A5067524409- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Eosinophilic Disorders and Syndromes
- Genetic factors in colorectal cancer
- Inflammatory Bowel Disease
- Celiac Disease Research and Management
- Gastroesophageal reflux and treatments
- Diverticular Disease and Complications
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Liver Diseases and Immunity
- Diagnosis and treatment of tuberculosis
- Autoimmune and Inflammatory Disorders
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- IL-33, ST2, and ILC Pathways
- Pancreatic and Hepatic Oncology Research
- AI in cancer detection
Pennsylvania State University
2025
University of Minnesota
2022-2024
The University of Texas Southwestern Medical Center
2015-2023
University of Minnesota Medical Center
2023
Diagnostics Research Group
2020-2021
Baylor College of Medicine
2016-2021
Inform (Germany)
2019-2021
Arizona Christian University
2019
BioSurfaces (United States)
2017
Southwestern Medical Center
2016
Most prior studies of primary diagnosis in surgical pathology using whole slide imaging (WSI) versus microscopy have focused on specific organ systems or included relatively few cases. The objective this study was to demonstrate that WSI is noninferior for pathology. A blinded randomized noninferiority conducted across the entire range cases (biopsies and resections, including hematoxylin eosin, immunohistochemistry, special stains) from 4 institutions original sign-out (baseline diagnosis)...
The normal content of eosinophils in the adult colon and criteria for histopathologic diagnosis eosinophilic colitis remain undefined. This study aimed at: (1) establishing numbers colon; (2) proposing a clinicopathologic framework primary colonic eosinophilia colitis. To accomplish these goals, we counted right, transverse, left 159 adults with histology. Using database 1.2 million patients biopsies, extracted all eosinophilia. We reviewed slides from cases captured demographic, clinical,...
Objective Although perturbations in mitochondrial function and structure have been described the intestinal epithelium of Crohn’s disease ulcerative colitis patients, role epithelial stress pathophysiology inflammatory bowel diseases (IBD) is not well elucidated. Prohibitin 1 (PHB1), a major component protein inner membrane crucial for optimal respiratory chain assembly function, decreased during IBD. Design Male female mice with inducible cell deletion Phb1 ( iΔIEC ) or Paneth cell-specific...
OBJECTIVES: During the past decades, prevalence of gastric and duodenal ulcers, as well Helicobacter pylori infection, has markedly declined. We hypothesized that decline in H. decreased fraction -positive ulcers. The present study was designed to test this hypothesis a large US population undergoing esophagogastro-duodenoscopy community-based endoscopy centers. METHODS: Inform Diagnostics database is national electronic repository histopathologic records patients distributed throughout...
Although large polyps are known to harbor more advanced neoplasia than small polyps, the extent of relationship between size and type is not fully known. The study aim was establish benchmarks for prevalence different histologic polyp types among varying categories.The Miraca Life Sciences Database an electronic repository histopathologic patient records from private practices throughout United States. We extracted 483,998 unique patients who underwent colonoscopy with polypectomy January...
It is unknown how the brain orchestrates coordination of global neural and vascular dynamics. We sought to uncover role a sparse but unusual population genetically-distinct interneurons known as type-I nNOS neurons, using novel pharmacological strategic unilaterally ablate these neurons from somatosensory cortex mice. Region-specific ablation produced changes in both activity dynamics, decreased power delta-band local field potential, reduced sustained responses prolonged sensory...
Alternatively spliced tissue factor (asTF) promotes neovascularization and monocyte recruitment via integrin ligation. While asTF mRNA has been detected in some pancreatic ductal adenocarcinoma (PDAC) cell lines increased expression can promote PDAC growth a subcutaneous model, the of protein bona fide lesions and/or its role metastatic spread are yet to be ascertained. We here report that is abundant lesional stromal compartments five studied types carcinoma including PDAC. Analysis 29...
d-2-hydroxyglutarate (D2HG) is produced in the tricarboxylic acid cycle and quickly converted to α-ketoglutarate by dehydrogenase (D2HGDH). In a mouse model of colitis-associated colon cancer (CAC), urine level D2HG during colitis correlates positively with subsequent polyp counts severity dysplasia. The i.p. injection results delayed recovery from severe tumorigenesis. colonic expression D2HGDH decreased ulcerative (UC) patients at baseline who progress cancer. Hypoxia-inducible factor...
Non-oesophageal gastrointestinal eosinophilic diseases (EGID) are considered rare. However, low disease awareness among clinicians and pathologists may contribute to underdiagnosis.To determine how frequently requests evaluate for EGID accompany biopsies in what proportion of suspected cases address these requests, either confirming or refuting the clinical suspicion.All which biopsy requisitions included an explicit suspicion were extracted from a large clinicopathologic database manually...
Paneth cell defects in Crohn’s disease (CD) patients (called the Type I phenotype) are associated with worse clinical outcomes. Recent studies have implicated mitochondrial dysfunction cells as a mediator of ileitis mice. We hypothesized that CD exhibit impaired health and mitochondrial-targeted therapeutics may provide novel strategy for ileal CD. Terminal mucosal biopsies from adult non-IBD were characterized phenotyping damage. To demonstrate response CD, treated vehicle or Mito-Tempo,...
Eosinophilic gastrointestinal diseases, specifically eosinophilic gastritis and duodenitis, are chronic inflammatory conditions characterized by persistent (GI) symptoms elevated levels of activated eosinophils in the GI tract. Both clinical endoscopic findings nonspecific, no or histopathologic diagnostic guidelines published, disease awareness is low, both among clinicians amongst pathologists, who tend to overlook mild moderate increases density biopsy specimens. Yet, evaluating and, at...
Environmental factors associated with ethnicity may contribute to the occurrence of eosinophilic esophagitis. Our study aimed investigate influence Helicobacter pylori on ethnic variation esophageal eosinophilia in a large national sample patients undergoing esophago-gastro-duodenoscopy.The Miraca Life Sciences Database is an electronic repository histopathologic patient records. A case-control evaluated and how age, gender, histologic diagnosis H. modify this relationship.The total...