Abstract Background. Over half of new cancer cases occur in patients aged ≥65 years. Many older can benefit from intensive therapies, yet evidence suggests that this population is undertreated. Methods. To assess preferences and influential factors geriatric management, practicing U.S. medical oncologists completed a survey containing four detailed vignettes exploring colon, breast, lung, prostate treatment. Participants were randomly assigned one two surveys with identical except for...

Purpose: Even with the dissemination of several clinical guidelines, chronic obstructive pulmonary disease (COPD) remains underdiagnosed and mismanaged by many primary care physicians (PCPs). The objective this study was to elucidate barriers consistent implementation COPD guidelines. Patients methods: A cross-sectional implemented in July 2008 designed assess attitudes guideline usage. Results: Five hundred US PCPs (309 family medicine physicians, 191 internists) were included analysis....

Kainate receptors have been implicated in excitotoxic neuronal death induced by diseases such as epilepsy and stroke. Actinfilin, a synaptic member of the BTB-Kelch protein family, is known to bind actin cytoskeleton. However, little understood about its function at synapse. Here, we report that actinfilin able GluR6, kainate-type glutamate receptor subunit, target GluR6 for degradation. Like many members acts substrate adaptor, binding Cullin 3 (Cul3) linking E3 ubiquitin-ligase complex. We...

Purpose: Obesity remains a serious public health problem. The purpose of this study was to identify the current attitudes and practices primary care physicians (PCPs) with respect obesity. Methods: A survey systematically developed administered electronically PCPs, who received small honorarium for their time. Results were analyzed specific associations each other demographic variables. Results: Physicians expressed little confidence in ability manage In general, however, they believed that...

Long-acting injectable antipsychotics (LAIs) improve adherence and reduce schizophrenia relapse rates. Data on which LAI attributes drive clinician preference are limited. In the DECIDE survey, 380 psychiatric clinicians (psychiatrists, nurse practitioners, physician assistants) were surveyed regarding preferences when selecting initiating LAIs for patients with schizophrenia. Responses analyzed by use of (high [≥ 31% their using LAIs] or low [≤ 14% LAIs]) mindset toward (early, severity...

Introduction Sleep apnea can have severe negative health effects, including cardiovascular diseases, metabolic disorders, and decreased quality of life. Continuous positive airway pressure (CPAP) therapy is highly effective the gold standard treatment for sleep apnea; however, traditionally fragmented healthcare has resulted in low levels adoption adherence. A recent white paper analysis traditional plan claims found that a comprehensive model significantly outperformed plans with higher...

Long-acting injectable antipsychotics (LAIs) reduce relapses in schizophrenia; however, most clinicians reserve LAIs for nonadherence with oral (OAs) or severe disease. US psychiatric were surveyed regarding their schizophrenia management practices and use of LAIs. Respondents grouped by LAI (high [≥ 31% patients using LAIs], low [≤ 14% LAIs]; mid not analyzed) mindset based on response to "Which the following best fits current way you view your [LAIs] schizophrenia?" (n = 380) distributed...

The amount of medical education offered through the Internet continues to increase, providing unprecedented access for physicians nationwide. However, process evaluating these activities is ongoing. This study a continuation an earlier report that found online continuing (CME) be highly effective in making evidence-based decisions.To determine effectiveness 114 CME activities, case vignette-based surveys were administered U.S.-practicing immediately following participation, and...

In neurons, L-type calcium channels (CaV1.2 and CaV1.3) regulate an extensive range of functions. However, the roles CaV1.3-containing L channels, which are physiologically pharmacologically distinct from better understood CaV1.2 only beginning to be determined. We find that CaV1.3 modulated by insulin-like growth factor-1/receptor tyrosine kinase (IGF-1/RTK) through a signaling pathway involves phospholipase C, release IP₃-sensitive internal stores, calcium/calmodulin II....

The purpose of this study was to evaluate the effectiveness a patient education program developed facilitate statin adherence. A controlled trial designed test multifaceted included brief, in-office physician counseling kit followed by mailings. primary end point adherence filling prescriptions during 120-day period. Patients new statins enrolled and completed survey. Data from national pharmacy claims database were used track therapy exposed achieved 12.4 higher average number prescription...

In response to 5-hydroxytryptamine (5-HT), the type 1 serotonin receptors (5-HT1Rs) preferentially couple inhibitory G protein and elicit many physiological behavioral processes. However, their regulation by intracellular kinases has not been fully investigated. this study, we identified that glycogen synthase kinase-3 (GSK3) differentially regulates 5-HT1Rs. receptor-expressing cells brain slices, activation of both 5-HT1AR 5-HT1BR reduced forskolin-stimulated cAMP production, but only...

