A5011895268- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Pharmaceutical studies and practices
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Autoimmune and Inflammatory Disorders Research
- Innovations in Medical Education
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Gastrointestinal motility and disorders
- Clinical Reasoning and Diagnostic Skills
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Respiratory and Cough-Related Research
- Viral-associated cancers and disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Porphyrin Metabolism and Disorders
- Digestive system and related health
- Folate and B Vitamins Research
Nemours Children's Health System
2021-2025
Alfred I. duPont Hospital for Children
2006-2022
Dupont Hospital
2013-2021
Thomas Jefferson University
2020-2021
DuPont (United States)
2006-2020
SUNY Downstate Health Sciences University
1998-2002
Children's Medical Center
1996
Whether or not populations diverge with respect to the genetic contribution risk of specific complex diseases is relevant understanding evolution susceptibility and origins health disparities. Here, we describe a large-scale whole-genome sequencing study inflammatory bowel disease encompassing 1,774 affected individuals 1,644 healthy control Americans African ancestry (African Americans). Although no new loci for are discovered at genome-wide significance levels, identify numerous instances...
INTRODUCTION: Evidence about specific carbohydrate diet (SCD) for inflammatory bowel disease (IBD) is limited. We conducted 54 single-subject, double-crossover N-of-1 trials comparing SCD with a modified (MSCD) and each the participant's baseline, usual (UD). METHODS: Across 19 sites, we recruited patients aged 7–18 years IBD active inflammation. Following 2-week baseline (UD), were randomized to 1 of 2 sequences 4 alternating 8-week MSCD periods. Outcomes included fecal calprotectin...
Functional dyspepsia (FD) is a disorder of the gut-brain interaction characterized by epigastric pain, nausea, and/or early satiety. Existing literature suggests physical link between psychiatric diagnoses and disorders at intestinal mast cells (MC) via corticotropin-releasing hormone (CRH) its intestinally located receptors (CRHR1/CRHR2). Our study aimed to further clarify physiologic connection pediatric illness FD. Study subjects were identified classified into three groups. The FD group...
Abstract Context Elevated concentrations of branched-chain amino acids (BCAA) are strong predictors type 2 diabetes mellitus (T2DM). Their association with cardiovascular disease (CVD) remains uncertain, particularly in youth. Objective We investigated the role BCAA and aromatic (AAA) obesity, their relationships novel biomarkers CVD, response to a physical activity-based lifestyle intervention (PAL-I) randomized controlled study youth normal weight (NW) obesity (OB). Methods Age (14-18...
INTRODUCTION: Obesity is common among patients with pediatric Crohn's disease (PCD). Some adult studies suggest obese respond less well to anti-tumor necrosis factor (TNF) treatment. This study sought compares anti-TNF response and levels between normal high body mass index (BMI). METHODS: The COMBINE trial compared monotherapy combination therapy methotrexate in PCD. In this secondary analysis, a comparison of time-to-treatment failure BMI vs Z -score >1, adjusting for prescribed...
The rs641738 C>T in membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is implicated, along with the rs738409 C>G polymorphism patatin-like phospholipase 3 (PNPLA3), nonalcoholic fatty liver disease (NAFLD). association of these polymorphisms and NAFLD are investigated Hispanic children obesity.Obese without were enrolled at a pediatric tertiary care health system genotyped for MBOAT7 PNPLA3 C>G. was characterized by ultrasonographic presence hepatic steatosis persistently...
BACKGROUND Spontaneous gastric perforation is a rare clinical disorder. The majority of the available data have been reported in neonatal age group. There are few cases spontaneous preschool children. To our knowledge, there no published information on older children and adolescents. CASE REPORT We describe presentation course two adolescent who presented with perforation. Both acute onset abdominal pain, which progressively worsened. In both cases, patient were taken urgently to operating...
The aim of this study was to compare the hemodynamic parameters from anesthesia records children who underwent upper gastrointestinal endoscopy (esophagogastroduodenoscopy [EGD]) with and without secretin pancreatic function tests (sPFTs).The were retrieved an electronic database. group consisted 186 children, age- sex-matched control included 136 patients did not have sPFTs.There no difference in demographic (age sex) between 2 groups. had a lower height body mass index. sPFT resulted...
