A5051809701- Liver Disease Diagnosis and Treatment
- Biochemical and Molecular Research
- Synthesis and biological activity
- Porphyrin Metabolism and Disorders
- Bacteriophages and microbial interactions
- Biomedical Research and Pathophysiology
- Folate and B Vitamins Research
- Cholesterol and Lipid Metabolism
- Veterinary medicine and infectious diseases
- Kidney Stones and Urolithiasis Treatments
- Diet, Metabolism, and Disease
- Liver Diseases and Immunity
- Antimicrobial Peptides and Activities
- Amino Acid Enzymes and Metabolism
- Virus-based gene therapy research
- Fibroblast Growth Factor Research
- Organic Chemistry Cycloaddition Reactions
- Synthesis of heterocyclic compounds
- Drug Transport and Resistance Mechanisms
- HIV/AIDS drug development and treatment
- Synthesis and Biological Evaluation
- Plant Virus Research Studies
- Lipid metabolism and disorders
- Microbial Natural Products and Biosynthesis
- Sulfur Compounds in Biology
Guilin Medical University
2015-2024
Rutgers, The State University of New Jersey
2024
Shanghai Institute of Pharmaceutical Industry
2012-2013
Abstract Cystinuria is a rare genetic disorder characterized by defective l -cystine reabsorption from the renal proximal tubule, resulting in abnormally high concentrations of L-cystine and subsequent crystallization stone formation urine. -Cystine diamides have shown great promise as inhibitors crystallization. The free α-amino groups previously been to be necessary for inhibitory activity. In this study, three additional series diamide analogs were designed explore further...
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic in clinical practice. This study examined effects of mulberry leaf aqueous extract (MLQE) on lipid metabolism and gut microbiota mice with high-fat diet-induced NAFLD. Using network pharmacology, we identified key targets stem's constituents for NAFLD regulation validated their ameliorative through animal experiments. Our results demonstrated that interventions orlistat (HFO), swimming exercise (HFS), MLQE (HFM)...
Coumarins are widely present in a variety of plants and have pharmacological activities. In this study, we isolated coumarin compound from Microsorium fortunei (Moore) Ching; the was identified as esculetin by hydrogen carbon spectroscopy. Its anti-hepatitis B virus (HBV) activity investigated vitro vivo. human hepatocellular liver carcinoma 2.2.15 cell line (HepG2.2.15) transfected with HBV, effecting inhibited expression HBV antigens DNA vitro. Esculetin Hepatitis X (HBx) protein...
Cystinuria, a rare genetic disorder, is characterized by defective l-cystine reabsorption from the renal proximal tubule, resulting in abnormally high concentrations of and subsequent crystallization urine stone formation urinary tract. Inhibition diamides such as LH708 (2) represents promising new approach to prevent patients with cystinuria. While 2 shows vivo efficacy good safety profile Slc3a1-knockout mouse model cystinuria, further structural modification led discovery 8-l-cystinyl...
The design and synthesis of a series substituted 6-amino-4-(2,4-dimethoxyphenyl)-[1,2]dithiolo[4,3-b]pyrrol-5-ones are described. All the synthesized compounds were evaluated for raising leukocyte count activities in normal mice. Four (8a, b, d, h) exhibited close or higher than positive control recombinant human granulocyte colony stimulating factor (rhG-CSF), some (8e-g, k, p, r) had moderate effect. Among them, most potent compound 8a was its antileukopenia activity cyclophosphamide (CTX)...
In this study, a series of amide derivatives were synthesized and evaluated for their S-adenosyl-L-homocysteine hydrolase (SAHase) inhibitory activities. The results demonstrated that most compounds displayed potent SAHase Interestingly, 11 14 exhibited more effects than the aristeromycin, one inhibitors known so far. Compounds 12, 13, 15 17 moderate effect (IC50<10.0 µM). structure-activity relationship found with substituted indazole-5-yl group at Ar position ethylamino side chain showed better
Background: Dyslipidemia is a serious threat to human health. The objective of our research was develop effective FXR antagonists against dyslipidemia. Methods: Herein we describe the design, synthesis 37 N-(5-(2,5-dimethylphenoxy)-2,2- dimethylpentyl)-benzamide derivatives and evaluated for their inhibition ability compared GS SIPI-7623. Results: Structure–activity relationship analyses indicated that compounds containing hydroxyl on right side phenyl were more than those without hydroxyl....
Fourteen novel compounds were prepared and their antagonistic activities against liver X receptors (LXR) α/β tested in vitro. Compound 26 had an IC50 value of 6.4 µM LXRα 5.6 LXRβ. Docking studies the results structure–activity relationships support further development this chemical series as LXRα/β antagonists.
Abstract A series of new title compounds (XIII), (XVI), (XVII) is synthesized.
Abstract Bacterial RNA polymerase (RNAP) is a validated drug target for broad‐spectrum antibiotics, and its “switch region” considered as the promising binding site novel antibiotics. Based on core scaffold of dithiolopyrrolone, series N ‐aryl pyrrothine derivatives was designed, synthesized, evaluated their antibacterial activity. Compounds generally displayed more active against Gram‐positive bacteria, but less Gram‐negative bacteria. Among them, compound 6e exhibited moderate activity...
Non-alcoholic steatohepatitis is a clinical syndrome with pathological changes similar to alcoholic without history of excessive alcohol consumption, and key stage reversible progression liver fibrosis, which can further develop into malignant diseases such as cirrhosis or even cancer if preventive measures are not taken. The pathogenesis NASH complex, there no any effective drugs for NASH. It difficult single-target achieve good therapeutic effects, accompanied by strong side many them...