A5004478662- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA modifications and cancer
- Parathyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Nail Diseases and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Mesenchymal stem cell research
- Medical Imaging and Pathology Studies
- Healthcare Systems and Reforms
- PARP inhibition in cancer therapy
- Electrolyte and hormonal disorders
- Circular RNAs in diseases
- Peripheral Neuropathies and Disorders
- Cancer-related Molecular Pathways
- Hospital Admissions and Outcomes
- Moyamoya disease diagnosis and treatment
- Ferroptosis and cancer prognosis
- Mitochondrial Function and Pathology
- Alkaline Phosphatase Research Studies
- Genetic Syndromes and Imprinting
- Cell death mechanisms and regulation
- Epigenetics and DNA Methylation
Second Xiangya Hospital of Central South University
2020-2025
Central South University
2016-2025
First Affiliated Hospital of Xinjiang Medical University
2022
Xinjiang Medical University
2022
Xiangya Hospital Central South University
2016-2020
Arterial calcification is highly prevalent, particularly in patients with end-stage renal disease (ESRD). The osteogenic differentiation of vascular smooth muscle cells (VSMCs) the critical process for development arterial calcification. However, detailed mechanism VSMCs remains to be elucidated. Here, we investigated role exosomes (Exos) derived from endothelial (ECs) and its potential mechanisms ESRD. Accelerated was observed when were exposed ECs culture media stimulated by uremic serum...
Abstract The pathogenesis of vascular calcification in diabetic patients remains elusive. As an effective information transmitter, small extracellular vesicles (sEVs) carry abundant microRNAs (miRNAs) that regulate the physiological and pathological states recipient cells. In present study, significant up-regulation miR-126-5p was observed sEVs isolated from human umbilical vein endothelial cells (HUVECs) stimulated with advanced glycation end-products (A-EC/sEVs). Intriguingly, these...
Objectives: Clinical Trial Simulation (CTS) tools can provide a platform to showcase the results of disease progression models (DPM) and assist in trial design by visualizing exploring trajectories. An automated workflow for CTS tool generation streamline development process, encourage model exploration, promote adherence rigorous software life cycle (SDLC) practices. It also fosters collaboration between scientists developers through modularization. This project's objective is implement...
Objectives: Duchenne Muscular Dystrophy (DMD) is a rare disease with variable and non-linear progressions. To better understand the relationship between longitudinal dynamics clinically meaningful outcome measures, Regulatory Science Consortium (D-RSC) team has developed Bayesian models of progression, dropout joint changes based on velocity endpoints (supine-stand, 4-stair climb, 10-meter/30-foot walk/run), forced vital capacity (FVC) North Star Ambulatory Assessment (NSAA) from DMD...
Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects mass remain unclear. In our present study, we observed that (CT) decreased and quality in mice. Furthermore, a transplant of exosomes derived from plasma mice exposed (CT-EXO) can also impair osteogenic differentiation BMSCs decrease inhibiting autophagic activity. Rapamycin, potent inducer autophagy, reverse or CT-EXO-induced loss. Microarray sequencing...
End-stage renal disease (ESRD) patients usually develop extensive and progressive vascular calcification, lots of calcification inhibitors as well procalcifying factors are involved in the process. However, mechanisms ESRD still ill-defined. In present study, we found that plasma exosomes derived from (ESRD-Ex) promoted smooth muscle cells (VSMCs) significantly, while transplant recipients (RTR-Ex) could partially attenuate VSMCs calcification. Moreover, protein concentration ESRD-Ex was...
Arterial medial calcification is a common disease in patients with type 2 diabetes, end-stage renal and hypertension, resulting high incidence mortality of cardiovascular event. H19 has been demonstrated to be involved diseases like aortic valve diseases. However, role arterial remains largely unknown. We identified that was upregulated ß-glycerophosphate (β-GP) induced vascular smooth muscle cells (VSMCs), cellular model vitro. Overexpression potentiated while knockdown inhibited osteogenic...
To investigate new lncRNAs as molecular markers of T2D.We used microarrays to identify differentially expressed and mRNAs from five patients with T2D paired controls. Through bioinformatics analysis, qRT-PCR validation, ELISA, receiver operating characteristic (ROC) curve analysis 100 controls evaluate the correlation between T2D, whether could be in diagnosis patients.We identified 68 74 mRNAs, respectively. The top upregulated are ENST00000381108.3, ENST00000515544.1, ENST00000539543.1,...
Head and neck squamous cell carcinoma (HNSCC) is a highly prevalent heterogeneous malignancy with dismal overall survival rate. Nevertheless, the effective biomarkers remain ambiguous merit further investigation. Cuproptosis novel defined pathway of programmed death that contributes to progression cancers. Meanwhile, long non-coding RNAs (lncRNAs) play crucial role in biological process tumors. prognostic value cuproptosis-related lncRNAs HNSCC still obscure. This study aimed develop new...
Myasthenia gravis (MG) is an autoantibody-mediated neuromuscular disorder. Approximately 10-20% of all MG patients experience thymoma (benign tumor arising from thymus tissue). Thymectomy has been the standard care for thymomatous myasthenia (TMG). However, clinical outcome TMG after thymectomy not sufficiently studied, especially long-term prognosis. Therefore, aim this study was to analyze characteristics contributing prognostic factors TMG.We reviewed 70 in Xiangya Hospital and classified...
Since the concept of "Day Surgery"; (DS) was firstly put forward in 1995, DS for great saphenous vein varices (GSVV) becomes more and dominant worldwide, but it is accepted only a limited population China. Hence present retrospective study, patients who received regular surgery are compared to assess effectiveness safety GSVV.From 2011 2013, 452 372 inpatient (IS) were collected from hospital main clinical database. Baseline characteristics, prognosis, 12-month-long follow-up compared.Mean...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL Vascular Wall Microenvironment: Endothelial Cells Original Exosomes Mediated Melatonin-Suppressed Calcification and Ageing a M6A Methylation-Dependent Manner KeAi: Bioactive Materials 43 Pages Posted: 23 Feb 2024 Publication Status: Under Review See all articles by Sukang ShanSukang ShanCentral South University - Department of Metabolism...
Abstract Background International experience shows that the suitability of a high-performance healthcare system for its given purposes is reflected in ability to provide continuum services match changing health status population. Although many low- and middle-income countries have sought bring movement away from hospital-centered towards patient-centered healthcare, such efforts often had poor results, one major reasons this inability accurately identify which inpatients need continuing care...
Vascular calcification and vascular ageing are "silent" diseases but highly prevalent in patients with end stage renal failure type 2 diabetes, as well the population. Melatonin (MT) has been shown to induce cardiovascular protection effects. However, role of MT on not well-identified. In this study, aortic transcriptional landscape revealed clues for related cell-to-cell communication between endothelial cells (ECs) smooth muscle (VSMCs) ageing. Furthermore, we elucidated that it was...