Adipose tissue inflammation and reduced pancreatic β-cell function are key issues in the development of cardiovascular disease progressive metabolic dysfunction type 2 diabetes mellitus. The aim this study was to determine effect DPP IV inhibitor sitagliptin on adipose islet a diet-induced obesity model. C57Bl/6J mice were placed high-fat (60% kcal fat) diet for 12 wk, with or without (4 g/kg) as food admix. Sitagliptin significantly fasting blood glucose by 21% well insulin ∼25%. treatment...

Doxorubicin (DOX) is one of the most effective chemotherapeutic drugs. However, its clinical use has been hampered due to development cardiotoxicity. Vitexin, which active ingredient hawthorn leaf extract, various biological activities, including antioxidant and anti-inflammatory actions. The present study aimed investigate whether vitexin was able protect against DOX-induced acute cardiotoxicity in model rats mechanisms this protective effect were assessed. Adult Sprague-Dawley randomly...

Recent years have witnessed increasing research interests of physics-informed neural networks (PINNs) in solving forward, inverse, and parametric problems governed by partial differential equations (PDEs). Despite their promise, PINNs still face significant challenges many scenarios due to ill-conditioning. Time-stepping-oriented network (TSONN) addresses this reformulating the ill-conditioned optimization problem into a series well-conditioned sub-problems, greatly improving its ability...

This paper addresses the task of learning an agent model behaving like humans, which can jointly perceive, predict, and act in egocentric worlds. Previous methods usually train separate models for these three abilities, leading to information silos among them, prevents abilities from each other collaborating effectively. In this paper, we propose a joint predictive model, named EgoAgent, that simultaneously learns represent world, predict future states, take reasonable actions with single...

Among malignant tumors, hepatocellular carcinoma (HCC) is both prevalent and highly lethal. Most patients with advanced-stage liver cancer have a poor prognosis. Death-associated protein 3 (DAP3) reportedly related to tumors may hold great promise for the future. DAP3 transcriptome data along clinical information were obtained from The Cancer Genome Atlas (TCGA), GEO, ICGC databases. We assessed its prognostic value, relevance, associated pathways, immune infiltration, gene mutations,...

BACKGROUND We investigated the association between 8 single-nucleotide polymorphisms (SNPs) at 3 genetic loci (CDKAL1, CDKN2A/2B and FTO) with type 2 diabetes (T2D) in a Uyghur population. MATERIAL AND METHODS A case-control study of 879 patients T2D 895 non-diabetic controls was conducted Hospital Xinjiang Medical University 2010 2013. Eight SNPs CDKAL1, FTO were analyzed using Sequenom MassARRAY®SNP genotyping. Factors associated assessed by logistic regression analyses. Gene-gene...

Background Diabetes is a major global public health problem driven by high prevalence of metabolic risk factors. Objective To describe the differences factors type 2 diabetes, as well glycemic control and complicated diabetic complications between rural urban Uygur residents in Xinjiang Autonomous Region China. Methods This comparative cross-sectional study, conducted among 2879 918 participants Xinjiang, China, assessed diabetes related settlements. Results Compared to areas, had higher...

Although both preclinical and clinical studies have shown the great application potential of MSCs (mesenchymal stem/stromal cells) in treating many kinds diseases, therapeutic inconsistency resulting from cell heterogeneity is major stumbling block to their applications. Cell population diversity batch variation expansion medium are two inducers MSC heterogeneity. was investigated through single-cell RNA sequencing analysis human derived umbilical cord expanded with fully chemically defined...

Certain long non-coding RNAs (lncRNAs) have potential peptide-coding abilities. Here, the role and molecular basis of RNF217-AS1-encoded peptide in stomach cancer (SC) tumorigenesis were explored. lncRNAs associated with SC pathogenesis macrophage infiltration searched by bioinformatics analysis. The gene mRNA protein levels examined RT-qPCR western blot assays, respectively. Cell viability, migratory, invasive abilities measured CCK-8, Transwell migration, invasion biological processes...

