A5001650260- Bone and Dental Protein Studies
- Bladder and Urothelial Cancer Treatments
- Periodontal Regeneration and Treatments
- Gut microbiota and health
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Diet and metabolism studies
- Hepatocellular Carcinoma Treatment and Prognosis
- dental development and anomalies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Treatment and Research
- Multiple and Secondary Primary Cancers
- Thyroid Cancer Diagnosis and Treatment
- Heavy Metal Exposure and Toxicity
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Chromium effects and bioremediation
- Liver Disease Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Carcinogens and Genotoxicity Assessment
- Healthcare cost, quality, practices
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
First Affiliated Hospital of Zhengzhou University
2019-2025
The University of Texas Southwestern Medical Center
2022-2025
Icahn School of Medicine at Mount Sinai
2019-2025
Southwestern Medical Center
2023
Harold C. Simmons Comprehensive Cancer Center
2023
Shenzhen University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2017-2022
Columbia University
2010-2022
Nanjing University of Chinese Medicine
2019-2021
Tisch Cancer Institute
2020-2021
A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a drug-free, biodegradable nanomedicine acts against IBD by scavenging cell-free DNA (cfDNA) and reactive oxygen species (ROS). Polyethylenimine (PEI) was conjugated to antioxidative diselenide-bridged mesoporous organosilica nanoparticles (MONs) formulate (MON-PEI) exhibited high cfDNA binding affinity...
Brain-derived neurotrophic factor (BDNF) stimulates local dendritic mRNA translation and is involved in formation consolidation of memory. 2H,3H,6aH-pyrrolidino[2'',1''-3',2']1,3-oxazino[6',5'-5,4]-benzo[e]1,4-dioxan-10-one (CX614), one the best-studied positive AMPA receptor modulators (also known as ampakines), increases BDNF protein facilitates long-term potentiation (LTP) induction. Several other ampakines also improve performance various behavioral learning tasks. Since synthesis has...
Abstract Titanium dioxide nanoparticles (TiO 2 NPs) have potential applications as food additives, but concerns persist about their safety. Children are identified having the highest exposure and may face greatest health risks. However, toxicological sensitivity of TiO NPs in different ages is not clear. Here, a comparative toxicity study 3‐week (youth) 8‐week (adult) old Sprague‐Dawley rats reported following oral at doses 0, 10, 50, 200 mg kg −1 body weight per day for 30 days. The organ...
Enamelysin (MMP-20) is a tooth-specific matrix metalloproteinase that initially expressed by ameloblasts and odontoblasts immediately prior to the onset of dentin mineralization, continues be throughout secretory stage amelogenesis. During stage, enamel proteins are secreted rapidly cleaved into large number relatively stable cleavage products. Multiple proteinases present in developing matrix, precise role enamelysin processing unknown. We have expressed, activated, purified catalytic...
Observational data suggest an acquired prothrombotic state may contribute to the pathophysiology of COVID-19. These include elevated D-dimers observed among many COVID-19 patients. We present a retrospective analysis admission D-dimer, and D-dimer trends, 1065 adult hospitalized patients, across 6 New York Hospitals. The primary outcome was all-cause mortality. Secondary outcomes were intubation venous thromboembolism (VTE). Three-hundred-thirteen patients (29.4%) died, 319 (30.0%) required...
The gut microbiota is crucial in the pathogenesis of obesity. Abdominal obesity known to significantly increase risk metabolic syndrome and cardiovascular disease, so further study needed investigate changes intestinal microorganisms patients with excessive visceral fat. In our study, 41 people (n = 41) normal body mass index (BMI) (18.5 ≤ BMI < 23.9) were included divided into low fat area (L-VFA) group 23, VFA 100 cm
Sheath proteins designate low-molecular-weight non-amelogenin enamel polypeptides and their parent protein, which concentrate in the sheath space separating rod inter-rod (Uchida et al., 1995). Two porcine proteins, with apparent molecular weights of 13 15 kDa, are characterized by protein sequencing. The primary structures these match a portion derived amino acid sequences clones isolated from organ epithelia-specific cDNA library. RNA messages differ inclusion or deletion 45-nucleotide...
