A5012550408- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Adipose Tissue and Metabolism
- Pluripotent Stem Cells Research
- Growth Hormone and Insulin-like Growth Factors
- Lipid metabolism and disorders
- IL-33, ST2, and ILC Pathways
- Metabolism, Diabetes, and Cancer
- 3D Printing in Biomedical Research
- Diabetes Management and Research
- FOXO transcription factor regulation
- Eosinophilic Esophagitis
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Liver Disease Diagnosis and Treatment
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Transgenic Plants and Applications
- Cytomegalovirus and herpesvirus research
- Tendon Structure and Treatment
- Genetic diversity and population structure
- Musculoskeletal pain and rehabilitation
Third Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Allegheny Health Network
2014-2024
Carnegie Mellon University
2016-2024
Allegheny-Singer Research Institute
2016-2023
Drexel University
2023
People's Hospital of Xinjiang Uygur Autonomous Region
2022
Qingdao Mental Health Center
2017
University of Pittsburgh
2003-2016
Atlantic General Hospital
2016
Growth hormone (GH) plays a pivotal role in growth and metabolism, with promotion mostly attributed to generation of insulin-like factor I (IGF-I) liver or at local sites GH action, whereas the metabolic effects are considered be intrinsic itself. To distinguish from those IGF-I, we developed Cre-lox-mediated model tissue-specific deletion receptor (GHR). Near total GHR (GHRLD) had no effect on body bone linear despite >90% suppression circulating IGF-I; however, density was significantly...
Skeletal muscle development, nutrient uptake, and utilization is largely coordinated by growth hormone (GH) its downstream effectors, in particular, IGF-1. However, it not clear which effects of GH on skeletal are direct secondary to GH-induced IGF-1 expression. Thus, we generated mice lacking either receptor (GHR) or (IGF-1R) specifically muscle. Both exhibited impaired development characterized reductions myofiber number area as well accompanying deficiencies functional performance....
Excessive endogenous glucose production contributes to fasting hyperglycemia in diabetes. This effect stems from inept insulin suppression of hepatic gluconeogenesis. To understand the underlying mechanisms, we studied ability forkhead box O6 (FoxO6) mediate action on gluconeogenesis and its contribution metabolism.We characterized FoxO6 metabolism cultured hepatocytes rodent models dietary obesity, resistance, or insulin-deficient We determined genetically modified mice with gain- versus...
One of the major obstacles in organ transplantation is to establish immune tolerance allografts. Although immunosuppressive drugs can prevent graft rejection a certain degree, their efficacies are limited, transient, and associated with severe side effects. Induction thymic central allografts remains challenging, largely because difficulty maintaining donor epithelial cells vitro allow successful bioengineering. Here, authors show that three-dimensional scaffolds generated from...
FoxO1 plays an important role in mediating the effect of insulin on hepatic metabolism. Increased activity is associated with reduced ability to regulate glucose production. However, underlying mechanism and physiology remain unknown. We studied metabolism normal vs. insulin-resistant liver under fed fasting conditions. gain function, as a result adenovirus-mediated or transgenic expression, augmented gluconeogenesis, accompanied by decreased glycogen content increased fat deposition liver....
Apolipoproteins (apo) are constituents of lipoproteins crucial for lipid homeostasis. Aberrant expression apolipoproteins is associated with metabolic abnormalities. Here we characterized apolipoprotein D (apoD) in triglyceride metabolism. Unlike canonical that mainly produced the liver, apoD an atypical broad tissue distribution. We show circulating present HDL and, to a lesser extent, LDL and VLDL its plasma levels were reduced db/db mice visceral obesity altered Elevated production,...
The GH receptor (GHR) is expressed on macrophages. However, the precise role of in regulation macrophage function unclear. We hypothesized that soluble factors including cytokines produced by macrophages a GH-dependent manner regulate adipogenesis. confirmed expression and functional integrity GHR J774A.1 cells. Conditioned medium (CM) from inhibited adipogenesis 3T3-L1 assay. CM GH-treated decreased inhibitory effect This preadipocyte differentiation was active only during first (early)...
We investigated GH action on macrophage (MΦ) by creating a MΦ-specific receptor-null mouse model (MacGHR KO). On normal diet (10% fat), MacGHR KO and littermate controls exhibited similar growth profiles glucose excursions intraperitoneal (ipGTT) insulin tolerance (ITT) tests. However, when challenged with high fat (HFD, 45% fat) for 18 weeks, mice impaired ipGTT ITT compared controls. In KO, adipose-tissue (AT) MΦ abundance was increased skewing toward M1 polarization. Expression of...
Non-alcoholic fatty liver disease (NAFLD) is one of the most common forms chronic diseases closely associated with obesity and insulin resistance; deficient growth hormone (GH) action in has been implicated as a mechanism. Here, we investigated evolution NAFLD aged mice liver-specific GHR deletion.We examined glucose tolerance, responsiveness, lipid profiles male (44-50 weeks) GHRLD. We performed proteomics analysis, pathway-based Superarray assay, well quantitative RT-PCR to gain molecular...
An experimental laboratory study.To investigate the pathogenesis of intervertebral disc degeneration (IDD) in a murine model type 1 diabetes mellitus (DM), namely nonobese diabetic (NOD) mouse.IDD is leading contributor low back pain, which represents one most disabling symptoms within adult population. DM chronic metabolic disease currently affecting 10 adults United States. It associated with an increased risk developing IDD, but underlying process remains poorly understood.Total...
Excessive production of triglyceride-rich very low-density lipoproteins (VLDL-TG) contributes to hypertriglyceridemia in obesity and type 2 diabetes. To understand the underlying mechanism, we studied hepatic regulation VLDL-TG by (forkhead box O6) FoxO6, a forkhead transcription factor that integrates insulin signaling metabolism. We showed transgenic mice expressing constitutively active FoxO6 allele developed hypertriglyceridemia, culminating elevated levels impaired postprandial TG...
BACKGROUND We investigated the association between 8 single-nucleotide polymorphisms (SNPs) at 3 genetic loci (CDKAL1, CDKN2A/2B and FTO) with type 2 diabetes (T2D) in a Uyghur population. MATERIAL AND METHODS A case-control study of 879 patients T2D 895 non-diabetic controls was conducted Hospital Xinjiang Medical University 2010 2013. Eight SNPs CDKAL1, FTO were analyzed using Sequenom MassARRAY®SNP genotyping. Factors associated assessed by logistic regression analyses. Gene-gene...
Anopheles sinensis is a competent malaria vector in China. An understanding of population structure important to the vector-based control programs. However, there no adequate data A. genetics available yet.
Inducible co-stimulator ligand (ICOSL) is a rather newly defined co-stimulatory molecule, which, through interaction with ICOS expressed on T cells, plays an important role in T-cell activation, differentiation and function. Th2-type immune responses are critical for the development maintenance of allergic including asthma. Using knockout (KO) mice, we have assessed ICOSL airway inflammation responsiveness using standard mouse asthma model induced by ovalbumin (OVA) sensitization challenge....