A5101765982- Renal and Vascular Pathologies
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Kidney Stones and Urolithiasis Treatments
- MRI in cancer diagnosis
- Abdominal vascular conditions and treatments
- Pediatric Urology and Nephrology Studies
- Vascular Procedures and Complications
- Porphyrin Metabolism and Disorders
- Cardiac Arrest and Resuscitation
- Acute Ischemic Stroke Management
- Radiopharmaceutical Chemistry and Applications
- Advanced X-ray and CT Imaging
- Hemodynamic Monitoring and Therapy
- Biomedical Research and Pathophysiology
- Cardiovascular Health and Disease Prevention
- Sepsis Diagnosis and Treatment
- Renal cell carcinoma treatment
- Mesenchymal stem cell research
- Aortic aneurysm repair treatments
- Analytical Methods in Pharmaceuticals
- Antibiotics Pharmacokinetics and Efficacy
- Advanced MRI Techniques and Applications
- Acute Kidney Injury Research
- Urological Disorders and Treatments
Second Hospital of Anhui Medical University
2012-2025
Anhui Medical University
2012-2025
Rutgers, The State University of New Jersey
2000-2025
Peking University First Hospital
2016-2025
Peking University
2016-2025
Shandong University
2015-2024
Sichuan University
2012-2024
West China Hospital of Sichuan University
2012-2024
North Sichuan Medical University
2024
Hunan Children's Hospital
2024
To investigate whether addition of three different doses liraglutide to insulin in patients with type 1 diabetes (T1D) results significant reduction glycemia, body weight, and dose.We randomized 72 (placebo = 18, 54) T1D receive placebo 0.6, 1.2, 1.8 mg daily for 12 weeks.In the 1.2-mg 1.8-mg groups, mean weekly average blood glucose was -0.55 ± 0.11 mmol/L (10 2 mg/dL) 0.05 mg/dL), respectively (P < 0.0001), while it remained unchanged 0.6-mg groups. In group, HbA1c fell significantly...
Crohn's disease (CD) and peripheral arterial (PAD) are closely related. The pathophysiological mechanisms underlying the coexistence of CD PAD unknown. aim this study was to investigate key molecules pathways mediating co-occurrence through quantitative bioinformatic analysis a public RNA sequencing database.Datasets (GSE111889) (GSE120642) were downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) analyzed using 'edgeR' 'limma' packages R. Ontology...
Abstract Background Mesenchymal stem cells (MSCs) can improve limb perfusion and increase vessel density in a murine model of hindlimb ischemia. But low engraftment rate those limited their therapeutic effect. Endothelial (ECs) play an important role neovascularization. And MSCs differentiate into ECs vitro. The aim this study is to investigate if EC differentiation vitro before transplantation effective improving outcomes the treatment ischemic disease ischemia animal model. Methods were...
Objective To evaluate the long-term efficacy and safety of selective arterial embolization (SAE) in treatment renal angiomyolipomas (AMLs). Methods This was a retrospective review medical records imaging findings from patients with AMLs who attended our clinic received SAE between January 2007 2014. Only patents complete records, preoperative computed tomography scans using typical follow-up data were included. Results A total 79 enrolled study. Technical clinical success rates 100% 91% ( n...
Abstract Cystinuria is a rare genetic disorder characterized by defective l -cystine reabsorption from the renal proximal tubule, resulting in abnormally high concentrations of L-cystine and subsequent crystallization stone formation urine. -Cystine diamides have shown great promise as inhibitors crystallization. The free α-amino groups previously been to be necessary for inhibitory activity. In this study, three additional series diamide analogs were designed explore further...
The purpose of this study was to evaluate the efficacy and safety transarterial embolization (TAE) for iatrogenic renal arterial pseudoaneurysm arteriovenous fistula at our center. Our retrospective analysis included 27 patients who received TAE between January 2006 2016. Data on demographics, type minimally invasive procedures, clinical manifestation, imaging features, procedure, perioperative details were collected. technical success rates analyzed. Furthermore, changes in serum creatinine...
l-Cystine bismorpholide (1a) and l-cystine bis(N'-methylpiperazide) (1b) were seven twenty-four times more effective than dimethyl ester (CDME) in increasing the metastable supersaturation range of l-cystine, respectively, effectively inhibiting crystallization. This behavior can be attributed to inhibition crystal growth at microscopic length scale, as revealed by atomic force microscopy. Both 1a 1b are stable CDME, was vivo a knockout mouse model cystinuria.
Abstract Background The effects of diastolic arterial pressure (DAP) and heart rate (HR) on the prognosis patients with septic shock are unclear, whether these persist over time is unknown. We aimed to investigate relationship between exposure different intensities DAP HR mortality at 28 days in shock. Methods In this cohort study, we obtained data from Medical Information Mart for Intensive Care IV, which includes adult (≥ 18 years) who underwent invasive blood monitoring. excluded received...
To investigate whether the use of diabetes registries meeting Meaningful Use core objectives in primary care practices is associated with differences quality and hospital utilization rates.A practice assessment survey was conducted to identify how were using registries. Insurance claims data from 2010 used compare health outcomes patients that Use-related other practices. Logistic hierarchical linear modeling analyze data.Records 12,514 diabetic (including 10,809 type 2 diabetes) 50 urban...
This study aimed to comprehensively evaluate non-contrast computed tomography (CT)-based radiomics for predicting early outcomes in patients with severe atherosclerotic renal artery stenosis (ARAS) after percutaneous transluminal angioplasty (PTRA). A total of 52 were retrospectively recruited, and their clinical characteristics pretreatment CT images collected. During a median follow-up period 3.7 mo, 18 confirmed have benefited from the treatment, defined as 20% improvement baseline...
Cystinuria, a rare genetic disorder, is characterized by defective l-cystine reabsorption from the renal proximal tubule, resulting in abnormally high concentrations of and subsequent crystallization urine stone formation urinary tract. Inhibition diamides such as LH708 (2) represents promising new approach to prevent patients with cystinuria. While 2 shows vivo efficacy good safety profile Slc3a1-knockout mouse model cystinuria, further structural modification led discovery 8-l-cystinyl...
Abstract A high‐performance liquid chromatography method with fluorescence detection (HPLC‐FLD) for the determination of levofloxacin in human plasma is described. Neutralized phosphate buffer (pH 7.0), sample (0.1 mL) was extracted dichlormethane (1 mL). After voltex‐mixing and centrifuged at 3000 g 6 min 4°C, upper aqueous layer aspirated using a micro vacuum pump organic directly transferred to clean test tube without pipetting. The solvent evaporated residues were reconstituted mobile...