A5049151282- Immune Cell Function and Interaction
- Inflammatory Bowel Disease
- Microscopic Colitis
- Gut microbiota and health
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Helicobacter pylori-related gastroenterology studies
- Immunotherapy and Immune Responses
- Eosinophilic Esophagitis
- Immune Response and Inflammation
- Infant Nutrition and Health
- Liver Diseases and Immunity
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Food Allergy and Anaphylaxis Research
- Escherichia coli research studies
- Immunodeficiency and Autoimmune Disorders
- Viral gastroenteritis research and epidemiology
- Asthma and respiratory diseases
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders
- Probiotics and Fermented Foods
- Neonatal Respiratory Health Research
- Transgenic Plants and Applications
- Inflammatory mediators and NSAID effects
Washington University in St. Louis
2016-2025
Matsumoto Dental University
2019
University of Toronto
2019
Case Western Reserve University
2019
National Institutes of Health
2019
Applied Mathematics (United States)
2018
Stony Brook University
2018
Pediatrics and Genetics
2018
Stony Brook University Hospital
2018
Cincinnati Children's Hospital Medical Center
2018
Antibiotic use is associated with an increased risk of developing multiple inflammatory disorders, which in turn are linked to alterations the intestinal microbiota. How these microbiota translate into for responses largely unknown. Here we investigated whether and how antibiotics promote inflammation via translocation live native gut commensal bacteria.Oral were given wildtype induced mutant mouse strains, effects on bacterial translocation, susceptibility colitis evaluated. The sources...
The delivery of luminal substances across the intestinal epithelium to immune system is a critical event in surveillance, resulting tolerance dietary antigens and immunity pathogens. How this process regulated largely unknown. Recently goblet cell-associated antigen passages (GAPs) were identified as pathway delivering underlying lamina propria (LP) dendritic cells steady state. Here, we demonstrate that (GCs) form GAPs response acetylcholine (ACh) acting on muscarinic ACh receptor 4. GAP...
Bacterial antigen encounter in a preweaning interval is critical for developing antigen-specific tolerance to gut bacteria.
Group 3 ILCs (ILC3s) are innate sources of IL-22 and IL-17 include lymphoid tissue-inducer (LTi)-like NKp46(+) subsets. Both depend on RORγt aryl hydrocarbon receptor, but NKp46(+)ILC3s also require Notch T-bet for their development transcriptionally distinct. The extent to which these subsets have unique functions, especially in the context T cell- B cell-sufficient mice, remains largely unclear. To investigate specific function among other ILC3 cells, we generated mice selectively lacking...
Abstract The gastrointestinal mucosa contains a complex network of lymphoid compartments that have evolved to efficiently protect the host from invading pathogens. Recently, an additional structure resembling Peyer’s patches (PP) in composition and architecture has been identified murine small intestine, isolated follicle (ILF). In this study we examine nature factors required for ILF formation. We observed spectrum structures fitting previous descriptions ILFs, ranging clusters B220+ cells...
<h3>Background</h3> There is an increased prevalence of osteoporosis among patients with celiac disease. However, the relative disease osteoporotic and nonosteoporotic populations not known, benefit screening population for remains controversial. <h3>Methods</h3> We evaluated 840 individuals, 266 574 without osteoporosis, from Washington University Bone Clinic by serologic Individuals positive test results antitissue transglutaminase or antiendomysial antibody were offered endoscopic...
A specific interaction between the class I major histocompatibility complex molecule Kb and thymocytes expressing antigen receptor from cytolytic T lymphocyte 2C enhances maturation of cells CD8 lineage in transgenic mice. By analyzing mice backcrossed to Kbm mutant strains mice, we have identified five bm mutations antigen-encoding gene that alter positive selection induced by antigen. Compared with Kb, Kbm10 Kbm1 did not induce significant T-cell receptor-bearing thymocytes, Kbm8...
Helicobacter in the intestine induce regulatory T cells during homeostasis and effector colonic inflammation.