Background: Genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene have been reported to be strongly associated with type diabetes mellitus (T2DM) in Icelandic, Danish and American populations further replicated other European populations, African Americans, Mexican Asian populations. The aim present study was investigate association TCF7L2 T2DM a Uygur population China. Methods: 877 patients 871 controls were selected for study. Two single nucleotide (SNPs) (rs12255372...

Abstract Background Previously, we have demonstrated that the batch variations of human platelet lysate (conventional MSC expansion medium) induce heterogeneity and therapeutic inconsistency. On other hand, MSCs expanded with chemical defined medium improved consistency. Methods In current study, studied subpopulation composition variation in different types batches scRNA-seq analysis. Results media higher levels from perspective cell at transcriptome The CD317 + has enhanced immune...

Plants lack behavioral responses to avoid dramatic environmental changes associated with the annual seasons. For survival, they have evolved complex sensory systems sense fluctuations in light and optimize their architecture response these cues. Phytochrome A (phyA) was initially identified as a photoreceptor that senses far-red signals. It then playing central role promoting hypocotyl growth, fiber development, flowering time variety of plants including Arabidopsis, rice, soybean cotton....

Major depressive disorder (MDD) with diabetes mellitus (DM) significantly reduces the quality of patient's life, and currently, there is no effective treatment. This study explored feasibility Glucagon-like peptide-1 (GLP-1) in treating MDD combined DM. The protective effects GLP-1 on mouse hippocampal neuronal cell line HT22 cultured corticosterone (CORT) high glucose (HG) were assessed. cells CORT + HG to construct a model Cell viability apoptosis/necrocytosis detected by CCK-8 assay flow...

Background: Sepsis is a complex, life-threatening clinical syndrome that can cause other related diseases, such as acute kidney injury (AKI). Circular RNA (circRNA) type of non-coding with diverse range functions, and it plays essential roles in miRNA sponge. CircRNA huge part the development various diseases. competing endogenous (ceRNA) regulatory network are unknown factors onset progression septic AKI (SAKI). This study aimed to clarify complex circRNA-associated mechanism circRNAs SAKI....

To investigate new lncRNAs as molecular markers of T2D.We used microarrays to identify differentially expressed and mRNAs from five patients with T2D paired controls. Through bioinformatics analysis, qRT-PCR validation, ELISA, receiver operating characteristic (ROC) curve analysis 100 controls evaluate the correlation between T2D, whether could be in diagnosis patients.We identified 68 74 mRNAs, respectively. The top upregulated are ENST00000381108.3, ENST00000515544.1, ENST00000539543.1,...

Abstract Background Type 2 diabetes (T2DM) susceptibility varies among different populations and is affected by gene single nucleotide polymorphism (SNP). Insulin-like growth factor ( IGF )-1 gene, which has many SNP loci, involved in T2DM pathogenesis. However, the relationship of IGF-1 with Uyghur population less studied. Objective To investigate between Xinjiang, China. Methods This study enrolled 220 cases (122 males (55.46%) 98 females (44.54%); mean age 53.40 ± 10.94 years) patients...

To investigate the association between KCNQ1 gene polymorphisms and type 2 diabetes (T2D) in an admixed ethnic minority, Uyghur population, living Northwest region of China.We genotyped three tagging single-nucleotide rs2283171, rs11023485, rs2283208 1006 T2D participants 1004 controls conducted analysis.The frequencies AG GG genotypes G allele rs2283171 were higher control group (51.4%, 22%, 47.7%, respectively) than case (49%, 17.6%, 42.1%, respectively). The minor decreased risk with a...

To assess the association of glucokinase regulator protein (GCKR) gene polymorphisms and type 2 diabetes (T2D) among ethnic Uygurs from Xinjiang, China.One thousand six T2D patients 1004 healthy controls were recruited. The rs780094 genotype GCKR was determined with a Sequenom Mass ARRAY system.The distribution AA, AG GG genotypes not statistically different between two groups (P>0.05). After adjusting confounding factors, an observed in additive dominant model (OR=1.181, 95%CI: 1.021-1.366,...