A5007434317- Reproductive Biology and Fertility
- Ovarian function and disorders
- 3D Printing in Biomedical Research
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Reproductive Health and Technologies
- Birth, Development, and Health
- Hypothalamic control of reproductive hormones
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cancer Risks and Factors
- Regulation of Appetite and Obesity
- Reproductive System and Pregnancy
- Consumer Attitudes and Food Labeling
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Uterine Myomas and Treatments
- Pregnancy and preeclampsia studies
- Food Waste Reduction and Sustainability
- Cell Image Analysis Techniques
- Renal and related cancers
- COVID-19 Impact on Reproduction
- Mesenchymal stem cell research
- Demographic Trends and Gender Preferences
Augusta University
2018-2021
Augusta University Health
2018-2019
Wayne State University
2015-2018
Detroit Medical Center
2015
Washington University in St. Louis
2008-2014
Johns Hopkins University
2009
Johns Hopkins Bayview Medical Center
2009
Associations between maternal obesity and adverse fetal outcomes are well documented, but the mechanisms involved largely unknown. Most previous work has focused on postconceptional events, however, our laboratory shown pre- periconceptional aberrations in glucose metabolism have effects oocytes embryos that carry to fetus. To demonstrate of periods, we compared reproductive tissues from diet-induced obese female mice those control mice. Ovaries were either stained for follicular apoptosis...
Free fatty acids (FFAs) are energy substrates for many cell types, but in excess, some FFAs can accumulate nonadipose cells, inducing apoptosis. Also known as lipotoxicity, this phenomenon may play a role the development of obesity-related disease. Obesity is common among reproductive age women and associated with adverse pregnancy fetal outcomes; however, little about effects excess on embryos subsequent development. To address knowledge gap, murine blastocysts were cultured palmitic acid...
BACKGROUNDAdiponectin (Adipoq), a protein secreted by adipocytes in inverse proportion to the adipose mass present, modulates energy homeostasis and increases insulin sensitivity. Tissue Adipoq signaling decreases settings of maternal diabetes, polycystic ovary syndrome (PCOS) endometriosis, conditions which are associated with reproductive difficulty. Our objective was define expression hormonal regulation its receptors mouse preimplantation embryo uterus.
Maternal insulin resistance results in poor pregnancy outcomes. In vivo and vitro exposure of the murine blastocyst to high or IGF1 down-regulation receptor (IGF1R). This turn leads decreased glucose uptake, increased apoptosis, as well resorption growth restriction. Recent studies have shown that activation AMP-activated protein kinase (AMPK) reverses these detrimental effects; however, mechanism was not clear. The objective this study determine how AMPK rescues insulin-resistant...
Obese women experience worse reproductive outcomes than normal weight women, specifically infertility, pregnancy loss, fetal malformations and developmental delay of offspring. The aim the present study was to use a genetic mouse model obesity recapitulate human phenotype further examine potential mechanisms therapies. New inbred, polygenic Type 2 diabetic TallyHO mice age-matched control C57BL/6 were superovulated obtain morula or blastocyst stage embryos that cultured in tubal fluid (HTF)...
Mouse Embryonic Stem Cells (mESCs) are unique in their self-renewal and pluripotency. Hypothetically, mESCs model gestational stress effects or stresses of vitro fertilization/assisted reproductive technologies drug/environmental exposures that endanger embryos. Testing responses should diminish expedite vivo embryo screening. Transgenic for green fluorescent protein (GFP) reporters differentiation use the promoter platelet-derived growth factor receptor (Pdgfr)a driving GFP expression to...
Genetic approaches in humans with gonadotropin releasing hormone (GnRH) deficiency causing hypogonadotropic hypogonadism (HH) have been important to understand normal reproduction. NSMF (NMDA receptor synaptonuclear signaling & neuronal migration factor), formerly known as NELF (nasal embryonic LHRH gene mutations identified normosmic HH (nHH) and Kallmann syndrome (KS). The Nsmf knockout mouse (KO) females puberty, but also manifest subfertility of uncertain etiology. Although many...
To study if a pituitary or ovarian defect contributes to subfertility of the female Nsmf knockout (KO) mouse, an animal model hypogonadotropic hypogonadism gene NSMF.