A5064271463- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cytokine Signaling Pathways and Interactions
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Reproductive System and Pregnancy
- Lipoproteins and Cardiovascular Health
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Psoriasis: Treatment and Pathogenesis
- Angiogenesis and VEGF in Cancer
- Gestational Diabetes Research and Management
- Apelin-related biomedical research
- Maternal and fetal healthcare
- Cancer Immunotherapy and Biomarkers
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer Research and Treatments
- Parasitic Diseases Research and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Bioactive Compounds and Antitumor Agents
- Cardiovascular Health and Risk Factors
- Pregnancy and Medication Impact
- Heart Rate Variability and Autonomic Control
Tianjin University
2025
Chinese People's Armed Police Force
2009-2024
Chinese People's Armed Police General Hospital
2019-2024
Pingjin Hospital
2017-2018
Logistics University of People's Armed Police Force
2015-2017
Tianjin Medical University
2013-2016
The First Affiliated Hospital, Sun Yat-sen University
2015
Sun Yat-sen University
2015
Chinese People's Armed Police Force Medical College Affiliated Hospital
2009
Preeclampsia is a pregnancy‑specific disease characterized by hypertension as well proteinuria after the 20th week of pregnancy. Animal models are effective tools for studying pathogenesis, diagnostic criteria and treatment methods preeclampsia. The present study sought to establish evaluate preeclampsia‑like Sprague Dawley (SD) rat model using N‑nitro‑L‑arginine methyl ester (L‑NAME). Rats were randomly assigned 7 groups (n=10 in each): Control rats treated with low‑dose L‑NAME (40 mg/kg...
This study aimed to explore the expression characteristics of miRNAs in cardiovascular diseases (CVD) and depression within a plateau environment, better understand their potential role Plateau Psycho-CVD. A prospective design was employed analyze circulating small RNAs from 20 subjects using high-throughput sequencing technology. Participants were divided into four groups (C, PPC, PP, PC) for comparative analysis. Differentially expressed selected further functional enrichment The findings...
CD44(+) human ovarian cancer stem cells (CSCs) and CSC-like have been identified characterized. Compelling evidence has revealed that CD44 is involved in the occurrence development of cancers. Our previous study showed sphere-forming (SFCs) from cell line SKOV-3 had CSC capacity. Therefore, present study, we aimed to investigate effects mechanisms anti-CD44 monoclonal antibody A3D8 on proliferation apoptosis SFCs explore novel strategies for treatment cancer.We investigated using MTS assay,...
Inflammation and hypoxia are involved in numerous cancer progressions. Reportedly, the toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) pathway hypoxia-inducible factor-1α (HIF-1α) activated closely related to chemoresistance poor prognosis of epithelial ovarian (EOC). However, potential correlation between TLR4/NF-κB HIF-1α remains largely unknown EOC. In our study, possible positive among TLR4, NF-κB, proteins was investigated EOC tissues. Our vitro results demonstrated that LPS...
Scope l ‐Carnitine (LC) is abundant in red meat and widely added to health supplements food. This study focuses on the adverse effects of oral supplementation 1.3% LC ApoE −/− mice whether parenteral administration (subcutaneously, sub) has any impact development atherosclerosis. Methods results Mice are randomly divided into three groups ( n = 15). All fed a high‐fat diet (HFD). The number Ly6C hi monocytes; degree atherosclerosis; plasma LC, γ‐butyrobetaine (γBB), trimethylamine‐N‐oxide...
Abstract Background Lp(a) and LDL-C are both risk factors of atherosclerotic cardiovascular disease (ASCVD). But there was a contradiction point in control. The appropriate level the prevention ASCVD is still pending. Objective To investigate correlation coronary lesion, find out balance Method 3449 patients were divided to heart (CAHD) Group Non-CAHD based on result angiography. clinical characteristics compared, Logistic regressions applied CAHD total, High-LDL-C (LDL-C ≥ 100 mg/dL)...
