A5027263072- Inflammatory Bowel Disease
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders Research
- Gastrointestinal motility and disorders
- Gastrointestinal disorders and treatments
- Intestinal Malrotation and Obstruction Disorders
- Pharmaceutical studies and practices
- Pancreatitis Pathology and Treatment
- Mycobacterium research and diagnosis
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Diseases and Immunity
- Pediatric Pain Management Techniques
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- Eosinophilic Esophagitis
- Congenital Diaphragmatic Hernia Studies
- Autoimmune and Inflammatory Disorders
- Regulation of Appetite and Obesity
- Biomedical Research and Pathophysiology
- Intestinal and Peritoneal Adhesions
- Blood disorders and treatments
- Health and Well-being Studies
- Surgical Sutures and Adhesives
- Dermatologic Treatments and Research
- Prostate Cancer Treatment and Research
SUNY Upstate Medical University
2012-2024
Golisano Children's Hospital
2012-2024
Mount Sinai Hospital
2018
Hartford Financial Services (United States)
2017
Alfred I. duPont Hospital for Children
2008-2016
National Institute of General Medical Sciences
2016
National Institutes of Health
2016
In-Q-Tel
2016
Thomas Jefferson University
2010-2016
Dupont Hospital
2013
Prostate cancer is one of the most common cancers in men. Incidence rates increase with age and are substantially higher black men than white This study examines variations use radical prostatectomy radiation by geographic area, age, race.Data from National Cancer Institute's Surveillance, Epidemiology, End-Results Program (SEER) were used to examine treatment differences. Current treatments generally consist prostatectomy, radiation, or careful observation for clinically localized regional...
The fecal pancreatic elastase-1 (FE-1) test is considered a simple, noninvasive, indirect measure of function. We aimed to evaluate the performance FE-1 compared with direct function (PFT) secretin stimulation in children.Data 70 children (6 months-17 years age) who had both and PFT were analyzed.The average concentration was 403 ± 142 μg/g. Eleven concentrations below 200 μg/g, 23 between 201 500 36 above elastase activity measured on 49.1 38.6 μmol · min (-1)· ml(-1) 11 established cutoff...
INTRODUCTION: Obesity is common among patients with pediatric Crohn's disease (PCD). Some adult studies suggest obese respond less well to anti-tumor necrosis factor (TNF) treatment. This study sought compares anti-TNF response and levels between normal high body mass index (BMI). METHODS: The COMBINE trial compared monotherapy combination therapy methotrexate in PCD. In this secondary analysis, a comparison of time-to-treatment failure BMI vs Z -score >1, adjusting for prescribed...
Ghrelin and obestatin are 2 gastric hormones with opposite effects on food intake body weight. We investigated plasma ghrelin in children failure to thrive (FTT) obesity as compared age-matched controls.A total of 63 were included the study: 13 FTT, 17 obesity, 33 controls. Children fasted for at least 8 hours before specimen collection. Both measured using commercially available enzyme immunoassay kits.Ghrelin levels FTT not significantly different from that controls (P >0.05). In lower =...
In contrast to pediatric Crohn's disease (CD), little is known in ulcerative colitis (UC) about the relationship between phenotype and serologic reactivity microbial other antigens. The aim of this study was examine serology a well-characterized inception cohort children newly diagnosed with UC during PROTECT Study (Predicting Response Standardized Pediatric Colitis Therapy). Patients were recruited from 29 participating centers. Demographic, clinical, laboratory, (pANCA, ASCA IgA/IgG,...
Objective: To examine the role of provider communication about psychosocial causes abdominal pain and recommendations for intervention during a gastroenterology clinic visit in predicting families' causal beliefs perceptions treatment acceptability. Method: Participants were 57 children with diagnosed or suspected pain-related functional gastrointestinal disorder (FGID) presenting an outpatient follow-up their accompanying parent. Children parents completed questionnaires assessing child...
Primrose syndrome (OMIM 606025), caused by heterozygous pathogenic variants in the ZBTB20 gene 606025) is characterized developmental delays, intellectual disability, behavioral issues, macrocephaly, craniofacial features (such as brachycephaly, down slanted palpebral fissures, ptosis, high palate, large ears and others), hearing loss, distal muscle atrophy adolescence/adulthood, sparse body hair, altered glucose metabolism. As of 2020, only 52 individuals have been reported literature. We...
Abstract Background Higher drug levels and combination therapy with low-dose oral methotrexate (LD-MTX) may reduce anti-tumor necrosis factor (TNF) treatment failure in pediatric Crohn’s disease. We sought to (1) evaluate whether LD-MTX was associated higher anti-TNF levels, (2) associations between subsequent failure, (3) explore the effect of on maintenance remission among patients therapeutic (>5 µg/mL for infliximab >7.5 adalimumab). Methods conducted a post hoc analysis...
HLA DQA1*05 has been associated with the development of anti-drug antibodies (ADA) to tumor necrosis factor antagonists (anti-TNF) and treatment failure among adults Crohn's disease (CD). However, findings from other studies have inconsistent limited pediatric data.
Abstract Background Identifying minimally invasive diagnostic biomarkers that predict and monitor response to TNF inhibitors would enable treatment be personalized increase knowledge of the biological pathways associated with or lack thereof. Methods Children adolescents Crohn’s disease who started infliximab (IFX) were enrolled in a prospective, multi-center (n=6) trial identify IFX. Electronic case report forms prepared by Studytrax (Macon, GA). Subjects <18 years age diagnosed...
Objective: To implement a quality improvement based system to measure and improve data in an observational clinical registry support Learning Healthcare System.Data Source: ImproveCareNow Network registry, which as of September 2019 contained from 314,250 visits 43,305 pediatric Inflammatory Bowel Disease (IBD) patients at 109 participating care centers.Study Design: The impact centers was evaluated using statistical process control methodology. Data measures were defined, performance...
Abstract HPS has been described in 9–20% of children with end‐stage liver disease. We present a case previously, asymptomatic nine‐yr‐old incidentally found to have low oxygen saturation. Physical exam was remarkable for digital clubbing, splenomegaly and orthodeoxia. Laboratory evaluation revealed platelet count, hyperammonemia, prolonged coagulation studies. Sonography showed evidence portal venous hypertension. High resolution CT thorax CTA were normal. confirmed by agitated saline...
A 17-year-old Caucasian male previously healthy presents with a 4-month history of persistent dry cough, dyspnea exertion, and dyspepsia. chest X-ray showed no acute disease. Empiric asthma therapy fluticasone was ineffective. He treated for possible gastroesophageal reflux ranitidine, followed by pantoprazole, still improvement in symptoms. Another done worsening nighttime cough revealed bilateral patchy infiltrates, suggestive atypical pneumonia. 5 days azithromycin clinical improvement....