A5048675008- Inflammatory Bowel Disease
- Microscopic Colitis
- Adolescent and Pediatric Healthcare
- Infant Nutrition and Health
- Healthcare Policy and Management
- Immunodeficiency and Autoimmune Disorders
- Emergency and Acute Care Studies
- Monoclonal and Polyclonal Antibodies Research
- Diet and metabolism studies
- Glycosylation and Glycoproteins Research
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Liver Disease Diagnosis and Treatment
- Digestive system and related health
- Viral gastroenteritis research and epidemiology
- Asthma and respiratory diseases
- Celiac Disease Research and Management
- Appendicitis Diagnosis and Management
- Colorectal Cancer Screening and Detection
- Primary Care and Health Outcomes
- Clinical Nutrition and Gastroenterology
- Anorectal Disease Treatments and Outcomes
- Congenital Heart Disease Studies
- Sexuality, Behavior, and Technology
- Pregnancy and Medication Impact
Massachusetts General Hospital
2012-2024
Harvard University
2005-2024
MaineGeneral Medical Center
2010-2021
Boston Children's Hospital
1988-2018
Pediatrics and Genetics
2017
Harvard University Press
1996-2010
University of Utah
2007-2009
Nutrition 21 (United States)
1996
Ann Arbor Center for Independent Living
1991
University of Michigan
1991
Maternal IgG is transferred to the suckling mouse and rat through a major histocompatibility complex (MHC) class I‐related Fc receptor (FcRn) on brush border of proximal small intestine. We have previously described site epithelial surface human fetal intestine with binding characteristics similar FcRn. report here identification by reverse transcriptase polymerase chain reaction amplification sequencing orthologue FcRn in tissue obtained from adult protein was detected western blot....
The mechanisms that regulate immunoglobulin G (IgG) catabolism are little understood. We have previously found unusually low IgG concentrations in sera of mice homozygous for a targeted disruption the β 2 ‐microglobulin gene. therefore investigated whether this might result, at least part, from increased clearance systemic circulation lacking ‐microglobulin. compared half‐lives radiolabelled mouse IgG1 injected intravenously into −/− and wild‐type or heterozygous siblings. 125 I‐labelled was...
Obesity is a significant public health threat to children in the United States. The aims were to: 1) Determine prevalence of obesity multicenter cohort with inflammatory bowel disease (IBD); 2) Evaluate whether overweight and obese status associated patient demographics or characteristics.We used data from ImproveCareNow Collaborative for pediatric IBD, registry collected between April 2007 December 2009. Children ages 2-18 years classified into body mass index (BMI) percentiles. Bivariate...
Abstract There is considerable evidence to suggest that an FcR similar in structure class I MHC Ags, neonatal Fc receptor (FcRn), transports IgG across the intestinal epithelium of suckling mice. However, this has not previously been shown definitively, nor it whether FcRn only, or even major, transporter mouse gut. We report here mice homozygous for a targeted disruption beta 2microglobulin (beta 2m) gene, which encodes one subunit FcRn, had reduced alpha-chain at lumenal plasma membrane...
OBJECTIVE. The objectives of this study were prospective evaluation MR enterographic accuracy for detecting Crohn disease imaging features in pediatric patients, compared with a CT reference standard, as well determination active bowel inflammation and fibrosis using histologic standard.
The goal was to compare the predictive values of Prometheus Inflammatory Bowel Disease (IBD) Serology 7 (IBD7) panel (Prometheus Laboratories, San Diego, CA) with routine blood tests in a population children referred for initial evaluation suspected IBD.Medical records pediatric patients IBD whom IBD7 testing performed at Laboratories between January 2006 and November 2008 were reviewed. Patients underwent diagnosis by gastroenterologists on basis clinical, radiologic, endoscopic, pathologic...
ImproveCareNow (ICN) is the largest pediatric learning health system in nation and started as a quality improvement collaborative. To test feasibility validity of using ICN data for clinical research, we evaluated effectiveness anti-tumor necrosis factor-α (anti-TNFα) agents management Crohn disease (CD).Data were collected 35 gastroenterology practices (April 2007 to March 2012) analyzed sequence nonrandomized trials. Patients who had moderate severe CD classified initiators or...
Abstract Introduction The objective of this study was to evaluate the feasibility shear wave elastography ( SWE ), as a non‐invasive means assessing liver fibrosis stage in paediatric and adolescent patients. Materials Methods Consecutive subjects scheduled for biopsy LB ) evaluation known or suspected diffuse disease were included after informed guardian consent subject assent IRB ‐approved single institution study. Elastograms acquired prior biopsy, from under breath‐hold normal...
BACKGROUND AND OBJECTIVES: Emergency department (ED) utilization is a major driver of health care costs. Specialist physicians have an important role in addressing ED utilization, especially at highly specialized, academic medical centers. We sought to investigate whether reporting specialist can decrease visits. METHODS: This study analyzed intervention reduce among patients who were followed by pediatric gastroenterologists. In May 2013, each gastroenterologist began receiving reports with...
Inflammatory Bowel Disease (IBD) is a chronic autoimmune inflammatory disease of the intestine which can lead to malnutrition, poor quality life, and colon cancer.(1-4) Although there no cure for disease, clinical remission primary goal.(5) The Center at MassGeneral Hospital Children (MGHfC) adopted Previsit Planning (PVP) model identify discuss symptomatic patients prior their appointments specific issues that impact management.(6-8) Registry from ImproveCareNow (ICN), international Quality...
Abstract Background Cessation of statural growth occurs with radiographic closure the plates, radiographically defined as bone age (BA) 15 years in females and 17 males. Methods We determined frequency continued compared total height gain beyond time expected plate chronological at achievement final adult Crohn’s disease (CD) vs ulcerative colitis (UC) described velocity curves inflammatory bowel (IBD) children National Health Nutrition Examination Survey (NHANES). identified all older than...
It has been noted that the closure of intestinal barrier to immunoglobulins is a normal maturational process in rat. also microvillus membrane (MVM) newborn animals differs from adult MVM. The purpose this study document whether thyroid hormone can induce vivo rat and relate effect thyroxine structural functional maturation To assess closure, 2-wk-old rats were fed immunoglobulin G (IgG), serum antibody binding activity was measured 4 h later. treated (T) 1.5-2 times less than controls (C)...
Nephropathy is the most severe complication of diabetes mellitus. We investigated effect exogenous growth hormone (GH) administration on renal function and matrix deposition in streptozotocin (STZ) model type I-diabetic rat.Adult female STZ-diabetic rats (D), non-diabetic control injected with saline (C) diabetic bovine GH for 3 months (CGH DGH, respectively) were used.The usual hypertrophy seen D animals was more pronounced DGH group. Creatinine clearance increased only rats, but not other...
ABSTRACT Objectives: Experimental studies have shown that vitamin D has an immunomodulatory effect on the innate and adaptive immune systems. Associations between deficiency development or progression of inflammatory bowel diseases (IBDs) are reported, but a cause-and-effect relationship pretreatment 25 hydroxyvitamin [25(OH)D] levels response to anti-tumor necrosis factor-α (anti-TNF) therapy is not established. Methods: This retrospective study evaluated pediatric IBD patients who had...
A 5-year-old boy was admitted to the hospital because of headaches, abdominal pain, increasing girth, and a rash. Five months earlier, intermittent severe headaches pain had developed, papilledema found. MRI disclosed bilateral subdural hygromas, which required placement subdural–peritoneal shunt, at time ascites noted. Headaches, gradually worsened, rash developed. Diagnostic procedures were performed.