A5010510821- Pediatric Hepatobiliary Diseases and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic and Kidney Cyst Diseases
- Biomedical Research and Pathophysiology
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Zebrafish Biomedical Research Applications
- Cerebral Palsy and Movement Disorders
- Cystic Fibrosis Research Advances
- Endoplasmic Reticulum Stress and Disease
- Adenosine and Purinergic Signaling
- Assistive Technology in Communication and Mobility
- Microtubule and mitosis dynamics
- Stroke Rehabilitation and Recovery
- Liver physiology and pathology
- Peroxisome Proliferator-Activated Receptors
- Infant Development and Preterm Care
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Nuclear Structure and Function
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Sphingolipid Metabolism and Signaling
- Neurogenesis and neuroplasticity mechanisms
University of Zurich
2019-2024
Vollum Institute
2022
Oregon Health & Science University
2022
University of Genoa
2021
European Molecular Biology Laboratory
2019
Heidelberg University
2019
Yale University
2015-2016
Cystic fibrosis–associated liver disease is a chronic cholangiopathy that negatively affects the quality of life cystic fibrosis patients. In addition to reducing biliary chloride and bicarbonate secretion, up‐regulation toll‐like receptor 4/nuclear factor kappa light‐chain‐enhancer activated B cells (NF‐κB)–dependent immune mechanisms plays major role in pathogenesis may represent therapeutic target. Nuclear receptors are transcription factors regulate several intracellular functions. Some...
In the liver, cystic fibrosis (CF) transmembrane conductance regulator (CFTR) regulates bile secretion and other functions at apical membrane of biliary epithelial cells (i.e., cholangiocytes). CF‐related liver disease is a major cause death in patients with CF. CFTR dysfunction affects innate immune pathways, generating para‐inflammatory status epithelia. This study investigates mechanisms linking to toll‐like receptor 4 activity. We found that associated multiprotein complex normal mouse...
During brain development, many newborn neurons undergo apoptosis and are engulfed by microglia, the tissue-resident phagocytes of brain, in a process known as efferocytosis. A hallmark microglia is their highly branched morphology characterized presence numerous dynamic extensions that these cells use for scanning parenchyma engulfing unwanted material. The mechanisms driving branch formation apoptotic cell engulfment unclear. By taking live-imaging approach zebrafish, we show while generate...
Polycystin‐2 (PC2 or TRPPC2), a member of the transient receptor potential channel family, is nonselective calcium channel. Mutations in PC2 are associated with polycystic liver diseases. PC2‐defective cholangiocytes show increased production cyclic adenosine monophosphate, protein kinase A–dependent activation extracellular signal–regulated 1/2 (ERK1/2) pathway, hypoxia‐inducible factor 1α (HIF‐1α)–mediated vascular endothelial growth (VEGF) production, and stimulation cyst progression....
Microglia play important roles in brain development and homeostasis by removing dying neurons through efferocytosis. Morphological changes microglia are hallmarks of many neurodegenerative conditions, such as Niemann-Pick disease type C. Here, NPC1 loss causes to shift from a branched an ameboid form, though the cellular basis functional impact this change remain unclear. Using zebrafish, we show that deficiency efferocytosis-dependent expansion microglial gastrosome, collection point for...
Abstract During brain development, many newborn neurons undergo apoptosis and are engulfed by microglia, the tissue-resident phagocytes of brain, in a process known as efferocytosis. A hallmark microglia is their highly branched morphology characterised presence numerous dynamic extensions that these cells use for scanning parenchyma engulfing unwanted material. The mechanisms driving branch formation apoptotic cell engulfment unclear. By taking live imaging approach zebrafish, we show while...