Schizophrenia is a chronic and serious mental disorder characterized by disturbances in thought, perception, behavior that impair daily functioning quality of life. Long-acting injectable (LAI) antipsychotic medications may improve long-term outcomes over oral medications; however, LAI are often only considered as last resort late the disease course. This study sought to assess current clinical practice patterns, clinicians' attitudes, barriers use well identify unmet educational needs...

Adult attention-deficit/hyperactivity disorder (ADHD) is a common neuropsychiatric disorder, yet only 1 in 10 affected adults receives treatment. The study objective was to assess gaps knowledge and describe current practice patterns of primary care physicians psychiatrists the United States management adult patients with ADHD.Primary completed an Internet survey as needs assessment customary related ADHD. clinical case vignettes were followed by practice, confidence, barrier questions....

Introduction: Recent information on the preferences and trends of medical sources for US practicing physicians in past several years is lacking. The purpose this study was to identify current format attitudes as well over time provide timely use educational planning. Methods: A survey instrument developed distributed 2013 specialties. Data were aggregated analyzed understand across these physicians. Differences between among demographic subsets physicians, such practice type location,...

Dr. Salinas: Director of Research and Assessment Services, CE Outcomes, LLC. Disclosure: The author reports none. Correspondence: Gregory D. Salinas, 107 Frankfurt Circle, Birmingham, AL 35211; e-mail: [email protected]. • Published online in Wiley Online Library (wileyonlinelibrary.com).

Abstract Background Little is known about patients’ perception of care and management Crohn’s perianal fistulas (CPF). This study was conducted to understand US patient caregiver attitudes challenges CPF care. Methods Patients with caregivers patients completed a 36-question survey their perceptions regarding the diagnosis, treatment, overall CPF. Patients/caregivers were recruited via online fistula support group websites forums gastroenterologists (GEs) surgeons from October 2020 through...

Schizophrenia is a chronic, serious, and disabling mental disorder that affects how an individual thinks, feels, behaves. With the availability of effective antipsychotic medications, care people with schizophrenia has shifted from psychiatric hospitals to outpatient treatment caregivers, including family members. Caregivers are often-overlooked target for education but may be key resource enhance patient foster greater adherence treatment. This study sought examine burdens faced by...

Introduction: Due to the significant and increasing problem of chronic pain in United States, management is a frequent need many healthcare settings. At same time, there has been rising concern with abuse/misuse potential for addiction opioid therapies. This study was conducted better understand professionals’ current knowledge, perceptions, clinical practice patterns regarding prescribing extended-release or long-acting therapy patients pain.Methods: from March 2011 May 2011; it utilized...

Abstract Objective To examine cystic fibrosis (CF) physician adherence to the 2007 CF Foundation (CFF) Pulmonary Guidelines for Chronic Medications. Specifically and barriers prescribing level A medication recommendations (i.e., inhaled tobramycin dornase alfa) B macrolide antibiotics hypertonic saline) were studied. Methods During Spring 2010, CFF emailed survey invitations directors of 136 accredited care centers treating 50+ patients. Directors asked forward their colleagues. One hundred...

Abstract Background Management of short‐bowel syndrome with intestinal failure (SBS‐IF) is complex and requires a multidisciplinary approach. Because the rarity SBS‐IF, healthcare professionals (HCPs) often lack clinical experience disease may benefit from education regarding SBS‐IF its management. This study identified unmet educational needs related to management patients SBS‐IF. Methods was prospective, web‐based survey (December 2019–January 2020) in which series questions were posed US...

With increasing numbers of patients experiencing chronic pain, opioid therapy is becoming more common, leading to increases in concern about issues abuse, diversion, and misuse. Further, the US Food Drug Administration recently released a statement notifying sponsors manufacturers extended-release long-acting opioids need develop Risk Evaluation Mitigation Strategies (REMS) programs order ensure that benefits this choice outweigh potential risks. There little research on physician opinions...

To better understand current practices of U.S.-based physicians in the management Tourette syndrome (TS) and identify gaps that may be addressed by future education. Two survey instruments were developed to gather data on TS perceptions from caregivers children with TS. The clinician was consultation a physician expert utilized clinical vignettes assess quantify practice patterns. caregiver adapted other published studies gathered details diagnosis, treatment, regarding management. Data...