A5002167965- Cardiovascular Function and Risk Factors
- High Altitude and Hypoxia
- Immune Response and Inflammation
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Anesthesia and Sedative Agents
- Gut microbiota and health
- Nitric Oxide and Endothelin Effects
- Cardiac Imaging and Diagnostics
- Inflammatory Bowel Disease
- Pharmacogenetics and Drug Metabolism
- Cancer therapeutics and mechanisms
- Cardiovascular Disease and Adiposity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Anesthesia and Neurotoxicity Research
- Eicosanoids and Hypertension Pharmacology
- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Advanced MRI Techniques and Applications
- Respiratory Support and Mechanisms
- Lymphoma Diagnosis and Treatment
Shanghai Children's Medical Center
2016-2025
Shanghai Jiao Tong University
2016-2025
Institute of Microbiology
2025
Chinese Academy of Sciences
2025
Qinghai University
2010-2024
Nanjing Medical University
2015-2024
Guangzhou Medical University
2024
First Affiliated Hospital of Xinjiang Medical University
2019-2024
Xuzhou Medical College
2009-2024
Xinjiang Medical University
2019-2024
Recent studies have established the involvement of fat mass and obesity-associated gene (FTO) in metabolic disorders such as obesity diabetes. However, precise molecular mechanism by which FTO regulates metabolism remains unknown. Here, we used a structure-based virtual screening U.S. Food Drug Administration-approved drugs to identify entacapone potential inhibitor. Using structural biochemical studies, showed that directly bound inhibited activity vitro. Furthermore, administration reduced...
Aims: Combined hepatocellular cholangiocarcinoma (CHC) is a rare form of primary liver cancer, showing mixture and biliary features. Data suggest that most CHC arise from hepatic progenitor cells (HPCs). The aim was to investigate the origin CHC. Methods results: Twelve cases were studied by immunohistochemistry for hepatocytic (hepPar1, α‐fetoprotein), cholangiocytic cytokeratin [(CK) 7, CK19], cell (OV‐6), haematopoietic stem (c‐kit, CD34), as well CD45 chromogranin‐A markers. combination...
Cine balanced steady-state free precession (SSFP), the preferred sequence for ventricular function, demands uninterrupted radio frequency (RF) excitation to maintain during suspended respiration. This is difficult accomplish in sedated children. In this work, we validate a respiratory triggered (RT) SSFP that drives magnetization before commencing retrospectively cardiac gated cine acquisition pediatric population. prospective study was performed on 20 children with congenital heart disease...
This experiment was conducted to investigate the effect of exposure high altitude and low oxygen on intestinal microbial communities using mice as an animal model. Fecal microbiota from housed in a control environment representing 2,200 meters (NC group) above sea level with 16% Oxygen that were placed hypobaric chamber 5000 (HC 11% for 30 days, analyzed by HiSeq Illumina sequencing platform. The results showed significant difference beta diversity observed between two groups, while no alpha...
<h3>Importance</h3> The Mobile Health Technology for Improved Screening and Optimized Integrated Care in Atrial Fibrillation (mAFA-II) trial is a prospective cluster randomized that found significant reduction the composite clinical outcome of stroke or thromboembolism, all-cause death, rehospitalization among patients with atrial fibrillation (AF) who used mobile health (mHealth) technology implemented Better (ABC) pathway (ie, A, anticoagulation/avoid stroke; B, better symptom control; C,...
Background : Exclusive enteral nutrition (EEN) is an effective and safe remission induction treatment for Crohn's disease in adults. Its influence on adults’ health‐related quality of life remains unknown. The aim this study was to determine the effect EEN adults with active disease. Materials Methods Patients recruited were treated a polymeric feed that taken orally daytime via self‐intubated nasogastric tube at night 4 weeks. Prospective evaluation activity (Crohn's Disease Activity Index,...
A supramolecular hydrogel was prepared to encapsulate and release both camptothecin doxorubicin in a controlled manner for sustainedly synergistic tumor therapy.
To differentiate pre-invasive lesion from invasive pulmonary adenocarcinoma (IPA) appearing as ground-glass nodules (GGNs) using CT features.149 GGNs were enrolled in this study, with 74 pure (p-GGNs) and 75 mixed (m-GGNs). Firstly, univariate analysis was used to analyse the difference of features between IPA. Then, multivariate conducted identify variables that could independently Receiver operating characteristic curve performed evaluate differentiating value identified variables.In...
The tissue engineering of cartilage represents a promising approach for repair, and the process includes cells, growth factors, scaffold. scaffold is important supporting, reinforcing, organizing regenerating tissue. Currently, Wharton's jelly (WJ) considered an ideal material because it has similar composition, structure, function as Here, we fabricated electrospun nanofibers composed decellularized WJ matrix reinforced by poly(ε-caprolactone) (PCL) investigated feasibility nanofibrous...
Summary Background Cardiovascular disease (CVD) was in common coronavirus 2019 (COVID-19) patients and associated with unfavorable outcomes. We aimed to compare the clinical observations outcomes of severe acute respiratory syndrome 2 (SARS-CoV-2)-infected or without CVD. Methods Patients laboratory-confirmed SARS-CoV-2 infection were clinically evaluated at Wuhan Seventh People’s Hospital, Wuhan, China, from 23 January 14 March 2020. Demographic data, laboratory findings, comorbidities,...
The aim of this study was to investigate the effect Arginase I (ArgI) on plaque stabilization in unruptured atherosclerotic and explore its mechanism. model established New Zealand rabbits by balloon injury abdominal arteries a high cholesterol (1%) diet. overexpression reduced content macrophages lipids increased that smooth muscle cells collagen plaque, thus contributing decreased vulnerability. expression inflammatory cytokines tumour necrosis factor-α (TNF-α) interleukin-6 (IL-6) as well...