A5000377164- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- Phytochemicals and Antioxidant Activities
- Alkaloids: synthesis and pharmacology
- Ginseng Biological Effects and Applications
- Tea Polyphenols and Effects
- Cholesterol and Lipid Metabolism
- Neurological Disease Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
China Medical University
2022-2023
Background. Alzheimer’s disease places a heavy economic burden to healthcare systems around the world. However, effective treatments are still lacking. Traditional Chinese medicines (TCM) of Schisandra chinensis and Acorus tatarinowii Schott have pharmacological effects sedation neuroprotection been clinically proven be in treatment AD. their main anti-Alzheimer’s compounds functional mechanisms remain unclear. Purpose. To elucidate therapeutic components possible Sc-At AD using...
Baihe-Dihuang Tang is a commonly prescribed remedy for depression. In this study, component screening with untargeted and targeted metabolomics was used to identify potential biomarkers depression in chronic unpredictable mildly stressed rats. Using novel identification method, the of organic acids, lily saponins, iridoids, other ingredients formed basis subsequent research. supplementation mild-stress-induced models, increased their body weight, sucrose preference, brain-derived...
Alzheimer's disease (AD), a type of neurodegeneration disease, is characterized by Aβ deposition and tangles nerve fibers. Schisandrin one the main components Fructus Schisandrae Chinensis. Researches showed that schisandrin can improve cognitive impairment memory AD mice, but specific mechanism has not been fully elucidated.The purpose this study to investigate possible in improving pathology.The Morris water maze test was executed detect spatial learning memory. Ultra performance liquid...
Traditional Chinese medicine targeted at gut microbiota has good effects in relieving the clinical manifestation of Alzheimer's disease, and intestinal metabolites are considered as a bridge communication between brain-gut axis. In order to explore molecular mechanism Ganmaidazao decoction treatment, first, model rats induced by Aβ25-35 d-gal were used test therapy extract using Morris Water Maze, Western Blot Elisa. Then 16S rDNA gene sequencing well UPLC-QTOF/MS-based metabolomic analysis...
Schisandrin is one of the main active compounds isolated from fruit Schisandrae chinensis Fructus, which scientifically proven to have beneficial effects on Alzheimer’s disease (AD) treatment at cellular and whole organism level. However, oral availability schisandrin very low, thus implying that underlying mechanism therapeutic effect AD yet be clarified fully. Therefore, we speculated mainly by regulating imbalance gut microbiota (GM). In this study, behavioral experiments H&E...
Alzheimer's disease (AD) is a latent and progressive neurodegenerative disease. Schisandra chinensis(Turcz.)Baill - Acorus tatarinowii Schott (Sc-At) are effective in treating neurological disorders. Purpose of this study to explore the mechanism Sc-At AD treatment. First, untargeted ultra-performance liquid chromatography quadrupole-time flight/mass spectrometer (UPLC-QTOF/MS) metabolomics was employed detect rat brain metabolism. Then, network pharmacology used determine potential anti-AD...
Alzheimer's disease is the most common form of dementia and affects human health. In this study, a classic prescription Chinese Medicine Gan-Mai-Da-Zao decoction was used for treating first time. Hence, firstly components in plasma were screened using UPLC-QTOF/MS. Then MWM, HE Metabolomics methods to examine effect on rats. The results showed 9 active ESI+ 3 ESI− blood identified, improved learning memory ability pathological damage 57 metabolites 21 urine returned normal model group after...