A5019678358- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Autoimmune and Inflammatory Disorders
- IL-33, ST2, and ILC Pathways
- Gastrointestinal Bleeding Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Gastric Cancer Management and Outcomes
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- MicroRNA in disease regulation
- Celiac Disease Research and Management
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Health Systems, Economic Evaluations, Quality of Life
- Liver Diseases and Immunity
- Circular RNAs in diseases
- Pharmaceutical studies and practices
- Diverticular Disease and Complications
- Tuberculosis Research and Epidemiology
- Digestive system and related health
- Gastrointestinal motility and disorders
Baylor Scott & White Medical Center - Temple
2024
Baylor Scott & White Health
2018-2024
Perrigo (United States)
2024
Bristol-Myers Squibb (Switzerland)
2024
Entasis Therapeutics (United States)
2024
AbbVie (United States)
2024
Pfizer (United States)
2024
Janssen (Belgium)
2024
Aurobindo Pharma (United States)
2024
Dr. Reddy's Laboratories (United States)
2024
The inflammatory bowel diseases Crohn's disease and ulcerative colitis are common, chronic disorders that cause abdominal pain, diarrhea, gastrointestinal bleeding. To identify genetic factors might contribute to these disorders, we performed a genome-wide association study. We found highly significant between the IL23R gene on chromosome 1p31, which encodes subunit of receptor for proinflammatory cytokine interleukin-23. An uncommon coding variant (rs11209026, c.1142G>A, p.Arg381Gln)...
Crohn's disease (CD) and ulcerative colitis (UC) are associated with expression differences in genes involved immune function, wound healing, tissue remodeling. MicroRNAs (miRNAs) small, noncoding RNAs that act as potent negative regulators of gene differentially expressed chronic inflammatory diseases, including UC. We examined the miRNAs tissues from different intestinal regions patients active ileal colonic CD.Colonoscopic pinch biopsies were obtained terminal ileum, cecum, transverse...
Nuclear Factor-κB (NF-κB) is a major transcription regulator of immune response, apoptosis and cell-growth control genes, upregulated in inflammatory bowel disease (IBD), both ulcerative colitis (UC) Crohn's disease. The NFKB1 gene encodes the NF-κB p105/p50 isoforms. Genome-wide screens IBD families show evidence for linkage on chromosome 4q where maps. We sequenced promoter, exon 1 all coding exons 10 probands two controls, identified six nucleotide variants, including common...
OBJECTIVES Inflammatory bowel disease (IBD), comprising primarily of Crohn's (CD) and ulcerative colitis (UC), is increasingly prevalent in racial ethnic minorities. This study was undertaken to characterize differences phenotype a predominantly adult population. METHODS Phenotype data on 830 non-Hispanic white, 127 African American, 169 Hispanic IBD patients, recruited from six academic centers, were abstracted medical records compiled the NIDDK-IBD Genetics Consortium repository. We...
Ulcerative colitis (UC) and Crohn's disease (CD) are inflammatory bowel diseases (IBD) with variable, overlapping clinical features complex pathophysiologies.To identify pathogenic processes underlying these subtypes, we used single endoscopic pinch biopsies to elucidate patterns of gene expression in active inactive areas UC CD compared infectious healthy control samples.Unsupervised classification a total 36 samples yielded promising separation between the affected IBD, unaffected non-IBD...
Multiple factors, particularly IBD family history, tobacco use, age at diagnosis and recently, NOD2 mutant genotypes may influence Crohn's disease (CD) heterogeneity. We performed a multicenter retrospective record analysis of 275 unrelated patients with CD. Age diagnosis, Jewish ethnicity, use surgical site clinical behavior were correlated for mutations, all risk factors assessed independent on outcomes site, surgery free survival. Risk ileal was increased CD two mutations (Odds Ratio,...
Recent epidemiological studies suggest that the prevalences of Crohn's disease (CD) and ulcerative colitis (UC) are increasing in United States. We sought to determine whether nationwide rates inflammatory bowel (IBD) hospitalizations have increased response temporal trends prevalence.We identified all admissions with a primary diagnosis CD or UC, 1 their complications Nationwide Inpatient Sample between 1998 2004. National estimates hospitalization surgery were determined using U.S. Census...
Variation in adherence to management guidelines for inflammatory bowel disease (IBD) suggests variable quality of care. Quality indicators (QIs) can be developed measure the structure, processes, and outcomes health care delivery. The RAND/UCLA appropriateness method was used develop a set process outcome QIs define IBD.Guidelines position papers IBD published from 2006 2011 were reviewed potential QIs, which rated by multidisciplinary panel. Potential discussed at 3 moderated in-person...
Objective Although perturbations in mitochondrial function and structure have been described the intestinal epithelium of Crohn’s disease ulcerative colitis patients, role epithelial stress pathophysiology inflammatory bowel diseases (IBD) is not well elucidated. Prohibitin 1 (PHB1), a major component protein inner membrane crucial for optimal respiratory chain assembly function, decreased during IBD. Design Male female mice with inducible cell deletion Phb1 ( iΔIEC ) or Paneth cell-specific...
OBJECTIVES: Although screening colonoscopy is effective in preventing distal colon cancers, effectiveness right-sided cancers less clear. Previous studies have reported that retroflexion the right improves adenoma detection. We aimed to determine whether a second withdrawal from vs. forward view alone leads detection of additional adenomas. METHODS: Patients undergoing or surveillance were invited participate parallel, randomized, controlled trial at two centers. After cecal intubation,...
BackgroundPatients with inflammatory bowel disease (IBD) are at increased risk of developing colorectal cancer. Aberrant microRNA (miR) expression has been linked to carcinogenesis; however, no reports document a relationship between IBD-related neoplasia (IBDN) and altered miR expression. In the current study we sought identify specific dysregulation along normal–inflammation–cancer axis.
Tricyclic antidepressants (TCAs) have efficacy in treating irritable bowel syndrome (IBS). Some clinicians use TCAs to treat residual symptoms inflammatory disease (IBD) patients already on decisive IBD therapy or with quiescent inflammation, although this strategy has not been formally studied.The aim of study was examine the TCA symptoms, despite controlled a retrospective cohort study.Inclusion required initiation for persistent gastrointestinal symptoms. had inactive mildly active...
Whether or not populations diverge with respect to the genetic contribution risk of specific complex diseases is relevant understanding evolution susceptibility and origins health disparities. Here, we describe a large-scale whole-genome sequencing study inflammatory bowel disease encompassing 1,774 affected individuals 1,644 healthy control Americans African ancestry (African Americans). Although no new loci for are discovered at genome-wide significance levels, identify numerous instances...
In two separate cohorts, intestinal resection for Crohn's disease was associated with reduced alpha diversity and increased Proteobacteria Bacteroidetes Firmicutes.Surgery also decreased abundance of bai operon genes secondary bile acids, including isoLCA.
Abstract Background Clinical and molecular subcategories of inflammatory bowel disease (IBD) are needed to discover mechanisms predictors response relapse. We aimed develop a study prospective adult research cohort with IBD (SPARC IBD) including longitudinal clinical patient-reported data biosamples. Methods established adults from geographically diverse sample patients across the United States standardized biosample collection methods processing techniques. At enrollment at time lower...
Previous genome-wide expression studies have highlighted distinct gene patterns in inflammatory bowel disease (IBD) compared to control samples, but the interpretation of these has been limited by sample heterogeneity with respect phenotype, activity, and anatomic sites. To further improve molecular classification phenotypes we focused on a single site, unaffected proximal ileal margin resected ileum, three that were unlikely overlap: Crohn's (ileal CD), ulcerative colitis (UC), patients...