A5015076381- Inflammatory Bowel Disease
- Microscopic Colitis
- Pharmaceutical studies and practices
- Adolescent and Pediatric Healthcare
- Eosinophilic Esophagitis
- Liver Diseases and Immunity
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Childhood Cancer Survivors' Quality of Life
- Celiac Disease Research and Management
- Acute Lymphoblastic Leukemia research
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Hepatitis B Virus Studies
- Biosimilars and Bioanalytical Methods
- Colorectal Cancer Screening and Detection
- Hepatitis Viruses Studies and Epidemiology
- Pregnancy and Medication Impact
- Viral gastroenteritis research and epidemiology
- Neurological and metabolic disorders
- Intestinal Malrotation and Obstruction Disorders
- Child Nutrition and Feeding Issues
- Infant Nutrition and Health
- Complement system in diseases
- Soft tissue tumor case studies
Stanford University
2024-2025
Stanford Medicine
2024-2025
Rainbow Babies & Children's Hospital
2016-2024
Case Western Reserve University
2020-2023
GTx (United States)
2019
Cleveland Clinic
2010-2014
Nationwide Children's Hospital
2010
Australian Red Cross Lifeblood
2004
Nonalcoholic fatty liver disease (NAFLD) is one of the most common complications childhood obesity. Our objective was to investigate association breath volatile organic compounds with diagnosis NAFLD in children.Patients were screened an ultrasound abdomen evaluate for NAFLD. Exhaled collected and analyzed per protocol using selective ion flow tube mass spectrometry (SIFT-MS).Sixty patients included study (37 23 normal liver). All children overweight or obese. The mean age 14.1±2.8 years 50%...
Hepatitis B virus (HBV) reactivation has been described in patients treated with infliximab for inflammatory bowel disease (IBD). This resulted a "black box" warning. Although universal vaccination against hepatitis was implemented the United States 1991, up to 10% of vaccine recipients fail respond adequate anti-hepatitis surface antibodies (anti-HBs) levels after primary series vaccinations. In addition, anti-HBs are expected decline time. The objectives this study were determine HBV...
Abstract Objectives Early biologic initiation, dose optimization, and therapy modification based on disease phenotype are key to improving outcomes in pediatric inflammatory bowel (IBD). Enacting optimized is often impeded by the lack of United States Food Drug Administration (FDA) approval for use newer advanced therapies or intensified dosing regimens. These barriers result initial payor denial coverage added prior authorization burden physicians, leading patient delays medication...
Background/Objectives: In adolescent patients with ulcerative colitis refractory to anti-tumor necrosis factor (TNF) therapy, episodes of acute severe (ASUC) require hospitalization or surgery. Upadacitinib can be a potential colectomy-sparing agent in adult ASUC receiving intensified dosing. Methods: This case series evaluates clinical outcomes rescue upadacitinib dosing ASUC. We included adolescents admitted anti-TNF treated 30 mg twice daily upadacitinib. The primary outcome was the...
INTRODUCTION: Obesity is common among patients with pediatric Crohn's disease (PCD). Some adult studies suggest obese respond less well to anti-tumor necrosis factor (TNF) treatment. This study sought compares anti-TNF response and levels between normal high body mass index (BMI). METHODS: The COMBINE trial compared monotherapy combination therapy methotrexate in PCD. In this secondary analysis, a comparison of time-to-treatment failure BMI vs Z -score >1, adjusting for prescribed...
Thiopurines are a common, effective means of maintaining remission in pediatric Crohn disease (CD). Methotrexate (MTX) may be considered for those intolerant or unresponsive to thiopurines. The purpose this study was examine the effectiveness MTX as maintenance therapy patients previously treated with thiopurines.All at Nationwide Children's Hospital from 1998 2007 an International Classification Diseases code indicative CD were identified. Patients diagnosis CD, history prior thiopurine...
Abstract Background Cessation of statural growth occurs with radiographic closure the plates, radiographically defined as bone age (BA) 15 years in females and 17 males. Methods We determined frequency continued compared total height gain beyond time expected plate chronological at achievement final adult Crohn’s disease (CD) vs ulcerative colitis (UC) described velocity curves inflammatory bowel (IBD) children National Health Nutrition Examination Survey (NHANES). identified all older than...
