A5101761974- Inflammatory Bowel Disease
- Cytokine Signaling Pathways and Interactions
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Viral gastroenteritis research and epidemiology
- CAR-T cell therapy research
- Digestive system and related health
- Animal Virus Infections Studies
- Blood Coagulation and Thrombosis Mechanisms
- Autoimmune and Inflammatory Disorders
- Cellular Mechanics and Interactions
- Animal Genetics and Reproduction
- Gastrointestinal motility and disorders
- Autoimmune and Inflammatory Disorders Research
- Microbial infections and disease research
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Genetic Mapping and Diversity in Plants and Animals
- Hepatitis Viruses Studies and Epidemiology
- Hematological disorders and diagnostics
- Protein Tyrosine Phosphatases
- Glioma Diagnosis and Treatment
MaineGeneral Medical Center
2012-2023
Massachusetts General Hospital
2012-2023
Harvard University
2012-2022
Boston Children's Hospital
2012
American Society for Gastrointestinal Endoscopy
2012
Saint John's Health Center
2011
Wayne and Gladys Valley Foundation
2011
Thomas Cole Historic House
2011
University of New Haven
2011
St Vincent's Health
2008
Interleukin-10 (IL-10) signaling genes are attractive inflammatory bowel disease (IBD) candidate as IL-10 restricts intestinal inflammation, polymorphisms have been associated with IBD in genome-wide association studies, and mutations receptor (IL-10R) reported immunodeficient children severe infantile-onset IBD. Our objective was to determine if IL-10R were early-onset (EO-IBD) very-early-onset (VEO-IBD).Candidate-gene analysis of IL10RA IL10RB performed after initial sequencing an...
The relationship between the host and its microbiota is challenging to understand because both microbial communities their environments are highly variable. We have developed a set of techniques based on population dynamics information theory address this challenge. These methods identify additional bacterial taxa associated with pediatric Crohn disease can detect significant changes in fewer samples than previous statistical approaches required. also substantially improved accuracy...
Inflammatory Bowel Disease (IBD) is a chronic autoimmune inflammatory disease of the intestine which can lead to malnutrition, poor quality life, and colon cancer.(1-4) Although there no cure for disease, clinical remission primary goal.(5) The Center at MassGeneral Hospital Children (MGHfC) adopted Previsit Planning (PVP) model identify discuss symptomatic patients prior their appointments specific issues that impact management.(6-8) Registry from ImproveCareNow (ICN), international Quality...
The purpose of this study was to investigate the MR enterographic findings that best correlate with mucosal healing assessed ileocolonoscopy.Patients Crohn disease who underwent two ileocolonoscopic examinations and also enterography close in time second endoscopic examination were included a retrospective study. Two pediatric gastroenterologists blinded imaging reviewed assess for healing, defined as resolution inflammation within bowel segment at subsequent ileocolonoscopy. radiologists...
Endoscopic mucosal improvement is the gold standard for assessing treatment efficacy in clinical trials of Crohn's disease. Current endoscopic indices are not routinely used practice. The lack information large registries limits their use research. A quick, easy, and accurate method needed clinicians real-world We developed tested a novel simplified assessment disease (SEMA-CD).We 5-point scale ranking severity ileum colon based on Simple Score (SES-CD). Central readers were trained to...
ABSTRACT Objectives: Experimental studies have shown that vitamin D has an immunomodulatory effect on the innate and adaptive immune systems. Associations between deficiency development or progression of inflammatory bowel diseases (IBDs) are reported, but a cause-and-effect relationship pretreatment 25 hydroxyvitamin [25(OH)D] levels response to anti-tumor necrosis factor-α (anti-TNF) therapy is not established. Methods: This retrospective study evaluated pediatric IBD patients who had...
Background MR enterography (MRE) is the primary modality for evaluating small bowel disease in pediatric Crohn's patients. Standard clinical practice includes imaging patients at diagnosis and during symptomatic recurrence. The role MRE surveillance of asymptomatic has not yet been established. Purpose To determine whether features are associated with Study Type Retrospective. Populations Pediatric who underwent while asymptomatic, defined by gastroenterologists using a physician global...
Abstract Genome-wide association studies (GWAS) have identified hundreds of loci associated with Crohns disease (CD), however, as all complex diseases, deriving pathogenic mechanisms from these non-coding GWAS discoveries has been challenging. To complement and better define actionable biological targets, we analysed sequenced data more than 30,000 CD patients 80,000 population controls. We observe rare coding variants in established susceptibility genes well ten where variation directly...
Background and aims Mesalamine is commonly used to treat ulcerative colitis (UC). Although mesalamine acts topically, in vitro data suggest that intracellular transport required for its beneficial effect. Genetic variants mucosal proteins may affect this uptake, but the clinical relevance of these has not been studied. The aim study was determine whether genes involved cellular response UC. Methods Subjects with UC from a 6-week trial using multiple doses were genotyped genome-wide array...
C-reactive protein (CRP) is a serum marker that used to measure disease activity in Crohn's (CD). However, subset of CD patients have normal CRP during flares. In rheumatoid arthritis and lupus, genetic variants can restrict elevations This study sought determine if common affect values active CD.Subjects with who participated the Partners HealthCare BioBank were genotyped for 5 (rs2794520, rs3122012, rs3093077, rs2808635, rs1800947). Medical records reviewed highest value CD. infection or...
Granulomas are a pathologic hallmark of Crohn disease (CD) although they found in only subset patients. Well-formed granulomas associated with an aggressive phenotype it is unknown if microgranulomas confer similar phenotype. This study sought to define the incidence pediatric CD and compare clinical course cases those without granulomatous inflammation.We performed single-center, retrospective patients who had at least 3 years follow-up. initial diagnostic biopsies were systematically...