral ureteral obstruction (UUO) and Adriamycin nephropathy (ADR) mice. tubular epithelial cells, overexpression could induce profibrotic markers expression, which...
The aim of this study was to investigate the influence long non-coding ribonucleic acid (lncRNA) urothelial carcinoma associated 1 (UCA1) on glucose metabolism in rats with diabetic nephropathy (DN), and explore its regulatory mechanism.A total 30 healthy Sprague-Dawley (SD) were selected study. All randomly divided into three groups, including control group, model lncRNA UCA1 inhibitor group. rat DN successfully established via intraperitoneal injection streptozotocin (STZ). pathological...