A5102738809- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Antibiotic Use and Resistance
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- bioluminescence and chemiluminescence research
- Nosocomial Infections in ICU
- Antibiotics Pharmacokinetics and Efficacy
- Erythrocyte Function and Pathophysiology
- Click Chemistry and Applications
- Chronic Myeloid Leukemia Treatments
- Blood properties and coagulation
- Retinal Diseases and Treatments
- COVID-19 Clinical Research Studies
- Retinal Development and Disorders
- Pancreatitis Pathology and Treatment
- Adenosine and Purinergic Signaling
- Epigenetics and DNA Methylation
- Signaling Pathways in Disease
- 14-3-3 protein interactions
- MicroRNA in disease regulation
- Immune cells in cancer
Washington University in St. Louis
2024
University of Virginia
2021-2023
Partners In Care
2017-2020
University of Maryland, Baltimore
2012
MicroRNAs (miRs) play major roles in normal hematopoietic differentiation and malignancies. In this work, we report that miR-27a, its coordinately expressed cluster (miR-23a∼miR-27a∼miR-24-2), was down-regulated acute leukemia cell lines primary samples compared to stem-progenitor cells (HSPCs). Decreased miR-23a expression some mediated by c-MYC. Replacement of miR-27a inhibited growth due, at least part, increased cellular apoptosis. We identified a member the anti-apoptotic 14-3-3 family...
Objectives: To use a standardized tool for multicenter assessment of antibiotic appropriateness in ICUs and identify local stewardship improvement opportunities. Design: Pilot point prevalence conducted on October 5, 2016; survey March 1, 2017. Setting: 12 U.S. acute care hospitals with median bed size 563. Patients: Receiving antibiotics participating units Interventions: The Centers Disease Control Prevention the Assessment Appropriateness Inpatient Antibiotics was made actionable by an...
<p>FIGURE S2. Luciferase activity for LIG3 and PARP1 promoterless controls in Mo7e-BCR-ABL 32D-FLT3/ITD Cells; Relative luciferase 293T cells transfected with c-MYC expression contruct (pcDNA3-c-myc) control vector (pcDNA3)</p>
<p>FIGURE S1. SiRNA depletion of c-myc in MO7e-BCR/ABL cells studied for viability</p>
<p>FIGURE S2. Luciferase activity for LIG3 and PARP1 promoterless controls in Mo7e-BCR-ABL 32D-FLT3/ITD Cells; Relative luciferase 293T cells transfected with c-MYC expression contruct (pcDNA3-c-myc) control vector (pcDNA3)</p>
<p>FIGURE S1. SiRNA depletion of c-myc in MO7e-BCR/ABL cells studied for viability</p>
A national assessment of antibiotic appropriateness in intensive care units (ICUs) with benchmarking was performed to assist stewardship programs (ASPs) identify improvement opportunities. Centers for Disease Control and Prevention tool adapted by an expert panel from the Partnership Quality Care (PQC), a coalition dedicated high quality US hospitals, validate appropriate use measurement via point prevalence survey on single day. Data were collected ASP personnel at each hospital,...