A5017864664- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- COVID-19 Impact on Reproduction
- Pregnancy and Medication Impact
- CRISPR and Genetic Engineering
- Diet and metabolism studies
- Pregnancy-related medical research
- Neonatal Respiratory Health Research
- Pluripotent Stem Cells Research
- Neuroscience of respiration and sleep
- Whipple's Disease and Interleukins
- Congenital Diaphragmatic Hernia Studies
- Gut microbiota and health
- Immunodeficiency and Autoimmune Disorders
- 3D Printing in Biomedical Research
- Gastrointestinal motility and disorders
- Diabetes and associated disorders
- Preterm Birth and Chorioamnionitis
Cornell University
2022-2024
Wayne State University
2016-2024
Weill Cornell Medicine
2023
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2018
National Institutes of Health
2018
Mouse Embryonic Stem Cells (mESCs) are unique in their self-renewal and pluripotency. Hypothetically, mESCs model gestational stress effects or stresses of vitro fertilization/assisted reproductive technologies drug/environmental exposures that endanger embryos. Testing responses should diminish expedite vivo embryo screening. Transgenic for green fluorescent protein (GFP) reporters differentiation use the promoter platelet-derived growth factor receptor (Pdgfr)a driving GFP expression to...
SUMMARY In response to antigens, B cells undergo affinity maturation and class switching mediated by activation-induced cytidine deaminase (AID) in germinal centers (GCs) of secondary lymphoid organs, but uncontrolled AID activity can precipitate autoimmunity cancer. The regulation GC antibody diversification is fundamental importance not well understood. We found that autoimmune regulator (AIRE), the molecule essential for T cell tolerance, expressed a CD40-dependent manner, interacts with...
Abstract Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell responses, but mechanisms controlling these distinct outcomes remain poorly understood and accumulating evidence indicates that aberrant immunity to intestinal microbiota is causally associated with infectious, inflammatory, malignant diseases 1–8 . Here, we define a critical pathway fate versus cells are specific for express transcription factor RORγt. We profiled all RORγt + immune at...
Abstract Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell responses, but mechanisms controlling these distinct outcomes remain poorly understood, and accumulating evidence indicates that aberrant immunity to intestinal microbiota is causally associated with infectious, malignant diseases. Here we define a critical pathway fate versus cells respond express transcription factor RORγt. We profiled all RORγt +immune at single-cell resolution from...