A5032914084- Renal and Vascular Pathologies
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- Tuberous Sclerosis Complex Research
- Endometriosis Research and Treatment
- Hydrogen Storage and Materials
- Enterobacteriaceae and Cronobacter Research
- Epigenetics and DNA Methylation
- Computational Drug Discovery Methods
- Pediatric Urology and Nephrology Studies
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Vasculitis and related conditions
- Medical Imaging and Pathology Studies
- Neuroendocrine Tumor Research Advances
- Macrophage Migration Inhibitory Factor
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
Sun Yat-sen University
2020-2024
Sun Yat-sen University Cancer Center
2020-2024
State Key Laboratory of Oncology in South China
2020-2022
Peking University
2018-2022
Peking University First Hospital
2018-2022
<p>A reliable system for dynamic prognostication and management of hepatocellular carcinoma (HCC) is urgently needed but currently unavailable. In our previous work, we developed a machine learning algorithm termed "Survival Path" (raw-SP) to enhance with longitudinal survival data. However, the model was limited intermediate stage HCC patients, it faced risk overfitting due path proliferation. this study, novel framework incorporating nodal fusion techniques mitigate overfitting,...
Hepatocellular carcinoma (HCC) has a high incidence and mortality rate despite various treatment options, including 125I seed implantation. However, recurrence radiation resistance remain challenging issues. Hsa_circ_0007895 (circEYA3)-derived from exons 2-6 of EYA3-facilitates the proliferation progression pancreatic ductal adenocarcinoma. role circEYA3 in HCC remains unclear. Thus, we aimed to investigate functions underlying molecular mechanisms under X-ray irradiation conditions.CircEYA3...
Abstract The relative abundance of myeloid‐derived suppressor cells (MDSCs) compared to cytotoxic T determines the outcomes diseases and efficacy immunotherapy. Ubiquitin‐specific peptidase 12 (USP12), a member USP family deubiquitinases, targets multiple signalling pathways regulates diverse biological processes, including cell proliferation survival. It is well known that ubiquitylation an important mechanism for regulating immune response. However, it unclear whether USP12 tumour growth...
Liver hepatocellular carcinoma (LIHC), one of the most common primary malignancies, exhibits high levels molecular and clinical heterogeneity. Increasing evidence has confirmed important roles some RNA helicase families in tumor development, but function DEAH-box family LIHC therapeutic strategies not yet been clarified.The dataset was downloaded from The Cancer Genome Atlas (TCGA). Consensus clustering applied to group patients. Least absolute shrinkage selection operator Cox regression...
This study used contrast-enhanced ultrasound (CEUS) to evaluate changes in renal cortical blood perfusion after percutaneous transluminal angioplasty and stenting (PTRAS) for severe artery stenosis (RAS) (≥70%). CEUS was performed 21 patients with 24 RASs that underwent PTRAS. Renal quantitatively evaluated by comparing time intensity curve (TIC) parameters SonoVue (Bracco, Milan, Italy) contrast enhancement, including peak (PI), (TTP), mean transmit (MTT), ascending slope (S), area under...
BACKGROUND: Atherosclerotic renal artery stenosis (ARAS) is a common disease in the elderly population. OBJECTIVE: The aim was to develop contrast-enhanced ultrasound (CEUS)-based model for predicting post-angioplasty improvement hypertension patients with severe ARAS. METHODS: Thirty-five ARAS (⩾ 70%) were included this study, and 42 arteries received percutaneous transluminal arterial stenting. An optimal integral formula developed from pre-interventional color-coded duplex sonography...
The discrepancy between the high technical success rate and relatively low clinical response of renal artery stenting (RAS) raises importance to identify atherosclerotic stenosis (ARAS) patients who are most likely benefit from RAS. This study aimed investigate feasibility accuracy blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) in predicting split function (SRF) improvement after RAS with ARAS.Thirty severe ARAS were treated enrolled. Baseline cortical medullary R2*...
e14644 Background: This study aimed to retrospectively evaluate the efficacy of ablation combined with programmed cell death protein 1 (PD-1) inhibitor versus PD-1 monotherapy in patients liver metastasis. Methods: We enrolled metastasis who received therapy or without at three medical institutions between January 2017 and September 2022. Progression-free survival (PFS) 1-year rates were compared after propensity score matching. Additionally, intrahepatic extrahepatic lesion progression...
Radioactive iodine-125 (
Ionizing radiation (IR) is an important treatment for nasopharyngeal carcinoma (NPC) that mainly kills tumor cells by producing large amounts of reactive oxygen species (ROS). Intracellular ROS levels affect the sensitivity to IR. Recently, angiotensin-converting enzyme inhibitors (ACEIs) and (ACE) have been found intracellular ROS. Therefore, we performed a health informatics assessment ACE in TCGA database. We explored effect NPC cells. either knockdown or inhibition enalaprilat could...
The aim of this study was to compare the effectiveness and outcomes percutaneous ablation guided by ultrasonography (US) computed tomography (CT) in colorectal liver oligometastases (CLOM).This included patients with CLOM treated from January 2008 2021 observational study. Only lesions visualized on both CT US images were further analyzed according whether patients' initial treatments utilized guidance or guidance. Kaplan-Meier method used estimate local tumor progression (LTP)-free survival...
To determine if dynamic CT can differentiate local progression from radioactive seed-induced peritumoral reaction (RSIPR) after brachytherapy with iodine-125 seeds (BIRS) for advanced hepatic malignancies.Enhanced images of seed-implanted lesions between 2006 and 2018 were retrospectively evaluated. Hounsfield units parenchyma measured assessed quantitatively. The classification, conversion, consequences, serological indicators during follow-up recorded quantified. Statistical differences...