Abstract Destruction of endothelial cells (ECs) function is involved in the structural and functional pathophysiological processes preeclampsia (PE). Vascular injury may pre‐exist for several years women that develop PE pose increased risks hypertension, coronary artery disease, type‐2 diabetes mellitus. Previous findings showed Elabela (ELA), endogenous ligand apelin (APJ) receptor expressed mainly on ECs, play a protective role early pregnancy prevent PE. However, exact molecular...
Spinal cord injury (SCI) is considered to be primarily associated with loss of motor function and leads activate diverse cellular mechanisms in the central nervous system attempt repair damaged spinal tissue. Mir-155 has been reported involved both innate adaptive immune responses. But role still unknown. In our current study, deficiency displays increased myelin sparring enhanced SC process. The number T cells, B cells neutrophils are all significantly lower Mir-155(-/-) group than that WT...
The purpose of this study was to evaluate vascular function, including arterial resistance and endothelial by high-resolution sonography in an Nω -nitro-l-arginine methyl ester hydrochloride (l-NAME)-induced mouse model preeclampsia-like symptoms. Pregnant mice were subcutaneously injected with a saline solution (control; n = 10) or l-NAME (n between the 7th 18th days gestation. resistive index pulsatility (RI PI, indicators resistance) uteroplacental, umbilical, femoral, common carotid...
// Xiulong Niu 1, 2, * , Wenxing Liu Yue Wang 3 Xiaomei 4 Hongjian Zhang 1 Zhijun Li Hongzhao Yoichiro Iwakura 5 Weimin Deng Department of Immunology, Tianjin Key Laboratory Cellular and Molecular Diseases Microenvironment Ministry Education China, Medical University, 300070, China 2 Infectious Diseases, Hospital Affiliated to Logistics College Chinese People’s Armed Police Forces, 300162, Obstetrics Gynecology, University General Hospital, 300052, Research Administration Center, Tokyo...
Background Preeclampsia (PE) mainly occurs in pregnant women and is hereditary. Several genome-wide association studies (GWAS) on Caucasian samples have reported some gene loci that are associated with preeclampsia. However, these not reached consistent conclusions. No previous GWAS has examined preeclampsia the Chinese Han population.
Objective This study aimed to investigate the feasibility of blood oxygen level‐dependent magnetic resonance imaging (BOLD‐MRI) evaluate visceral adipose tissue (VAT) oxygenation in Zucker diabetic fatty (ZDF) rats and its associations with systemic metaflammation. Methods Five‐week‐old ZDF lean (ZL) were fed a high‐fat diet (HFD) for 18 weeks. A baseline BOLD‐MRI scan perirenal was performed after 8 weeks HFD feeding, then randomized receive pioglitazone or vehicle following 10 At...
Abstract Early warning of hypertensive disorder in pregnancy (HDP) can improve maternal and infant outcomes. However, few studies had evaluated the value high–normal blood pressure (BP) before onset HDP. This was a prospective cohort study to investigate relationship between high‐normal BP first half risk According maximum measured 20 +6 weeks gestation, divided into three groups: optimal (SBP < 120 mmHg DBP 80 mmHg), normal (120 ≤ SBP 130 or 85 (130 140 90 mmHg). The different levels HDP...
<title>Abstract</title> <bold>Background</bold>: The metabolic profiles of eicosanoids before the clinical onset preeclampsia remain incompletely understood. This study aimed to use a targeted metabolomic approach identify eicosanoid metabolites in first-trimester blood samples and assess their potential predict severe preeclampsia. <bold>Methods</bold>: We carried out nested case-control focusing on within prospective cohort 5,809 pregnant women. analyzed 45 participants who subsequently...
BACKGROUND Studies in ApoE knockout mice have shown that pseudolaric acid B (PB) can act as an immunomodulatory drug and attenuate atherosclerosis progression by modulating monocyte/macrophage phenotypes. Our previous study demonstrated high salt intake could shift the phenotype of monocytes/macrophages to inflammatory phenotype, this was related hypertension hypertensive left ventricular (LV) remodeling. However, no comprehensive assessment effects PB on LV remodeling has been conducted....