<b><i>Background:</i></b> Inflammatory bowel disease (IBD) is a chronic relapsing that requires evaluation using multiple objective tools. In Europe, ultrasound (US) widely accepted modality used for the management of patients with IBD; however, its use in North America has only recently emerged as potential technique. <b><i>Objectives:</i></b> Our goal was to identify current practice patterns pediatric gastroenterologists and radiologists US...
Abstract Aim Gastro‐oesophageal reflux is routinely diagnosed with invasive intraluminal impedance pH probe monitoring. This study aimed to determine whether gastric pepsin A detected in saliva of children correlates gastro‐oesophageal reflux. Methods Patients undergoing monitoring were prospectively recruited between 2014 and 2016 at a paediatric hospital. Standard demographic data obtained from electronic medical records. Salivary samples collected during measured for an enzyme‐linked...
Endoscopic pancreatic function test (ePFT) has been in use for exocrine testing since the 1990s. In patients, short ePFT assesses acinar function, unlike longer version ductal adults. The present study summarizes characteristics of 1913 ePFTs (S-ePFT) performed at 2 centers 2001.The main indications patients presenting ages infancy to 24.3 years, S-ePFT were failure thrive, weight loss, diarrhea, and abdominal pain with bloating. Secretin was administered as bolus, 4 aliquots fluid collected...
This study aimed to determine whether mRNA expression of oncostatin-M (OSM) and its receptor (OSMR) in initial, pre-treatment intestinal biopsies is predictive response tumor necrosis factor antagonists (anti-TNF) a pediatric inflammatory bowel disease (IBD) cohort. Secondary outcomes correlated OSM OSMR with demographic variables; IBD type, extent, phenotype, severity; laboratory values; endoscopic findings.A retrospective chart review was conducted on 98 patients. Patients' clinical...
Abstract Objectives The incidence of eosinophilic esophagitis (EoE) is 3−5 times greater in patients with inflammatory bowel disease (IBD) compared the general population. This study aimed to differentiate true EoE from esophageal eosinophilia IBD by evaluating expression major basic protein (MBP) and interleukin‐13 (IL‐13) biopsies. Methods retrospective included subjects who had an esophagogastroduodenoscopy biopsies for work up or suspicion EoE. Patients were classified into 5 groups: ≥15...
HLA DQA1*05 has been associated with the development of anti-drug antibodies (ADA) to tumor necrosis factor antagonists (anti-TNF) and treatment failure among adults Crohn's disease (CD). However, findings from other studies have inconsistent limited pediatric data.
The objective of this project was to assess a pediatric institution's use infliximab and develop evaluate electronic health record tools improve safety efficiency ordering through auditing improved communication.Best defined literature review, analysis baseline at our institution, distribution national survey. Auditing order communication were optimized implementation mandatory indications in the orderable creation an interactive flowsheet that collects discrete free-text data. value...
X-linked lymphoproliferative syndrome type 2 (XLP2) is a rare genetic primary immunodeficiency disease caused by mutations in the
BackgroundInfliximab is a chimeric monoclonal antibody against tumor necrosis factor α approved for the induction and maintenance of remission in Crohn's disease (CD) ulcerative colitis (UC). Loss response to medication clinical challenge has been associated with drug immunogenicity formation antibodies infliximab (ATI). Reported ATI prevalence literature anywhere from 8% 60%. The role premedication corticosteroids preventing potentially infusion reactions controversial poorly studied...
We present the case of an 8 month old female with 15q deletion and chronic colitis. She was born at 32 weeks gestation, discharged home 2 after delivery on breast milk. readmitted 6 life diarrhea containing streaks blood mucous. The initially responded to elemental formula. presented again hospital 9 poor feeding, weight loss, vomiting bloody stools. A full septic workup performed that normal. Stool infectious studies were negative. underwent EGD flexible sigmoidoscopy which demonstrated a...