A5076412146- Inflammatory Bowel Disease
- Breast Cancer Treatment Studies
- Microscopic Colitis
- Acute Lymphoblastic Leukemia research
- Breast Implant and Reconstruction
- Adolescent and Pediatric Healthcare
- Clostridium difficile and Clostridium perfringens research
- Advanced Radiotherapy Techniques
- Liver Disease and Transplantation
- Pregnancy and Medication Impact
- Eosinophilic Esophagitis
- Celiac Disease Research and Management
- Appendicitis Diagnosis and Management
- Viral gastroenteritis research and epidemiology
- Gastrointestinal disorders and treatments
- Breast Lesions and Carcinomas
- Diverticular Disease and Complications
- Autoimmune and Inflammatory Disorders
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Pancreatitis Pathology and Treatment
- Advances in Oncology and Radiotherapy
- Immunodeficiency and Autoimmune Disorders
- Histiocytic Disorders and Treatments
- Parvovirus B19 Infection Studies
University of Maryland, Baltimore
2012-2024
Gazipur Agricultural University
2024
University of Maryland Medical Center
2020-2021
Leidos (United States)
2016
Frederick National Laboratory for Cancer Research
2016
BC Cancer Agency
2005-2011
Sinai Hospital
2005-2009
University of British Columbia
2005-2008
University of Victoria
2008
Boston Children's Hospital
2005
Mucosal-associated invariant T (MAIT) cells represent a class of antimicrobial innate-like that have been characterized in human blood, liver, lungs, and intestine. Here, we investigated, for the first time, presence MAIT stomach children, adults, elderly undergoing routine endoscopy assessed their reactivity to Helicobacter pylori (H. - Hp), major gastric pathogen. We observed are present lamina propria compartment display similar memory phenotype blood cells. then demonstrated able...
Cytokines and growth factors play a major role in the dysregulated immune response inflammatory bowel disease (IBD). We hypothesized that significant differences exist between serum cytokine factor profiles of pediatric IBD patients with active (AD) those remission, levels some these soluble mediators may be used to define regulators determine activity.Eighty-eight consecutive confirmed Crohn's (CD) ulcerative colitis (UC) seen at Duke Children's Hospital were prospectively enrolled sample...
T cells are the main orchestrators of protective immunity in stomach; however, limited information on presence and function gastric subsets is available mainly due to difficulty recovering high numbers viable from human biopsies. To overcome this shortcoming we optimized a cell isolation method that yielded lamina propria mononuclear (LPMC) Classic memory were identified LPMC compared peripheral blood (PBMC) obtained children, adults, elderly using an 14 color flow cytometry panel. A...
Approximately, one-third to one-half of children with chronic granulomatous disease (CGD) develop gastrointestinal inflammation characteristic idiopathic inflammatory bowel (IBD), usually Crohn's disease. We hypothesized that the overall IBD genetic risk, determined by risk score (GRS), might in part determine development CGD. reviewed medical records establish diagnoses CGD subjects seen at NIAID. single nucleotide polymorphism genotypes were using Immunochip, and GRS estimated Mangrove....
Whether or not populations diverge with respect to the genetic contribution risk of specific complex diseases is relevant understanding evolution susceptibility and origins health disparities. Here, we describe a large-scale whole-genome sequencing study inflammatory bowel disease encompassing 1,774 affected individuals 1,644 healthy control Americans African ancestry (African Americans). Although no new loci for are discovered at genome-wide significance levels, identify numerous instances...
Variation in medical care can be a barrier to improving clinical outcomes. We aim describe the variation of Crohn disease as provided by broad sample pediatric gastroenterologists.Two hundred forty-six patients 93 gastroenterologists from 48 practice sites starting treatment with either thiopurine or infliximab were studied. assessed diagnostic testing that had been performed establish diagnosis and assess phenotype, extent, severity disease. also initial dosage nutritional...
Increased mortality risk because of severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) infection in adults with native liver disease (LD) and transplant (LT) is associated advanced age comorbid conditions. We aim to report outcomes for children LD LT enrolled the NASPGHAN/SPLIT SARS-CoV2 registry.
The effectiveness of 6-mercaptopurine combined with azathioprine in treating severe ulcerative colitis has been shown several adult studies. Reported pediatric experiences are rare. purpose this study was to investigate the safety and potential efficacy treatment active a population.The medical records patients who were under observation at Children's Hospital Philadelphia its satellite clinics from January 1984 through December 1997 retrospectively reviewed. Patients included had received...
