A5008594569- Health Systems, Economic Evaluations, Quality of Life
- Primary Care and Health Outcomes
- Inflammatory Bowel Disease
- Patient-Provider Communication in Healthcare
- HIV/AIDS Research and Interventions
- Microscopic Colitis
- HIV, Drug Use, Sexual Risk
- Rheumatoid Arthritis Research and Therapies
- Pancreatic function and diabetes
- Diabetes Management and Education
- Palliative Care and End-of-Life Issues
- Chronic Disease Management Strategies
- Cancer Genomics and Diagnostics
- Healthcare Policy and Management
- BRCA gene mutations in cancer
- Innovations in Medical Education
- Diabetes and associated disorders
- Economic and Financial Impacts of Cancer
- Chronic Myeloid Leukemia Treatments
- Emergency and Acute Care Studies
- Healthcare cost, quality, practices
- Biosimilars and Bioanalytical Methods
- Nursing Diagnosis and Documentation
- Advanced Breast Cancer Therapies
- Mobile Health and mHealth Applications
American Nurses Association
2023
University of Fort Lauderdale
2020
University of Miami
2011-2019
Sapir College
2017
John Wiley & Sons (Germany)
2015
Prime University
2015
Bloomberg (United States)
2012
Johns Hopkins University
2012
Bar-Ilan University
2005-2007
Sheba Medical Center
2005-2007
Shortage in tissue availability from cadaver donors and the need for life-long immunosuppression severely restrict large-scale application of cell-replacement therapy diabetic patients. This study suggests potential use adult human liver as alternate autologous beta-cell-replacement therapy. By using pancreatic duodenal homeobox gene 1 (PDX-1) soluble factors, we induced a comprehensive developmental shift cells into functional insulin-producing cells. PDX-1-treated express insulin, store it...
The transplantation of human embryonic stem cell (hESC)-derived insulin-producing β cells for the treatment diabetes is finally approaching clinical stage. However, even with state-of-the-art differentiation protocols, a significant percentage undefined non-endocrine types are still generated. Most importantly, there potential carry-over non-differentiated that may produce teratomas. We sought to modify hESCs so their differentiated progeny could be selectively devoid tumorigenic and...
It is believed that adult tissues in mammals lack the plasticity needed to assume new developmental fates because of absence efficient pathways dedifferentiation. However, well-documented ability transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) activate lineage development insulin production following ectopic expression liver suggests a surprising degree residual cells. This study seeks mechanistic explanation for capacity PDX-1 endow cells with characteristics function....
Activation of the pancreatic lineage in liver has been suggested as a potential autologous cell replacement therapy for diabetic patients. Transcription factors-induced liver-to-pancreas reprogramming demonstrated numerous species both vivo and vitro. However, human-derived cells capable acquiring alternate repertoire have never characterized. It is yet unknown whether hepatic-like stem or rather adult give rise to insulin-producing cells. Using an vitro experimental system, we demonstrate...
In recent years, leading organizations in inflammatory bowel disease (IBD) have developed quality measures for the care of adults with Crohn's or ulcerative colitis. We used chart audits to assess impact improvement educational activities on documented adherence Physician Quality Reporting System IBD.Twenty community-based gastroenterologists were recruited participate baseline (n = 200), a series 4 accredited feedback, and follow-up 200). Trained abstractors reviewed randomly selected...
Multiple sclerosis (MS) is a complex, chronic, and often disablingneurological disease. Despite the recent incorporation of new treatmentapproaches early in disease course, care providers still face difficultdecisions as to which therapy will lead optimal outcomes whento initiate or escalate therapies. Such decisions require proper assessmentof relative risks, costs, benefits emerging therapies, wellas addressing challenges with adherence achieve managementand outcomes.At 24th Annual Meeting...
BACKGROUND: Recent publications have proposed revisions to diseaseclassification criteria, new definitions of remission, and guidelines forimplementing treat-to-target strategies for the management patientswith rheumatoid arthritis (RA). Despite developments leading thispractice-changing approach, concept treat target has not yetbeen widely accepted or implemented in managed care. At 24th AnnualMeeting Expo Academy Managed Care Pharmacy (AMCP), heldin San Francisco on April 18, 2012, a...
