A5078222115- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Sepsis Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Obstructive Sleep Apnea Research
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Heme Oxygenase-1 and Carbon Monoxide
- Nosocomial Infections in ICU
- Neonatal Health and Biochemistry
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Function and Risk Factors
- interferon and immune responses
- Animal Virus Infections Studies
- Air Quality and Health Impacts
- Metabolism, Diabetes, and Cancer
- Viral gastroenteritis research and epidemiology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Healthcare cost, quality, practices
- Urban Green Space and Health
First Affiliated Hospital of Guangzhou Medical University
2021-2025
Guangzhou Medical University
2021-2025
State Key Laboratory of Respiratory Disease
2021-2025
Beijing Forestry University
2022-2023
Guangxi University
2023
Guangxi Veterinary Research Institute
2023
Guangxi Center for Disease Prevention and Control
2023
Wuzhou University
2022
Shanghai Jiao Tong University
2018
Abstract Background: Preserved ratio impaired spirometry (PRISm) refers to decreased forced expiratory volume in 1 s (FEV ) the setting of preserved ratio. Little is known about role PRISm and its complex relation with small airway dysfunction (SAD) lung volume. Therefore, we aimed investigate associations between SAD Methods: We conducted a cross-sectional community-dwelling study China. Demographic data, standard respiratory epidemiology questionnaire, spirometry, impulse oscillometry...
Abstract Background High Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte (MLR), Platelet-to-Lymphocyte (PLR) were associated with worse prognosis of patients sepsis. In-hospital mortality has been reported to be higher in coronary artery disease (CAD) and sepsis than those alone. However, the relationship between NLR, MLR, PLR septic remains unclear. The study aimed explore association 28-day all-cause CAD. Methods We performed an observational cohort CAD from Medical...
Atherogenic index of plasma (AIP) at baseline has been associated with increased morbidity and mortality from cardiovascular disease (CVD). However, the relationship between long-term AIP trajectories CVD remains unclear. Therefore, this study aimed to investigate associations incidence in English population. The data analysis was based on Longitudinal Study Aging (ELSA) 2004 2017. population consisted individuals aged 50 years older England. calculated as log10 (triglycerides/high-density...
With the wide spreading of mobile and Internet Things (IoT) devices, music cognition as a meaningful task for promotion has attracted lot attention around world. How to automatically generate score is an important part in cognition, which acts carrier so disposing huge quantity data IoT networks or Internet. For reason that computers lack domain knowledge cognitive ability, it hard recognize melody write while listening music. Therefore, system introduced cognate based on machine learning...
Background and objective: Spirometry is commonly used to assess small airway dysfunction (SAD). Impulse oscillometry (IOS) can complement spirometry. However, discordant spirometry IOS in the diagnosis of SAD were not uncommon. We examined association between within a large cohort subjects identify variables that may explain findings. Methods: 1,836 from ECOPD underwent questionnaires, symptom scores, spirometry, IOS, 1,318 by CT. assessed with R5-R20 > upper limit normal (ULN) two three...
The role of airway impairment assessed by impulse oscillometry (IOS) in patients with chronic obstructive pulmonary disease (COPD) remains unclear. Therefore, this study aimed to analyze the proportion and clinical characteristics IOS across COPD severities, explore whether is a subtype COPD.This was based on cross-sectional data from ECOPD cohort Guangdong, China. Subjects were consecutively recruited July 2019 August 2021. They filled out questionnaires underwent lung function tests,...
Background: High blood eosinophil count (BEC) is a useful biomarker for guiding inhaled corticosteroid therapy in patients with chronic obstructive pulmonary disease (COPD), yet its implications community setting remain underexplored. This study aimed to elucidate the clinical characteristics and outcomes of COPD high BEC within Chinese community. Methods: We obtained baseline 2-year follow-up data from (post-bronchodilator forced expiratory volume 1 second/forced vital capacity <0.70) Early...
Studies on consistency among spirometry, impulse oscillometry (IOS), and histology for detecting small airway dysfunction (SAD) remain scarce. Considering invasiveness of lung histopathology, we aimed to compare spirometry IOS with chest computed tomography (CT) SAD detection, evaluate clinical characteristics subjects assessed by these three techniques. We collected baseline data from the Early COPD (ECOPD) study. CT-defined was defined as parametric response mapping quantifying (PRMfSAD) ≥...
PRISm is regarded as a COPD precursor, but whether this varies by smoking status remains unclear. Are annual lung function decline and the risk of developing airflow limitation different among subtypes status? 2850 participants from 15-year population-based prospective cohort were included in analysis. Participants categorized into three groups: never smokers with normal spirometry (normal control), (NS-PRISm), ever (ES-PRISm). We compared groups. control group exhibited faster function,...
The triglyceride-glucose (TyG) index was associated with higher risk of mortality in individuals Cardiovascular-Kidney-Metabolic (CKM) syndrome stages 0-3. However, the relationship between cumulative TyG (cumTyG) and incidence stroke remains unclear CKM Participants stage 0-3 were enrolled from China Health Retirement Longitudinal Study (CHARLS) 2011 to 2015. calculated as ln [fasting triglyceride (mg/dL)×fasting glucose (mg/dL)/2], cumTyG, an area-under-the-curve estimate (mean × time...
Preserved ratio impaired spirometry (PRISm), which identifies a population at high risk for COPD, has drawn increasing attention. However, definitions PRISm vary across studies, and researches comparing these are limited. We aim to assess the agreement, clinical features, prevalence of defined by restrictive spirometric pattern (RSP) method [that is forced vital capacity (FVC) method] versus expiratory volume in first second (FEV1) fixed values lower limit normal (LLN). All 1862 participants...
The interferon (IFN) system is an extremely powerful antiviral response in animal cells. subsequent effects caused by porcine astrovirus type 1 (PAstV1) IFN activation are important for the host's to viral infections. Here, we show that this virus, which causes mild diarrhea, growth retardation, and damage of villi small intestinal mucosa piglets, induces upon infection PK-15 Although IFN-β mRNA was detected within infected cells, usually occurs during middle stages infection, after genome...
Abstract Background Sepsis is a common cause of mortality in critically ill patients, and chronic obstructive pulmonary disease (COPD) one the most comorbidities septic patients. However, impact COPD on patients with sepsis remained unclear. Therefore, purpose this study aimed to assess effect prognosis based Medical Information Mart for Intensive Care (MIMIC-III) database. Methods In retrospective (MIMIC)-III database version 1.4 (v1.4), we collected clinical data 28-day all-cause from...
Abstract Background The lack of simple and affordable spirometry has led to the missed delayed diagnoses chronic respiratory diseases in communities. PUS201P is a portable developed solve this problem. Objective We aimed verify consistency spirometer with conventional Jaeger spirometer. Methods In cross-sectional study, we randomly recruited 202 subjects aged > 40 years. Testing were performed on all participants. compared forced expiratory volume one second (FEV 1 ), vital capacity...
The inter-relationships among neutrophilic airway inflammation, air trapping and future exacerbation in chronic obstructive pulmonary disease (COPD) remain unclear.To evaluate the associations between sputum neutrophil proportions COPD to determine whether these are modified by significant trapping.Participants with completed data were included followed up first year Early Chronic Obstructive Pulmonary Disease study (n=582). Sputum high-resolution CT-related markers measured at baseline....