A5101404833- ZnO doping and properties
- Copper-based nanomaterials and applications
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Gas Sensing Nanomaterials and Sensors
- Cardiovascular Issues in Pregnancy
- Circular RNAs in diseases
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Studies on Chitinases and Chitosanases
- RNA modifications and cancer
- Cancer-related gene regulation
- Gout, Hyperuricemia, Uric Acid
- Health Systems, Economic Evaluations, Quality of Life
- RNA Interference and Gene Delivery
- SARS-CoV-2 detection and testing
- Urological Disorders and Treatments
- Semiconductor materials and devices
- Cardiac Structural Anomalies and Repair
- Inflammation biomarkers and pathways
- Transition Metal Oxide Nanomaterials
- HVDC Systems and Fault Protection
- Mitochondrial Function and Pathology
Harbin Medical University
2024-2025
Second Affiliated Hospital of Harbin Medical University
2024-2025
Xiamen University
2023-2025
Ministry of Education of the People's Republic of China
2024
Beijing Anzhen Hospital
2022
Capital Medical University
2022
Dalian Medical University
2022
Chongqing Medical University
2022
Second Affiliated Hospital of Chongqing Medical University
2022
CCS Associates (United States)
2022
Tumor-derived extracellular vesicles (tEVs) are essential mediators of tumor progression and therapeutic resistance, yet their secretion dynamics cargo composition in response to therapies remain poorly understood. Here, we present STAMP, specific click-tagging driven by aptamer for tEV labeled with a metabolic timestamp, which exploits the unique kinetics thermodynamics significantly enhance local concentration clickable probes on tEVs covalent attachment resulting selective microfluidic...
<h3>Importance</h3> Despite advances in the treatment of ST-segment elevation myocardial infarction (STEMI), little is known about how this evolving knowledge applied current clinical practice China. <h3>Objective</h3> To evaluate hospital performance and temporal trends management STEMI. <h3>Design, Setting, Participants</h3> This study used data from Improving Care for Cardiovascular Disease China–Acute Coronary Syndrome Project, a nationwide quality improvement registry, collaboration...
Abstract The COVID‐19 pandemic, caused by SARS‐CoV‐2, has seriously threatened human life and security in recent years had a serious impact on economic development. A range of strategies, including antibodies, small‐molecule agents vaccines, have been developed widely used to combat SARS‐CoV‐2. However, the uncertain development susceptibility mutation SARS‐CoV‐2 pose challenges these approaches, making it necessary develop broader strategies complement expand diversity attacks against As...
Polycrystalline anatase Ti1−xCoxO2 (x=0–0.06) films have been fabricated by sol-gel spin coating. The effects of Co doping on the structural, optical, and magnetic properties are investigated. It is shown that oxygen vacancies and/or defects in generated during thermal treatment vacuum. reduces crystal quality inhibits crystalline grain growth. Due to introduction Co, photoluminescence (PL) spectra become weak band gap emission has a blueshift. PL reveal solubility lower than 0.02. At 300 K,...
Abstract Triggering receptor expressed on myeloid cells (TREM) has been broadly studied in inflammatory disease. However, the expression and function of TREM-2 remain undiscovered acquired cholesteatoma. The was significantly higher human cholesteatoma than normal skin from external auditory canal, its level positively correlated with severity bone destruction. Furthermore, mainly dendritic (DCs). In cholesteatoma, proinflammatory cytokines (IL-1β, TNF-α IL-6) matrix metalloproteinases...
Objectives/Hypothesis To investigate the simultaneous application of cartilage tympanoplasty combined with eustachian tube (ET) balloon dilatation in treatment adhesive otitis media (AdOM). Study Design Multicenter, prospective, double‐blind, randomized, controlled clinical trial. Methods Patients AdOM were randomly divided into four groups: control group (conservative treatment), ET (ETBD) group, (CT) and (ETBD+CT) group. followed up at 3 months, 6 1 year, 2 years after treatment, receiving...
