A5008479130- Political Conflict and Governance
- International Relations and Foreign Policy
- International Development and Aid
- Defense, Military, and Policy Studies
- Electoral Systems and Political Participation
- Fiscal Policies and Political Economy
- Advanced biosensing and bioanalysis techniques
- Child and Adolescent Psychosocial and Emotional Development
- Circadian rhythm and melatonin
- Estrogen and related hormone effects
- Peacebuilding and International Security
- Stress Responses and Cortisol
- Inflammatory mediators and NSAID effects
- Parental Involvement in Education
- Advanced Biosensing Techniques and Applications
- Complex Systems and Decision Making
- Biomedical and Engineering Education
- Historical Studies and Socio-cultural Analysis
- Inflammatory Bowel Disease
- Bacteriophages and microbial interactions
- Health Systems, Economic Evaluations, Quality of Life
- Child Welfare and Adoption
- Homelessness and Social Issues
- Adolescent and Pediatric Healthcare
- Fiscal Policy and Economic Growth
University of Houston
2023-2025
Appalachian State University
2020-2023
BorgWarner (United States)
2023
BorgWarner (United Kingdom)
2017-2022
Western University
2021
University of Mississippi
2012-2019
Vanier College
2012-2018
Mahle (United Kingdom)
2018
Eli Lilly (United States)
2017
Atrium Health Wake Forest Baptist
2017
Background The interrogation of proteomes ("proteomics") in a highly multiplexed and efficient manner remains coveted challenging goal biology medicine. Methodology/Principal Findings We present new aptamer-based proteomic technology for biomarker discovery capable simultaneously measuring thousands proteins from small sample volumes (15 µL serum or plasma). Our current assay measures 813 with low limits detection (1 pM median), 7 logs overall dynamic range (∼100 fM–1 µM), 5% median...
Abstract Interrogation of the human proteome in a highly multiplexed and efficient manner remains coveted challenging goal biology. We present new aptamer-based proteomic technology for biomarker discovery capable simultaneously measuring thousands proteins from small sample volumes (15 [mu]L serum or plasma). Our current assay allows us to measure ~800 with very low limits detection (1 pM average), 7 logs overall dynamic range, 5% average coefficient variation. This is enabled by generation...
Six new 5-position modified dUTP derivatives connected by a unique amide linkage were synthesized and tested for compatibility with the enzymatic steps of in vitro selection. commercially available DNA polymerases their ability to efficiently incorporate each these during PCR. It was not possible perform PCR under standard conditions using any studied. In contrast, primer extension reactions random templates, as well defined sequence successful. KOD XL D. Vent found be most efficient at...
In Brief Immunohistochemistry is used in both research and clinical settings to identify proteins tissue samples. Despite the power versatility of immunohistochemistry, limitations are imposed by slow diffusion antibodies through need for secondary staining or signal amplification. Aptamers can circumvent these limitations, but their application has been hindered nonspecific binding cellular components, particularly nucleus. Here we describe unique off-rate modified aptamers that facilitate...
The COVID-19 pandemic both exposed and exacerbated numerous preexisting inequalities faced by marginalized communities in the United States, particularly those that are culturally, economically, linguistically diverse. Among many unique challenges posed pandemic, there is still limited understanding of how diverse families, including Latinx managed abrupt transition to remote schooling for their children. This qualitative study explored experiences perceptions rural mothers who suddenly...
Democracy has been the primary focus of our efforts to understand impact domestic institutions on processes international conflict. In this article, we examine how a particular nondemocratic regime type, postrevolutionary states, affects military capabilities and war outcomes. Drawing scholarship that conceptualizes revolutions as unique class modernizing events result in stronger state structures, argue states should be better able mobilize populations economic resources for purposes. Tests...
International relations researchers study the interactions of states in international system. Excluded from almost all such analyses is any consideration how those became members system first place. State making researchers, contrast, focus on formation experiences states. Drawing insights both approaches, we argue that with positive birth legacies should be more successful at state and achieve favorable outcomes than without legacies. As fighting winning wars are a common pathway to...
Abstract The case of an elderly patient with mild dementia and severe depression is reviewed including analysis the barriers to successful transition that led readmission. Situations likely result in failed transitions include poor social support, discharge during times when ancillary services are unavailable, uncertain medication reconciliation, depression, patients' cognitive limitations. Evidence suggests deficits communication by hospital physicians primary care providers occur commonly...
How and why do regime type interstate war affect government spending? We argue that a political leader allocates scarce resources between social military expenditures as function of their relative efficiency in securing her survival. derive four hypotheses concerning how mobilization for demobilization from affects spending differently democratic autocratic regimes. Compared to democracies, autocracies should increase greater degree during wartime decrease extent following war. Autocracies...
Recent research concludes fighting or losing an interstate war is not costlier for democratic leaders than dictators, which implies most of our institutional explanations differences in conflict behavior across regime type rest on empirically tenuous assumptions. I argue military mobilization, a fundamental but often overlooked aspect war, should be democrats dictators. Waging associated with higher spending and, often, lower social spending. Variation the representation general public,...
Realisation of electrically boosted turbochargers requires electric motors capable operating at very high speeds. These often use a permanent magnet rotor with the magnets retained within an interference fit external sleeve. Whilst it is possible to model such systems numerically, these models are inefficient tool for design optimisation. Current analytical rotors typically consider stresses induced by shrink sleeve separately from generated centripetal forces due rotation. However, approach...
Abstract Political leaders’ willingness to use force is central many explanations of foreign policy and interstate conflict. Unfortunately, existing indicators typically measure one aspect this general concept, have limited coverage, and/or are not derived independently participation in conflicts. We develop a strategy for constructing measures underlying with data on their background experiences, political orientations, psychological traits Bayesian latent variable framework. Our approach...
We argue patterns of state failure are influenced by variation in how states emerged as independent political actors. In particular, with positive birth legacies, those whose emergence required relatively high levels capacity and legitimacy, should be less likely to experience than countries that experienced auspicious births. assess this claim on the universe international system between 1950 2002 multistate duration models estimate probabilities transition into out periods failure. find...
Drawing on the idea that electoral accountability is a source for peace, recent scholarship claims term limits result in democratic leaders who are systematically more likely to initiate conflicts. We consider broader set of theoretical arguments allow possibility leaders' preferences and strategic environment condition relationship between interstate conflict. These suggest multiple hypothetical relationships conflict, some which conditional hawkish or dovish nature leader's preferences....
The literature on the legacies of communism for democratization has focused almost exclusively explaining variation in democratic experiences within postcommunist space. While this is useful many ways, it says little about a communist legacy comparison to other types antecedent regimes. We take different approach, looking at question by comparing those states through prism survival. One key implication shift perspective that survival highlights range social and economic factors are likely...
The human patient simulators that are currently used in multidisciplinary operating room team training scenarios cannot simulate surgical tasks because they lack a realistic anatomy. Thus, eliminate the surgeon's primary task room. trainee is presented with significant barrier when he or she attempts to suspend disbelief and engage scenario.To develop test simulation-based strategy challenges communication abilities teamwork competencies of surgeons while engaged operative maneuvers.This...
How does increasing military spending affect social and economic growth? We argue leaders vary in their preferences over how to pay for failing account interdependence among methods of government finance, spending, performance limits scholars’ ability identify the consequences spending. use vector autoregressive models estimate relationships growth, tax revenue, debt, money supply United States between 1947 2007. find that has a nonlinear effect on growth varies time existence...
Edited by Lars Bo Kaspersen and Jeppe StrandsbjergCambridge University Press, 2017Charles Tilly’s research on the formation development of states continues to shape trajectory countless ...