6-mercaptopurine (6-MP) and azathioprine (AZA) are used to treat inflammatory bowel disease (IBD). Side effects include infection, leukopenia, hepatitis, pancreatitis. The level of thiopurine methyltransferase (TPMT), which metabolizes 6-MP 6-methylmercaptopurine, may reflect the risk side effects. We sought evaluate relationship between these medications TPMT pediatric patients with IBD. medical records our who were diagnosed IBD received or AZA reviewed for measured levels. All red blood...
Tubular carcinoma of the breast (TCB) is a recognized histologic variant infiltrating ductal (IDC) and has been considered to have comparatively favorable prognosis. However, previous studies based on small numbers cases, some pure TCB mixed histology, or not employed an appropriate comparison group. In this study 171 cases group 386 with grade I (well differentiated) IDC were identified in population-based database maintained by British Columbia Cancer Agency (BCCA). The proportion axillary...
African Americans (AAs) are an admixed population of West (WA) and European ancestry (EA). Crohn's disease (CD) susceptibility genes have not been established. We therefore evaluated the contribution admixture major established risk to AA CD.Ninety-seven informative markers were genotyped for estimates using STRUCTURE. Overall, 354 CD cases ethnicity-matched controls total 21 single nucleotide polymorphisms (SNPs) in ATG16L1, NOD2, IBD5, IL23R IRGM by TaqMan or direct sequencing. Association...
Recurrence of Crohn's disease after surgery is a common occurrence, pointing to the need for strategy prevent recurrent disease. We report postoperative course 10 patients who required intestinal resections complications related disease.All had Pediatric Disease Activity Index score or greater. Among these patients, 5 began treatment with 6-mercaptopurine in perioperative period. All received various combinations prednisone and salicylate compounds. Patients were given did not discontinue...
Background Patients with inflammatory bowel disease (IBD) have an increased incidence of thromboembolic events. This risk may be caused by frequency thrombophilic mutations such as factor V Leiden G1691A (FVL), prothrombin G20210A (PT), or methylene tetrahydrofolate reductase C667T (MTHFR). Prevalence rates heterozygous in FVL, PT, and MTHFR are reported for whites (1.8%, 1.3%, 26.6%, respectively), blacks (0.8%, 0.3%, 12.4%, Hispanics (1.2%, 2.4%, 41.5%, respectively). We sought to...
Diabetes is a chronic and debilitating metabolic disorder that gradually impairs the body's ability to regulate blood sugar levels, leading complications can affect multiple organs systems, including heart, kidneys, nerves, eyes. Chia seed contains high concentration of dietary fiber, omega-3 fatty acids, essential amino which may have hypotensive, hypoglycemic, anticholesterolemic benefits. The objective this research was investigate whether administration chia extract (CSE) reduce...
The site for percutaneous liver biopsy is determined by physical examination and anatomic landmarks. authors compared with ultrasound to determine location, size, an optimal site.A pediatric gastroenterology fellow or attending gastroenterologist initially selected a examination. An ultrasonographer performed limited evaluate this site.Sixty sites from 58 patients were evaluated. Forty-six had no previous surgery. Two Kasai procedure. Ten orthotopic transplantation. mean age of the was 11.1...
Langerhans' cell histiocytosis (LCH) may have many clinical manifestations and has a varied presentation (1,2). Eighty percent of patients skeletal involvement, 50% dermatologic changes, 30% lymphadenopathy, 20% hepatosplenomegaly, 10% to 15% pulmonary infiltrates (3). Other findings include anemia, thrombocytopenia, exophthalmos, gingival appearance that mimic yeast infection, pituitary dysfunction Gastrointestinal in LCH failure thrive, with vomiting diarrhea secondary intestinal...
Retrocecal appendicitis is uncommon and potentially difficult to diagnose. A ruptured retrocecal appendix may wall itself off, become asymptomatic, then develop into a symptomatic abscess with fever, diarrhea, nausea. The development of portal-mesenteric venous thrombosis-thrombus pylephlebitis, however, much rarer complication (1-7). During an acute Epstein-Barr virus (EBV) infection, 15.5-year-old boy transient vomiting, diarrhea had portal vein mesenteric thrombi caused by perforated...