Sanchita Kashyap
A5021621708- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Sulfur Compounds in Biology
- Autophagy in Disease and Therapy
- Redox biology and oxidative stress
- Ginger and Zingiberaceae research
- Sirtuins and Resveratrol in Medicine
- Drug Transport and Resistance Mechanisms
- Gut microbiota and health
- Pediatric health and respiratory diseases
- Cardiovascular Function and Risk Factors
Cornell University
2022-2025
Rutgers New Jersey Medical School
2021-2022
Rutgers, The State University of New Jersey
2021-2022
Innate lymphoid cells (ILCs) can promote host defense, chronic inflammation, or tissue protection and are regulated by cytokines neuropeptides. However, their regulation diet microbiota-derived signals remains unclear. We show that an inulin fiber promotes Tph1-expressing inflammatory ILC2s (ILC2INFLAM) in the colon, which produce IL-5 but not tissue-protective amphiregulin (AREG), resulting accumulation of eosinophils. This exacerbates inflammation a murine model intestinal damage ILC2-...
[Figure: see text].
PERM1 is a striated muscle-specific regulator of mitochondrial bioenergetics. We previously demonstrated that downregulated in the failing heart and positively regulates metabolic genes known as targets transcription factor ERRα its coactivator PGC-1α cultured cardiomyocytes. The aims this study were to determine effect loss on cardiac function energetics using newly generated Perm1-knockout (Perm1-/-) mice investigate molecular mechanisms transcriptional control.Echocardiography showed...
Modification of cysteine residues by oxidative and nitrosative stress affects structure function proteins, thereby contributing to the pathogenesis cardiovascular disease. Although major thioredoxin 1 (Trx1) is reduce disulfide bonds, it can also act as either a denitrosylase or transnitrosylase in context-dependent manner. Here we show that Trx1 transnitrosylates Atg7, an E1-like enzyme, stimulating autophagy. During ischemia, was oxidized at Cys32-Cys35 oxidoreductase catalytic center...