In the U.S., where prevalence of type 2 diabetes has reached epidemic proportions, many patients with this disease are treated by primary care physicians in community-based systems, including accountable organisations (ACOs). To address gaps quality care, national measures have been established, patient-centered adopted Centers for Medicare and Medicaid Services its Shared Savings Program ACOs. From a perspective, high-quality depends on effective communication between clinicians patients,...
Rationale: National quality improvement initiatives emphasize building partnerships between patients and providers by promoting patient engagement through communication, shared decision-making, self-care skills. Efforts to promote are especially important for people with asthma. To cultivate effective in asthma care, may benefit from understanding each other's values perceptions regarding treatment goals, as well barriers optimal care outcomes.Objectives: We conducted a survey study assess...
In the U.S., suboptimal care quality for patients with chronic obstructive pulmonary disease (COPD) is reflected by high rates of emergency department visits and hospital readmissions, as well excessive costs. Moreover, a substantial proportion COPD do not receive guideline-directed therapies. improvement (QI) programs, these types health problems are commonly addressed through interventions that primarily or exclusively support physicians in aligning their practices guidelines clinical...
Multiple barriers exist for appropriate use of the proprotein convertase subtilisin/kexin type 9 enzyme inhibitors (PCSK9i) in patients with atherosclerotic cardiovascular disease (ASCVD) or familial hypercholesterolemia (FH) inadequately controlled despite standard therapies. Among these barriers, high payer rejection rates and inadequate prior authorization (PA) documentation by providers hinder optimal PCSK9i.
In recent years researchers have reported deficits in the quality of care provided to patients with rheumatoid arthritis (RA), including low rates performance on measures. We sought determine influence a improvement (QI) continuing education program rheumatologists' national measures for RA, along other aligned National Quality Strategy priorities. Performance was assessed through baseline and post-education chart audits. Twenty community-based rheumatologists across United States were...
Background: Delays in biologic or small molecule medication administration are associated with increased adverse events, hospitalization, and surgery inflammatory bowel disease (IBD). We evaluated the impact of a quality improvement (QI) intervention on time to biologics molecules (TABS) IBD. Methods: Data were retrospectively extracted for IBD patients prescribed from convenience sample providers participating an accredited QI educational (baseline cohort). Subsequent intervention, data...
Greene, Laurence PhD; Moreo, Kathleen RN-BC, BSN, BHSA, CCM, Cm, CDMS; Sapir, Tamar Stringer, Katie Salinas, Gregory D. Weeks, Matthew MA Author Information
Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions of the gastrointestinal tract. Although adherence to IBD therapies is associated with improved clinical outcomes, overall poor. Consequently, there a critical need develop interventions that monitor in real time and identify reasons for nonadherence support teams initiating effective interventions. Recently, electronic- web-based platforms have been developed guide A novel remote therapy monitoring (RTM) technology, Tappt...
Recommendations for chronic obstructive pulmonary disease (COPD) diagnosis and management requires symptom exacerbation risk assessment. Adherence to these recommendations appears be limited. We examined the impact of a COPD quality improvement (QI) program in Southeastern United States.From 2017 2018, nine 15 primary care physicians were included our study asked identify 6 7 their patients using maintenance medications with at least 2 office visits past year. A separate group (n=135 165...
Sapir, Tamar PhD; Rusie, Erica PharmD; Carter, Jeffrey D. Greene, Laurence Moreo, Kathleen RN-BC, BSN, BHSA, CCM, Cm, CDMS Author Information
Moreo, Kathleen RN-BC, BSN, BHSA, CCM, Cm, CDMS; Sapir, Tamar PhD; Greene, Laurence PhD Author Information
Purpose/Objectives: This article is intended to update case managers on recent advances in comparative effectiveness research (CER) led by the Agency for Healthcare Research and Quality. The explores potential implications applications of CER findings management practice. Primary Practice Settings: All settings. Findings/Conclusions: An ongoing national movement advance provide health care professionals with answers questions about which diagnostic methods, therapies, devices, services,...
In U.S. internal medicine residency program studies, residents indicated low self-assessed HIV training adequacy, patient care experience, and clinical skills competence. Little is known for infectious disease (ID) fellows, but review findings indicate that increased healthcare provider (HCP) experience are associated with better outcomes. As part of a continuing medical education (CME) on HIV, we conducted survey study in which ID fellows rated their comfort level, care. On October 1, 2016,...