Biosimilars are biological agents that have been demonstrated to similar safety and efficacy profiles as the originator. The objective of this study was evaluate perspectives pediatric gastroenterologists in United States (U.S.) toward biosimilar use explore factors impact their comfort level with prescribing infliximab biosimilars.
Acute rejection is a leading cause of early renal-allograft failure. The human Fc gamma receptor IIA (FcgammaRIIA) forms an essential link between the humoral branch and effector cells immune system. In this study, we examined FcgammaRIIA genotypes in recipients (rejectors) with acute graft number control groups to investigate possible association polymorphism rejection. distribution study patient group differed from groups. frequency homozygosity for FcagammaRIIA-R/R131 rejectors was...
Endoscopic mucosal improvement is the gold standard for assessing treatment efficacy in clinical trials of Crohn's disease. Current endoscopic indices are not routinely used practice. The lack information large registries limits their use research. A quick, easy, and accurate method needed clinicians real-world We developed tested a novel simplified assessment disease (SEMA-CD).We 5-point scale ranking severity ileum colon based on Simple Score (SES-CD). Central readers were trained to...
Abstract Objectives Systemic steroids can be used for induction of inflammatory bowel disease (IBD), but are not recommended as long‐term therapy. Steroid weaning requires rigorous monitoring symptoms, which may cumbersome and lead to missed opportunities. We aim describe our local quality improvement (QI) initiative improve standardize the steroid process. Methods After identifying drivers weaning, a protocol was developed implemented newly diagnosed IBD patients started on subsequently...
Significance: Eosinophilic esophagitis (EoE) is an inflammatory condition characterized by T helper-2 (T H 2) cytokines. Ulcerative colitis (UC) and Crohn disease (CD) are conditions with different clinical presentations immune profiles. UC associated 2 cytokines CD 1 We investigated potential differences in the association of EoE because these Methods: utilized ICD-9 ICD-10 codes to find patients bowel (IBD) EoE. defined as any esophageal biopsy >15 eosinophils. collected demographic,...
The primary aim of this Clinical Report by the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition is to provide formal guidance pediatric gastroenterologists clinicians, health systems, insurance payers regarding home- office-based infusions biologic therapies in inflammatory bowel disease. Patients America are increasingly denied coverage based on "place service" codes at hospital-based infusion units where treating clinicians primarily care. A task force with...
Loss of response in pediatric inflammatory bowel disease patients treated with biologic medications can be due to development anti-drug antibodies. Natural history antibodies has not been well described disease. The primary aim this study was describe a single-center experience for the temporal onset detection.We performed retrospective, chart review at Division Pediatric Gastroenterology, Hepatology, and Nutrition Rainbow Babies Children's Hospital from 2010 2015. Patients were infliximab...
Fecal calprotectin (FC) is a noninvasive marker of intestinal inflammation used for screening and ongoing monitoring inflammatory bowel disease (IBD); it unclear the association specific FC values with activity. The aim our study was to examine endoscopic histologic severity.We performed retrospective chart review patients who had done between 30 days 1 day before colonoscopy at institution. IBD were graded using simple score Crohn's or Mayo ulcerative colitis. Histologic slides Geboes...
To reduce lapses in care for pediatric inflammatory bowel disease (IBD) patients approaching adulthood, a health maintenance transition visit (HMV) was developed to supplement standard medical (SMV). Our aim assess the effect of HMV on readiness. A retrospective chart review conducted at single center with demographics and clinical data from SMV visits. Effectiveness assessed by patient questionanaire-9 (PHQ-9) readiness assessment questionnaire (TRAQ) scores. total 140 patients, 80%...
Abstract Background Endoscopic mucosal healing is the gold standard for evaluating Crohn’s disease (CD) treatment efficacy. Standard endoscopic indices are not routinely used in clinical practice, limiting quality of retrospective research. A method retrospectively quantifying activity from documentation needed. We evaluated simplified assessment CD (SEMA-CD) to determine if it can accurately quantify severity recorded colonoscopy reports. Methods Pediatric patients with underwent that was...