A5009888820- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pediatric health and respiratory diseases
- Pulmonary Hypertension Research and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Inhalation and Respiratory Drug Delivery
- Obstructive Sleep Apnea Research
- Injury Epidemiology and Prevention
- Air Quality and Health Impacts
- Cardiovascular Health and Disease Prevention
- Phosphodiesterase function and regulation
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Gout, Hyperuricemia, Uric Acid
- Ophthalmology and Visual Impairment Studies
- Climate Change and Health Impacts
- Corneal surgery and disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- School Health and Nursing Education
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
First Affiliated Hospital of Guangzhou Medical University
2021-2025
State Key Laboratory of Respiratory Disease
2021-2025
Guangzhou Medical University
2021-2025
He Eye Hospital
2024
Abstract Background: Preserved ratio impaired spirometry (PRISm) refers to decreased forced expiratory volume in 1 s (FEV ) the setting of preserved ratio. Little is known about role PRISm and its complex relation with small airway dysfunction (SAD) lung volume. Therefore, we aimed investigate associations between SAD Methods: We conducted a cross-sectional community-dwelling study China. Demographic data, standard respiratory epidemiology questionnaire, spirometry, impulse oscillometry...
Background and objective: Spirometry is commonly used to assess small airway dysfunction (SAD). Impulse oscillometry (IOS) can complement spirometry. However, discordant spirometry IOS in the diagnosis of SAD were not uncommon. We examined association between within a large cohort subjects identify variables that may explain findings. Methods: 1,836 from ECOPD underwent questionnaires, symptom scores, spirometry, IOS, 1,318 by CT. assessed with R5-R20 > upper limit normal (ULN) two three...
The role of airway impairment assessed by impulse oscillometry (IOS) in patients with chronic obstructive pulmonary disease (COPD) remains unclear. Therefore, this study aimed to analyze the proportion and clinical characteristics IOS across COPD severities, explore whether is a subtype COPD.This was based on cross-sectional data from ECOPD cohort Guangdong, China. Subjects were consecutively recruited July 2019 August 2021. They filled out questionnaires underwent lung function tests,...
The relationship between long-term ozone (O₃) exposure and readmission for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) remains elusive. In this study, we collected individual-level information on AECOPD hospitalizations from a standardized electronic database in Guangzhou January 1, 2014, to December 31, 2015. We calculated the annual mean O₃ concentration prior dates index hospitalization using patients' residential addresses. Employing Cox proportional hazards...
The previous findings on the correlation between spirometry and high-density lipoprotein (HDL) cholesterol are intriguing yet conflicting. aim of this research is to evaluate relationship HDL levels as well imaging parameters in patients with chronic obstructive pulmonary disease (COPD) China.
Studies on consistency among spirometry, impulse oscillometry (IOS), and histology for detecting small airway dysfunction (SAD) remain scarce. Considering invasiveness of lung histopathology, we aimed to compare spirometry IOS with chest computed tomography (CT) SAD detection, evaluate clinical characteristics subjects assessed by these three techniques. We collected baseline data from the Early COPD (ECOPD) study. CT-defined was defined as parametric response mapping quantifying (PRMfSAD) ≥...
Abstract Purpose: To evaluate how intraocular lens (IOL) positioning affects visual quality in patients with high myopia after cataract surgery. Methods: This prospective, randomized study was conducted on 50 eyes from (axial length [AL] >26 mm) or super-high (AL >30 who underwent surgery between October 2022 and 2023. We assessed the IOL position using optical coherence tomography measured higher-order aberrations (HOAs) iTrace system. Correlations markers were then examined. Results:...
Small airway dysfunction (SAD) is common but little known about the longitudinal prognosis of spirometry-defined SAD. Therefore, we aimed to evaluate risk lung function decline and incident chronic obstructive pulmonary disease (COPD) It was a population-based prospective cohort study conducted in Guangdong, China. Participants were enrolled years 2002, 2008, 2012, 2017, 2019, those who completed baseline demographic data, standardized epidemiological questionnaire for COPD, spirometry...
PRISm is regarded as a COPD precursor, but whether this varies by smoking status remains unclear. Are annual lung function decline and the risk of developing airflow limitation different among subtypes status? 2850 participants from 15-year population-based prospective cohort were included in analysis. Participants categorized into three groups: never smokers with normal spirometry (normal control), (NS-PRISm), ever (ES-PRISm). We compared groups. control group exhibited faster function,...
Preserved ratio impaired spirometry (PRISm), which identifies a population at high risk for COPD, has drawn increasing attention. However, definitions PRISm vary across studies, and researches comparing these are limited. We aim to assess the agreement, clinical features, prevalence of defined by restrictive spirometric pattern (RSP) method [that is forced vital capacity (FVC) method] versus expiratory volume in first second (FEV1) fixed values lower limit normal (LLN). All 1862 participants...
Background: High blood eosinophil count (BEC) is a useful biomarker for guiding inhaled corticosteroid therapy in patients with chronic obstructive pulmonary disease (COPD), yet its implications community setting remain underexplored. This study aimed to elucidate the clinical characteristics and outcomes of COPD high BEC within Chinese community. Methods: We obtained baseline 2-year follow-up data from (post-bronchodilator forced expiratory volume 1 second/forced vital capacity <0.70) Early...
Abstract Background The lack of simple and affordable spirometry has led to the missed delayed diagnoses chronic respiratory diseases in communities. PUS201P is a portable developed solve this problem. Objective We aimed verify consistency spirometer with conventional Jaeger spirometer. Methods In cross-sectional study, we randomly recruited 202 subjects aged > 40 years. Testing were performed on all participants. compared forced expiratory volume one second (FEV 1 ), vital capacity...
The inter-relationships among neutrophilic airway inflammation, air trapping and future exacerbation in chronic obstructive pulmonary disease (COPD) remain unclear.To evaluate the associations between sputum neutrophil proportions COPD to determine whether these are modified by significant trapping.Participants with completed data were included followed up first year Early Chronic Obstructive Pulmonary Disease study (n=582). Sputum high-resolution CT-related markers measured at baseline....
The relationship between airway inflammation in chronic obstructive pulmonary disease (COPD) and clinical characteristics remains unclear. This study aimed to investigate the inflammatory phenotypes COPD their association with characteristics.
The effect of serum uric acid (SUA) levels on lung function in chronic obstructive pulmonary disease (COPD) people remained unclear. We aimed to investigate the association between SUA and function.A cross-sectional study was performed measure 2797 consecutive eligible individuals. Of these, individuals our were divided into two groups, COPD group (n=1387) non-COPD (n=1410). diagnosis is defined as post-bronchodilator first second forced expiratory volume (FEV1)/forced vital capacity (FVC)...
Background Evidence regarding clinical features and outcomes of individuals with non-obstructive chronic bronchitis (NOCB) remains scarce, especially in never-smokers. We aimed to investigate the 1-year NOCB Chinese population. Methods obtained data on participants Early Chronic Obstructive Pulmonary Disease Study who had normal spirometry (post-bronchodilator forced expiratory volume 1 s/forced vital capacity ≥0.70). was defined as cough sputum production for at least 3 months two...
Background There are limited data on the clinical features and longitudinal prognosis of variable obstruction, particularly among never smokers different obstruction types. Therefore, we aimed to evaluate characteristics participants with determine relationship between development chronic obstructive pulmonary disease (COPD) decline lung function in a community-dwelling study Chinese, especially subtypes. Methods Participants preserved spirometry (postbronchodilator forced expiratory volume...