A5101605392- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Cervical Cancer and HPV Research
- Vaccine Coverage and Hesitancy
- RNA modifications and cancer
- Cancer-related gene regulation
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- IoT and Edge/Fog Computing
- Hepatitis B Virus Studies
- Advanced Data and IoT Technologies
- Complement system in diseases
- Cancer-related molecular mechanisms research
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- Pharmacological Effects and Toxicity Studies
- Advanced Computational Techniques and Applications
- Urticaria and Related Conditions
First Affiliated Hospital of Guangzhou Medical University
2021-2025
State Key Laboratory of Respiratory Disease
2021-2025
Guangzhou Medical University
2021-2025
Takeda (United States)
2024-2025
Nanjing University of Chinese Medicine
2025
Longgang Central Hospital
2023-2025
Southern Medical University
2015-2025
Zhujiang Hospital
2025
National Clinical Research
2025
Sorbonne Université
2024
Congenital thrombotic thrombocytopenic purpura (TTP) results from severe hereditary deficiency of ADAMTS13. The efficacy and safety recombinant ADAMTS13 standard therapy (plasma-derived products) administered as routine prophylaxis or on-demand treatment in patients with congenital TTP is not known.
G-quadruplex formation in genomic DNA is considered to regulate transcription. Previous investigations almost exclusively focused on intramolecular G-quadruplexes formed by carrying four or more G-tracts, and structure has rarely been studied physiologically relevant processes. Here, we report an entirely neglected, but actually much prevalent form of G-quadruplexes, DNA:RNA hybrid (HQ) that forms HQ requires as few two G-tracts instead a non-template strand. Potential sequences (PHQS) are...
Background: Human Papillomavirus (HPV) infection can lead to serious health issues and remains the most common sexually transmitted infection.Despite availability of effective vaccines, HPV vaccination rates are suboptimal.Methods: In a cluster randomized trial, an intervention targeting parents adolescents (11-17 years) eligible for dose vaccine was tested in pediatric clinics part urban system.Parents watched digital video outlining risks benefits using tablet exam room.The primary outcome...
We recently reported that a DNA:RNA hybrid G-quadruplex (HQ) forms during transcription of DNA bears two or more tandem guanine tracts (G-tract) on the nontemplate strand. Putative HQ-forming sequences are enriched in nearby 1000 nt region right downstream start sites strand warm-blooded animals, and HQ regulates under both vitro vivo conditions. Therefore, knowledge mechanism formation is important for understanding biological function as well manipulating gene expression by targeting HQ....
Abstract RNA N 6 -methyladenosine (m A), the most abundant internal modification of mRNAs, plays key roles in human development and health. Post-translational methylation proteins is often critical for dynamic regulation enzymatic activity. However, role core methyltransferase METTL3/METTL14 m A remains elusive. We find by mass spectrometry that METTL14 arginine 255 (R255) methylated (R255me). Global mRNA levels are greatly decreased R255K mutant mouse embryonic stem cells (mESCs). further...
Abstract Background: Preserved ratio impaired spirometry (PRISm) refers to decreased forced expiratory volume in 1 s (FEV ) the setting of preserved ratio. Little is known about role PRISm and its complex relation with small airway dysfunction (SAD) lung volume. Therefore, we aimed investigate associations between SAD Methods: We conducted a cross-sectional community-dwelling study China. Demographic data, standard respiratory epidemiology questionnaire, spirometry, impulse oscillometry...
Background During aging, chronic inflammation can promote tumor development and metastasis. Patients with inflammatory bowel diseases (IBD) are at an increased risk of developing colorectal cancer (CRC). However, the molecular mechanism underlying is still unclear. Methods We conducted a large-scale single-cell sequencing analysis comprising 432,314 single cells from 92 CRC 24 IBD patients. The focused on heterogeneity commonality respect to immune cell landscape, cellular communication,...
Recently, we reported the co-transcriptional formation of DNA:RNA hybrid G-quadruplex (HQ) structure by non-template DNA strand and nascent RNA transcript, which in turn modulates transcription under both vitro vivo conditions. Here present bioinformatic analysis on putative HQ-forming sequences (PHQS) genomes eukaryotic organisms. Starting from amphibian, PHQS motifs are concentrated immediate 1000-nt region downstream start sites, implying their potential role regulation. Moreover,...
Human mitochondrial DNA contains a distinctive guanine-rich motif denoted conserved sequence block II (CSB II) that stops RNA transcription, producing prematurely terminated transcripts to prime replication. Recently, we reported general phenomenon DNA:RNA hybrid G-quadruplexes (HQs) readily form during transcription when the non-template strand is and such HQs in turn regulate transcription. In this work, show of leads formation stable HQ or alternatively an unstable intramolecular...
Many men who have sex with (MSM) do not disclose their same behaviors to healthcare providers (HCPs). We used a series of logistic regression models explore conceptual framework that first identified predictors disclosure HCPs among young MSM (YMSM), and subsequently examined men's male-male sexual as mediator between sociodemographic behavioral factors three distinct health outcomes [HIV testing, sexually transmitted infection (STI) human papillomavirus (HPV) vaccination]. determined the...
In recent decades, remote sensing object counting has attracted increasing attention from academia and industry due to its potential benefits in urban traffic, public safety, road planning. However, this issue is becoming a challenge for computer vision because of various technical barriers, such as large-scale variation, complex background interference, nonuniform density distribution. Recent results show hopeful prospects using convolutional neural networks (CNNs), but most existing...
Toxic heavy metals have been considered to be harmful environmental contaminations. The molecular mechanisms of heavy-metals-induced cytotoxicity and carcinogenicity are still not well elucidated. Previous reports showed exposures toxic can cause a change DNA cytosine methylation (5-methylcytosine, 5-mC). However, it is clear whether effects on the recently identified new epigenetic marks in both RNA, i.e., 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-foC), 5-carboxylcytosine...
N6-methyladenosine (m6A) has been identified in various biological processes and plays important regulatory functions diverse cells. However, there is still no visualization database for exploring global m6A patterns across cell lines. Here we collected all available MeRIP-Seq m6A-CLIP-Seq datasets from public databases 340,950 179,201 peaks dependent on 23 human eight mouse lines respectively. Those were further classified into mRNA lncRNA groups. To better understand the potential function...
Background and objective: Spirometry is commonly used to assess small airway dysfunction (SAD). Impulse oscillometry (IOS) can complement spirometry. However, discordant spirometry IOS in the diagnosis of SAD were not uncommon. We examined association between within a large cohort subjects identify variables that may explain findings. Methods: 1,836 from ECOPD underwent questionnaires, symptom scores, spirometry, IOS, 1,318 by CT. assessed with R5-R20 > upper limit normal (ULN) two three...
The role of airway impairment assessed by impulse oscillometry (IOS) in patients with chronic obstructive pulmonary disease (COPD) remains unclear. Therefore, this study aimed to analyze the proportion and clinical characteristics IOS across COPD severities, explore whether is a subtype COPD.This was based on cross-sectional data from ECOPD cohort Guangdong, China. Subjects were consecutively recruited July 2019 August 2021. They filled out questionnaires underwent lung function tests,...