A5102877252- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Cardiac Fibrosis and Remodeling
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Galectins and Cancer Biology
- Cardiovascular Function and Risk Factors
- Protein Tyrosine Phosphatases
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Circular RNAs in diseases
- Calcium signaling and nucleotide metabolism
- Heat shock proteins research
- Cell death mechanisms and regulation
- Peroxisome Proliferator-Activated Receptors
- Acute Myocardial Infarction Research
- Redox biology and oxidative stress
- Autophagy in Disease and Therapy
- Lipid metabolism and biosynthesis
- Sirtuins and Resveratrol in Medicine
- Lysosomal Storage Disorders Research
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- FOXO transcription factor regulation
- Cardiac Ischemia and Reperfusion
Huazhong University of Science and Technology
2014-2023
Central Hospital of Wuhan
2012-2023
CCS Associates (United States)
2022
Wuhan University of Science and Technology
2021
Nonalcoholic fatty liver disease (NAFLD), ranging from nonalcoholic to steatohepatitis (NASH), is the leading cause of chronic diseases. Until now, no medications for NAFLD have been approved by relevant governmental agencies. Dual-specificity phosphatase 9 (Dusp9) a member DUSP protein family. Dusp9 expressed in insulin-sensitive tissues, and its expression may be modified with development insulin resistance (IR). However, molecular targets mechanisms action on NASH remain poorly...
Nonalcoholic fatty liver disease (NAFLD), which has a wide global distribution, includes different stages ranging from simple steatosis to nonalcoholic steatohepatitis, advanced fibrosis, and cirrhosis according the degree of severity. Chronic low‐grade inflammation, insulin resistance, lipid accumulation are leading causes NAFLD. To date, no effective medicine for NAFLD been approved by governmental agencies. Our study demonstrated that expression dual‐specificity phosphatase 26 (Dusp26),...
Abstract miRNA‐mediated pyroptosis play crucial effects in the development of myocardial ischaemia/reperfusion (I/R) injury (MIRI). Piperine (PIP) possesses multiple pharmacological especially I/R condition. This study focuses on whether PIP protects MIRI from via miR‐383‐dependent pathway. Rat model was established by 30 minutes LAD ligation and 4 hours reperfusion. Myocardial enzymes, histomorphology, structure function were detected to evaluate MIRI. Recombinant adenoviral vectors for...
Abstract Non-alcoholic steatohepatitis (NASH) has received great attention due to its high incidence. Here, we show that lysosomal-associated protein transmembrane 5 (LAPTM5) is associated with NASH progression through extensive bioinformatical analysis. The level of LAPTM5 bears a negative correlation NAS score. Moreover, degradation mediated ubiquitination modification by the E3 ubquitin ligase NEDD4L. Discovered experiments conducted on male mice, hepatocyte-specific depletion Laptm5...
<h3>Importance</h3> Despite advances in the treatment of ST-segment elevation myocardial infarction (STEMI), little is known about how this evolving knowledge applied current clinical practice China. <h3>Objective</h3> To evaluate hospital performance and temporal trends management STEMI. <h3>Design, Setting, Participants</h3> This study used data from Improving Care for Cardiovascular Disease China–Acute Coronary Syndrome Project, a nationwide quality improvement registry, collaboration...
Myocardial ischemia has become one of the main causes sudden cardiac death worldwide. Autophagy been demonstrated to protect cardiomyocytes from ischemia/reperfusion (I/R)-induced damage. A novel small molecule compound 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid (PT1) previously shown specifically activate 5′-adenosine monophosphate-activated protein kinase (AMPK). Because AMPK activation effectively induces...
Atherosclerosis is a chronic inflammatory disease, and it global clinical problem. The development of new effective therapeutic targets for atherosclerosis necessary. A number microRNAs (miRNAs) have been demonstrated to serve crucial role in atherosclerosis. However, the miRNA (miR)‑217 remains unclear. Therefore, aim present study was investigate mechanism miR‑217 level detected blood patients with using reverse transcription‑quantitative PCR. THP‑1 acute monocytic leukemia cells were...
Background Heart pathological hypertrophy has been recognized as a predisposing risk factor for heart failure and arrhythmia. DUSP (dual‐specificity phosphatase) 26 is member of the family proteins, which significant effect on nonalcoholic fatty liver disease, neuroblastoma, glioma, so on. However, involvement DUSP26 in cardiac remains unclear. Methods Results Our study showed that expression was significantly increased mouse hearts response to pressure overload well angiotensin II–treated...
Background Cardiac hypertrophy has been recognized as an important independent risk factor for the development of heart failure and increases cardiac morbidity mortality. A disintegrin metalloprotease 23 (ADAM23), a member ADAM family, is involved in cancer neuronal differentiation. Although ADAM23 expressed heart, role diseases remains unknown. Methods Results We observed that expression decreased both failing human hearts hypertrophic mice hearts. Cardiac-specific conditional...
The functions of dual-specificity phosphatase 9 (DUSP9) in hepatic steatosis and metabolic disturbance during nonalcoholic fatty liver disease were discussed our prior study. However, its roles the pathophysiology pressure overload-induced cardiac hypertrophy remain to be illustrated. This study attempted uncover potential contributions underpinning mechanisms DUSP9 hypertrophy. Utilizing gain-and-loss-of-functional approaches phenotypes arising from pathological, echocardiographic,...
Abstract Regulatory mechanisms for acute inflammatory responses post myocardial infarction ( MI ) have yet to be fully understood. In particular, the by which cardiac macrophages modulate ‐induced inflammation remains unclear. this study, using a mouse model, we showed that β‐catenin‐mediated signaling was activated in post‐ , especially Ly‐6C‐positive proinflammatory macrophages. Using RAW 264.7‐based β‐catenin reporter cell line, confirmed presence of active and its downstream after ....
Abstract Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are critical processes that involved in atherosclerosis. The aim this study was to explore the role microRNA-491-5p (miR-491-5p) progression atherosclerosis by regulating growth VSMCs. In study, we showed expression miR-491-5p downregulated atherosclerotic plaque tissues plasma samples patients with bioinformatic analysis dual-luciferase reporter assay identified matrix metallopeptidase-9 (MMP-9) a target...
Klotho is a novel anti-aging hormone involved in human coronary artery disease. The present study aimed to detect the effects and mechanism of on cardiomyocytes hypoxia/reoxygenation (H/R) model vitro. Neonatal Sprague-Dawley rat were randomly distributed into experimental groups as follows: Control group; H/R group, 4‑h hypoxia followed by 3‑h reoxygenation; H/R+Klotho incubated with 0.1, 0.2 or 0.4 µg/ml protein for 16 h then subjected hypoxia/3‑h reoxygenation. In order evaluate...
The mechanisms whereby free fatty acids induce endothelial cell apoptosis are not yet understood. present study aimed to investigate the role of PKCδ in acid–induced apoptosis. In addition, we looked for evidence apoptosis‐related interactions between and Fas signal pathway. Human umbilical vein cells were treated with various concentrations transiently transfected siRNA or inhibit expression. Cell proliferation was determined through colorimetric assays, quantified using flow cytometry....
Abstract Non-alcoholic steatohepatitis (NASH) has received great attention due to its extremely high incidence. Our team screened LAPTM5 associated with NASH progression through extensive bioinformatics analysis. We found protein markedly decreased in response lipotoxicity both liver tissues from human and mouse groups, level of was negatively correlated NAS score. Then, we degradation mediated ubiquitination modification by the E3 ubquitin ligase NEDD4L. Hepatocyte specific depleting...