Abstract Myocardial ischemia/reperfusion (I/R) injury greatly contributes to myocardial tissue damage in patients with coronary disease, which eventually leads heart failure. Long noncoding RNAs (lncRNAs) have an emerging role the process of I/R injury. Our previous work revealed protective miR‐374a‐5p against In this study, we explored lncRNA TTTY15 and its potential interaction mechanisms The expression was increased both vitro vivo after models according quantitative real‐time polymerase...
LC3B is a marker of autophagic activity, and growing evidence supports its importance in myocardial hypertrophy. Thus, regulating expression may provide an important avenue to inhibit autophagy protect against or pathological To address this question, we investigated the effects altering mRNA activity setting cardiomyocyte In vitro angiotensin II (Ang II)-induced hypertrophy model, protein was increased there activation autophagy, which assessed by transmission electron microscopy flow...
Objective: The aim of this study was to investigate whether MiR-30a regulates autophagy by regulating the Beclin-1 protein, which is marker for autophagosomes during myocardial injury, when induced angiotensin II (Ang II). Methods: We randomly assigned 20 rats into two equal groups: Control group and Ang group. detected expression quantitative real-time polymerase chain reaction (RT-PCR), we employed western blotting detect protein Beclin-1. Results: In study, found that cardiomyocyte...
Structural and magnetic properties of Fe-doped anatase TiO2 films fabricated by sol-gel spin coating are investigated. X-ray diffraction measurements reveal that Fe ions incorporated into the lattice. No ferromagnetism-related secondary phases nanoparticles observed in films. The presence electron paramagnetic resonance signals at g ∼ 2.0 supports oxygen vacancies and/or defects generated after annealing vacuum. Magnetic indicate ferromagnetic room temperature. These observations suggest...
Abstract To investigate the correlation between uric acid (UA) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels coronary artery severity in acute syndrome patients of different sexes. A total 134 with (ACS) were investigated. According to sex, there 96 cases male group 38 female group. number diseased vessels, degree lesion was determined divided into negative (n = 21), single vessel 43), double 38), 3 32). Univariate analysis showed that UA, NT-proBNP correlated ACS ( P <...
Mutations in mitochondrial DNA are associated with the pathogenesis of essential hypertension. We report here clinical, genetic, and molecular characterization a three-generation Han Chinese family Most strikingly, this exhibited high penetrance Sequence analysis genome showed presence homoplasmic T5655C mutation tRNAAla, together A4401G adjacent region between tRNAMet tRNAGln. Notably, was localized at acceptor arm disrupted conserved base-pairing (1A-72T), may impair tRNA function....
BACKGROUND To investigate the incidence, risk factors, pathogen distribution, and drug resistance patterns in continuous ambulatory peritoneal dialysis-associated peritonitis (CAPDP). MATERIAL AND METHODS Clinical data for 248 patients who underwent dialysis (CAPD) treatment a single center China from March 2018 to January 2021 were retrospectively collected. The divided into CAPDP group (n=40) non-CAPDP (n=208) according whether occurred. incidence rate, bacterial sensitivity of analyzed....
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by progressive decline in function, leading to disruptions integrity and metabolic resulting lipid deposition excessive accumulation of extracellular matrix (ECM). The pathogenesis NAFLD complex not yet fully understood, contributing the absence specific therapeutic strategies. Peroxisome proliferator-activated receptor gamma (PPARγ) ligand-activated transcription factor pivotal regulating...
Objective: To evaluate the efficacy and safety of low dose sublingual nifedipine dripping pills (5 mg) in treating moderate severe hypertension comparison with normal (10 pills. Methods: This study was designed as a randomized, double-blind, positive drug parallel controlled, multi-center, non-inferiority clinical trial. Patients were enrolled by 14 trial centers, randomly divided into group (sublingual 5 mg pills) control 10 pills). The changes blood pressure monitored continuously within 2...
Abstract Cardiac hypertrophy (CH) is a common risk factor for heart failure and even sudden cardiac death. Molecules have emerged as vital regulators in disorders. LIM domain kinase 1 (Limk1) reported pro‐fibrotic mediator patients with permanent atrial fibrillation it has also been suggested to aggravate dysfunction rats chronic failure. The present study observed that Limk1 was significantly upregulated the vitro model of CH induced by angiotensin II (Ang‐II). Interestingly, silencing led...