A5100650893- Medical Imaging Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Advanced Glycation End Products research
- Advanced MRI Techniques and Applications
- Adipose Tissue and Metabolism
- Advanced X-ray and CT Imaging
- Cancer-related gene regulation
- ATP Synthase and ATPases Research
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Radiomics and Machine Learning in Medical Imaging
- Drug Transport and Resistance Mechanisms
- Rangeland Management and Livestock Ecology
- MicroRNA in disease regulation
- Chronic Kidney Disease and Diabetes
- Epigenetics and DNA Methylation
- Dialysis and Renal Disease Management
- Stress Responses and Cortisol
- Cancer, Hypoxia, and Metabolism
- Medical Research and Treatments
- Aldose Reductase and Taurine
- Coenzyme Q10 studies and effects
- Kruppel-like factors research
- Cholesterol and Lipid Metabolism
Central South University of Forestry and Technology
2022
Central South University
2022
Chengdu University of Technology
2022
Guangzhou University
2022
Xinqiao Hospital
2006-2020
Army Medical University
2006-2020
University of Pittsburgh
2019
Beijing Normal University
2019
Air Force Medical University
2015
Zero to Three
2011
Epigenetics plays a key role in the pathogenesis of diabetic nephropathy (DN), although precise regulatory mechanism is still unclear. Here, we examined endoplasmic reticulum (ER) stress histone H3 lysine 4 (H3K4) methyltransferase SET7/9-induced monocyte chemoattractant protein-1 (MCP-1) expression kidneys db/db mice. Our results indicate that MCP-1 significantly increased mice time-dependent manner. An chromatin mark associated with an active gene (H3K4me1) at promoters accompanied this...
Mesangial cell (MC) phenotypic transition is crucial for the progression of diabetic nephropathy. A major stimulus mediating high glucose-induced MC TGF-β1. Our current study focuses on microRNA-215 (miR-215) and investigates its role in TGF-β1-mediated transition. Using real-time quantitative PCR (qRT-PCR) northern blotting, we determined that miR-192/215 family dramatically upregulated under conditions both vitro vivo. Gain- loss-of-function approaches demonstrated miR-215 inhibition...
BACKGROUND At present, the incidence of diabetic nephropathy is increasing year by year, and there are many studies on pathogenesis nephropathy, but it still not completely clear. The final pathological result mainly glomerular cell fibrosis, roles micro-RNA (miRNA)-29 DNA methyl transferase (DNMTs) in fibrosis have been confirmed other studies, a lack relevant research kidney at present. AIM To study potential involvement miRNA-29a-3p related to disease (DKD). METHODS expression miR-29a-3p,...
The activation of Translocator protein (18 kDa) (TSPO) has been demonstrated to mediate rapid anxiolytic efficacy in stress response and stress-related disorders. This is involved the synthesis endogenous neurosteroids that promote γ-aminobutyric acid (GABA)-mediated neurotransmission central neural system. However, little known about functions underlying mechanisms TSPO chronic pain-induced anxiety-like behaviors. novel ligand...
Inflammation plays a central role in the pathogenesis of atherosclerosis. This study investigated whether proteasome inhibitor has same preventive effect on formation accelerated atherosclerosis rabbits with uremia compared NF-κB inhibitor. New Zealand white were subjected to five-sixths nephrectomy (chronic renal failure [CRF]) or sham operation. Rats each group randomly assigned into three subgroups (n = 24 group) and treated repeated intramuscular injections MG132 PDTC for specified...
Abstract Diabetic nephropathy (DN), the leading cause of end-stage renal disease (ESRD). To date, mounting evidence has shown that inflammation may contribute to pathogenesis DN. Recent reports have proteasome inhibitors display cytoprotection by reducing phosphorylation Akt, a serine/threonine kinase, plays critical role in cellular survival and metabolism can crosstalk with inflammation. Therefore, we hypothesized MG132, specific inhibitor, could provide renoprotection suppressing...
The ubiquitin-proteasome pathway (UPP) has been indicated to contribute dysfunction of endothelial cells (ECs). Nevertheless, the relationship between UPP and vascular complications uraemia remains unknown. We aimed determine whether is activated in ECs when cultured with uraemic serum, examine role on uraemia. Rabbit aortic (RAECs) were normal serum or different concentrations serum. expression ubiquitin-activating enzyme (E1), an indicator UPP, was detected by real-time RT-PCR Western...
In order to reconstruct attenuation maps with improved spatial resolution and quantitative accuracy, we developed an approximate method of incorporating system compensation (RC) in the ordered-subset transmission (OSTR) algorithm for reconstruction. Our approximately models blur caused by finite intrinsic detector resolution, nonideal source collimation collimation. We derived formulation using optimization transfer principle as derivation OSTR algorithm. The includes one forward-blur step...
The ubiquitin‑proteasome pathway (UPP) is involved in the occurrence and development of atherosclerosis through inhibitor κB (IκB) degradation which activates nuclear factor-κB (NF‑κB). However, correlation between UPP vascular complications uramia remains unknown. aim present study was to determine whether activated aortic smooth muscle cells (ASMCs) when cultured with uremic serum examine role on dysfunction ASMCs uremia. were pooled normal sera or chronic renal failure sera. mRNA...
The goal of these investigations was to develop a rapid transmission imaging method for estimating truncation-free attenuation maps in cardiac SPECT without mechanical motion the sources. We conducted both theoretical and experimental cone-beam imaging. studies were evaluate various gantry configurations determine axial extent asymmetric region which could be reconstructed significant artifacts. performed using two Ba-133 point sources Beacon scanning point-source system on our Philips...
Patient motion during cardiac SPECT imaging can cause diagnostic artifacts. We have implemented a neural network (NN) approach to decompose monitored patient data, gathered imaging, using the Polaris stereo-IR real-time motion-tracking system with stated 0.35 mm accuracy and 0.2 repeatability. In our earlier work we obtained excellent correlation (R2>0.998) of axial vertical target position as measured by Polaris. also correlate volunteer respiration data from pneumatic bellows similarly...