A5024900540- Genetics, Aging, and Longevity in Model Organisms
- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- Sirtuins and Resveratrol in Medicine
- RNA Interference and Gene Delivery
- Adipose Tissue and Metabolism
- Drug Transport and Resistance Mechanisms
- Mitochondrial Function and Pathology
- Circadian rhythm and melatonin
- Protein Structure and Dynamics
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Microbial Metabolic Engineering and Bioproduction
- Gut microbiota and health
- Enzyme Structure and Function
- Ginger and Zingiberaceae research
- Advanced biosensing and bioanalysis techniques
- GABA and Rice Research
Cornell University
2020-2025
Ithaca College
2021
Nanjing University
2019
State Key Laboratory of Analytical Chemistry for Life Science
2019
Protein lipidation plays critical roles in regulating protein function and localization. However, the chemical diversity specificity of fatty acyl group utilization have not been investigated using untargeted approaches, it is unclear to what extent structures biosynthetic origins S -acyl moieties differ from N - O -fatty acylation. Here, we show that acylation patterns Caenorhabditis elegans markedly between different amino acid residues. Hydroxylamine capture revealed predominant cysteine...
Here, we report a new strategy for the construction of peptide nucleic acid-microRNA nanocomplex with dual function to simultaneously suppress oncogenic microRNAs and upregulate tumor-suppressive in target cancer cells.
Reactive electrophilic intermediates such as coenzyme A esters play central roles in metabolism but are difficult to detect with conventional strategies. Here, we introduce hydroxylamine-based stable isotope labeling convert reactive into derivatives that easily detectable via LC–MS. In the model system Caenorhabditis elegans, parallel treatment 14NH2OH and 15NH2OH revealed >1000 labeled metabolites, e.g., derived from peptide, fatty acid, ascaroside pheromone biosyntheses. Results NH2OH of...