A5100392256- Telomeres, Telomerase, and Senescence
- Genetics, Aging, and Longevity in Model Organisms
- DNA Repair Mechanisms
- Plant Virus Research Studies
- Insect Resistance and Genetics
- Nuclear Structure and Function
- RNA Interference and Gene Delivery
- Single-cell and spatial transcriptomics
- Genomics and Rare Diseases
- Caveolin-1 and cellular processes
- Genomics and Chromatin Dynamics
- Plant Parasitism and Resistance
- Invertebrate Immune Response Mechanisms
- Signaling Pathways in Disease
- Mosquito-borne diseases and control
- RNA Research and Splicing
- Legume Nitrogen Fixing Symbiosis
- Insect Utilization and Effects
- Cancer Genomics and Diagnostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Insect-Plant Interactions and Control
- RNA regulation and disease
Chinese Academy of Sciences
2014-2023
Institute of Zoology
2014-2023
University of Chinese Academy of Sciences
2018-2023
Institute of Biophysics
2018-2021
Inactivation of the histone acetyltransferase gene KAT7 prolongs survival in naturally aged mice and progeroid that age prematurely.
Aging increases the risk of various diseases. The main goal aging research is to find therapies that attenuate and alleviate aging-related In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), premature model recently established. Ten candidate were identified quercetin was investigated in detail due its leading effects. Mechanistic studies revealed alleviated senescence via enhancement cell...
Hutchinson-Gilford progeria syndrome (HGPS) and Werner (WS) are two of the best characterized human progeroid syndromes. HGPS is caused by a point mutation in lamin A (LMNA) gene, resulting production truncated protein product—progerin. WS mutations WRN encoding loss-of-function RecQ DNA helicase. Here, gene editing we created isogenic embryonic stem cells (ESCs) with heterozygous (G608G/+) or homozygous (G608G/G608G) LMNA biallelic knockout, for modeling pathogenesis, respectively. While...
Viral diseases seriously threaten rice production. Plasmodesmata (PD)-associated proteins are deemed to play a key role in viral infection host plants. However, few PD-associated have been discovered afford infection. Here, inspired by the mechanism insect vectors, we identified member of Flotillin family taking part cell-to-cell transport stripe virus (RSV) rice. Flotillin1 interacted with RSV nucleocapsid protein (NP) and was localized on PD. In flotillin1 knockout mutant rice, which...