A5101771023- Transplantation: Methods and Outcomes
- Extracellular vesicles in disease
- Renal Transplantation Outcomes and Treatments
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organ Transplantation Techniques and Outcomes
- Viral Infections and Immunology Research
- Renal Diseases and Glomerulopathies
- Polyomavirus and related diseases
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Pneumocystis jirovecii pneumonia detection and treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Yersinia bacterium, plague, ectoparasites research
- Anesthesia and Pain Management
- NF-κB Signaling Pathways
- Pain Mechanisms and Treatments
- Anorectal Disease Treatments and Outcomes
- Phytochemistry and Biological Activities
- Respiratory and Cough-Related Research
- Inflammatory Biomarkers in Disease Prognosis
- Inhalation and Respiratory Drug Delivery
- Phytochemical Studies and Bioactivities
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ocular Surface and Contact Lens
St. Joseph's Hospital and Medical Center
2018-2024
St. Joseph's Hospital
2019-2023
Creighton University
2023
Phoenix (United States)
2023
Johns Hopkins University
2021
JSS Academy of Higher Education and Research
2020
Linköping University
2016
Accumulation of senescent cells contributes to age-related diseases including idiopathic pulmonary fibrosis (IPF). Insulin-like growth factor binding proteins (IGFBPs) regulate many biological processes; however, the functional contributions IGFBP2 in lung remain largely unclear. Here, we report that intranasal delivery recombinant protects aged mice from weight loss and demonstrated antifibrotic effects after bleomycin injury. Notably, human-Igfbp2 transgenic reveal reduced senescence...
PEG-conjugated collagen-like peptides promote corneal regeneration in a pig cornea.
Regulatory dendritic cells (DCreg) promote transplant tolerance following their adoptive transfer in experimental animals. We investigated the feasibility, safety, fate, and impact on host T of donor monocyte-derived DCreg infused into prospective, living liver patients, 7 days before transplantation. The expressed a tolerogenic gene transcriptional profile, high cell surface programed death ligand-1 (PD-L1):CD86 ratios, IL-10/no IL-12 productivity poor ability to stimulate allogeneic...
The long-term function of transplanted organs, even under immunosuppression, is hindered by rejection, especially chronic rejection. Chronic rejection occurs more frequently after lung transplantation, termed allograft dysfunction (CLAD), than transplantation other solid organs. Pulmonary infection a known risk factor for CLAD, as lungs are constantly exposed to the external environment; however, mechanisms which respiratory infections lead CLAD poorly understood. role extracellular vesicles...
Chronic lung allograft dysfunction (CLAD), is a major hurdle for long-term survival after transplant and roughly 50% of recipients (LTxRs) develop CLAD within 5 years. The mechanisms development remain unknown. Donor-specific immune responses to HLA self-antigens (SAgs) are vital the pathogenesis CLAD. Reduction in Club cell secretory protein (CCSP) has been reported bronchoalveolar lavage (BAL) fluid samples from LTxRs with bronchiolitis obliterans syndrome (BOS). CCSP levels BAL antibodies...
The present study aimed to evaluate standardized aqueous Tribulus terristris (nerunjil) extract on the pain threshold response in streptozotocin (STZ)‐induced diabetic neuropathic model rats. After a single injection of STZ (40 mg/kg; i.p.), Wistar male rats were tested by thermal and chemical‐induced models. Diabetic exhibited significant hyperalgesia, these left untreated for first four weeks. Thereafter, treatment was initiated continued up week‐8. All except vehicle‐treated group...
Epithelial–mesenchymal transition (EMT) has been implicated to play a role in chronic lung allograft dysfunction (CLAD). Liver kinase B1 (LKB1), tumor suppressor gene, can regulate EMT. However, its CLAD development following transplantation remains unknown. Using qRT-PCR, biopsies from transplant recipients with bronchiolitis obliterans syndrome (BOS) demonstrated significant downregulation of LKB1 (p = .0001), compared stable biopsies. To determine the EMT development, we analyzed human...
In the realm of biomedical advancement, extracellular vesicles (EVs) are revolutionizing our capacity to diagnose, monitor, and predict disease progression. However, comprehensive exploration clinical application EVs face significant limitations due current isolation techniques. The size exclusion chromatography, commercial precipitation reagents, ultracentrifugation frequently employed, necessitating skilled operators entailing challenges related consistency, reproducibility, quality,...
We conducted a randomized, placebo-controlled, double-blind study of pediatric lung transplant recipients, hypothesizing that rituximab plus rabbit anti-thymocyte globulin induction would reduce de novo donor-specific human leukocyte antigen antibodies (DSA) development and improve outcomes. serially obtained clinical data, blood, respiratory samples for at least one year posttransplant. analyzed peripheral blood lymphocytes by flow cytometry, serum antibody development, viral infections...
Abstract Purpose Our group has proposed that aspiration of gastric contents leads to exposure normally sequestered lung self-antigens (SAgs), specifically collagen-V (Col-V) and K-α-1-tubulin (Kα1T), which elicits an immune response characterized by increasing concentrations self-antibodies (SAbs) anti-Col-V anti-Kα1T. We sought establish the point prevalence abnormally elevated SAbs among patients with pathological gastroesophageal reflux disease (GERD) and/or hiatal hernia undergoing...