A5019121475- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Microscopic Colitis
- Immune Cell Function and Interaction
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal and GI Pathology
- Intestinal Malrotation and Obstruction Disorders
- Diverticular Disease and Complications
- Pharmaceutical studies and practices
- Immunodeficiency and Autoimmune Disorders
- Venous Thromboembolism Diagnosis and Management
- Healthcare cost, quality, practices
- Foreign Body Medical Cases
- Celiac Disease Research and Management
- Adolescent and Pediatric Healthcare
- Appendicitis Diagnosis and Management
- Pediatric health and respiratory diseases
- Cerebral Venous Sinus Thrombosis
- Lymphatic Disorders and Treatments
- Gut microbiota and health
- Autoimmune and Inflammatory Disorders
- Enhanced Recovery After Surgery
Cornell University
2016-2025
University Gastroenterology
2025
Presbyterian Hospital
2006-2023
Weill Cornell Medicine
2017-2023
New York Hospital Queens
2007-2015
NewYork–Presbyterian Hospital
2007-2015
Albert Einstein College of Medicine
1991-1996
Montefiore Medical Center
1996
Winthrop-University Hospital
1996
Conway School of Landscape Design
1991
Ironing out the details of mucosal healing Anemia is a frequent complication disorders such as inflammatory bowel disease, occurring in part result increased bleeding into intestine. Bessman et al. show that peptide hormone hepcidin, which regulates systemic iron homeostasis, required for intestinal repair mouse model disease (see Perspective by Rescigno). This effect was independent hepatocyte-produced hepcidin and levels. Instead, production conventional dendritic cells necessary...
Innate lymphoid cells (ILCs) can promote host defense, chronic inflammation, or tissue protection and are regulated by cytokines neuropeptides. However, their regulation diet microbiota-derived signals remains unclear. We show that an inulin fiber promotes Tph1-expressing inflammatory ILC2s (ILC2INFLAM) in the colon, which produce IL-5 but not tissue-protective amphiregulin (AREG), resulting accumulation of eosinophils. This exacerbates inflammation a murine model intestinal damage ILC2-...
Abstract Background A seroproteomic index (i.e. the serum index) corresponds to 13 protein markers, including CRP, combined as a multianalyte assay with score range 0-100 where higher is associated probability of endoscopic activity in adult CD. We aimed evaluate its performances pediatric Methods Children CD were enrolled from two separate cohorts. Cohort 1 multiple centers United States (n=118) and cohort 2, was multinational (n=160). simple for (SESCD) collected (<3 points indicate...
ABSTRACT Objective: Given the social constraints imposed by a gluten‐free diet, it can be hypothesized that children with celiac disease (CD) living in United States have reduced health‐related quality of life (HRQOL); however, there is no validated CD‐specific HRQOL instrument for States. The goals this study were to develop and validate 8 18 years age CD report these using both generic‐ disease‐specific instruments. Methods: This was prospective focus group methodology then administered...
Cerebral venous thrombosis (CVT) is a rare but devastating complication of inflammatory bowel disease (IBD). Here we describe six IBD patients with cerebral thrombosis. The presented hours to days headache and were found have on imaging. Four the had ulcerative colitis two Crohn's disease. All treated therapeutic anticoagulation. There deaths; one patient became comatose died despite anticoagulation while other recovered well from sinus after perforation 3 weeks later. This case series...
The risk of venous thromboembolism (VTE) is significantly increased in patients with inflammatory bowel disease (IBD). For the adult population, prophylaxis guidelines exist to help guide physicians their management high-risk IBD patients. Although it known that children also experience rates VTE, there no clear consensus on how best prevent these unwanted complications. We sought better understand practicing pediatric gastroenterologists' awareness this issue and practices surrounding...
Abstract Background Most Crohn’s disease [CD] patients require surgery. Ileitis recurs after most ileocolectomies and is a critical determinant for outcomes. The impacts of ileocolectomy-induced bile acid [BA] perturbations on intestinal microbiota inflammation are unknown. We characterized the relationships between ileocolectomy, stool BAs, in inflammatory bowel [IBD]. Methods Validated IBD clinical endoscopic assessments were prospectively collected. Stool primary secondary BA...
The primary aim of this Clinical Report by the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition is to provide formal guidance pediatric gastroenterologists clinicians, health systems, insurance payers regarding home- office-based infusions biologic therapies in inflammatory bowel disease. Patients America are increasingly denied coverage based on "place service" codes at hospital-based infusion units where treating clinicians primarily care. A task force with...
Objectives. The available literature on pulmonary disease in pediatric inflammatory bowel is limited. We evaluated the prevalence of manifestations and their association with severity. Methods. Patients completed St. George’s Respiratory Questionnaire (SGRQ), a self-reported measure quality life patients disease. Chart review provided demographic information Pediatric Crohn’s Disease Activity Index (PCDAI) Ulcerative Colitis scores. Regression models were utilized to evaluate associations...
Abstract Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell responses, but mechanisms controlling these distinct outcomes remain poorly understood and accumulating evidence indicates that aberrant immunity to intestinal microbiota is causally associated with infectious, inflammatory, malignant diseases 1–8 . Here, we define a critical pathway fate versus cells are specific for express transcription factor RORγt. We profiled all RORγt + immune at...
Background: Delays in biologic or small molecule medication administration are associated with increased adverse events, hospitalization, and surgery inflammatory bowel disease (IBD). We evaluated the impact of a quality improvement (QI) intervention on time to biologics molecules (TABS) IBD. Methods: Data were retrospectively extracted for IBD patients prescribed from convenience sample providers participating an accredited QI educational (baseline cohort). Subsequent intervention, data...