Dental enamel forms by matrix-mediated biomineralization. The components of the developing matrix are generally specific for that matrix. primary structures three proteins-amelogenin, tuftelin, and sheathlin (ameloblastin/amelin)—have been derived from cDNA sequences. Here we report cloning characterization mRNA encoding a fourth protein: enamelin. longest porcine enamelin clone has 3907 nucleotides, exclusive poly(A) tail. structure secreted protein is 1104 amino acids in length. Without...
Abstract Background Alcohol-induced intestinal dysbiosis disrupts and inflammatory responses are essential in the development of alcoholic fatty liver disease (AFLD). Here, we investigated effects Fmo5 on changes enteric microbiome composition a model AFLD dissected pathogenic role AFLD-induced pathology. Methods The expression profile data GSE8006 GSE40334 datasets were downloaded from GEO database. WGCNA approach allowed us to investigate AFLD-correlated module. DEGs used perform KEGG...
Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammation of the gastrointestinal tract. Oxidative stress plays a pivotal role in pathogenesis IBD. Selenium-containing amino acids reportedly have anti-oxidative and anti-inflammatory properties, but it remains unknown if selenium-containing can be used to treat This study aimed investigate effects two - selenocysteine selenocystine on oxidative mouse model dextran sulfate sodium (DSS)-induced IBD.C57BL/6 mice were...
Metabolic syndrome (MetS) is a wide-ranging disorder, which includes insulin resistance, altered glucose and lipid metabolism, increased blood pressure visceral obesity. MetS symptoms combine to result in significant increase cardiovascular risk. It therefore critical treat the early stages of disorder. In this study, 123 patients 304 controls were recruited determine whether gut microbiome plays role development progression. By using whole-genome shotgun sequencing, we found that...
It is predicted that by 2035, metabolic syndrome (MS) will be found in nearly more than half of our adult population, seriously affecting the health body. MS usually accompanied occurrence abnormal liver enzymes, such as elevated gamma-glutamyl transpeptidase (GGT). More and studies have shown gut microbiota involved MS; however, correlation between with GGT has not been studied comprehensively. Especially, there are few reports about its role physical examination population men GGT. By...
Objective The purpose of this manuscript is to identify longitudinal trajectories changes in triglyceride glucose (TyG) index and investigate the association TyG with risk lean nonalcoholic fatty liver disease (NAFLD). Methods Using data from 1,109 participants Health Management Cohort study, we used Latent Class Growth Modeling (LCGM) develop trajectories. a Cox proportional hazard model, relationship between incident NAFLD was analyzed. Restricted cubic splines (RCS) were visually display...
In mammals, the organic matrix of developing enamel is dominated by amelogenins. To investigate expression proteins secreted into matrix, we have constructed a porcine organ epithelia-specific cDNA library. The amelogenin fraction library was characterized cloning amelogenin-specific polymerase chain-reaction (PCR) amplification products, 5' and 3' rapid ends (RACE), helper phage rescue unamplified clones. Clones were that encode isoforms 173, 157, 56, 41, 40 amino acids in length. structure...
A population-based case-control study involving 601 incident cases of non-Hodgkin lymphoma (NHL) and 717 controls was conducted in 1996–2000 among Connecticut women to examine associations with exposure organic solvents. job-exposure matrix used assess occupational exposures. Increased risk NHL associated chlorinated solvents (odds ratio (OR) = 1.4, 95% confidence interval (CI): 1.1, 1.8) carbon tetrachloride (OR 2.3, CI: 1.3, 4.0). Those ever exposed any solvent work settings had a...
The development of clinically accessible biomarkers is critical for the early diagnosis gastric cancer (GC) in patients. High-throughput proteomics techniques could not only effectively generate a serum peptide profile but also provide new approach to identify potentially diagnostic and prognostic In this study, we aim discriminating GC. discovery cohort, screened potential using magnetic-bead-based purification matrix-assisted laser desorption/ionization time-of-flight mass spectrometry 64...
Objective: To investigate the correlation between structure and function alterations of gut microbiota biochemical indicators in males with hyperuricemia (HUA) high levels liver enzymes, order to provide new evidences therapeutic targets for clinical diagnosis treatment HUA. Methods: A total 69 patients HUA (HUA group) 118 healthy controls were enrolled this study. Their age, height, waist circumference, weight, pressure measured. The parameters such as fasting plasma glucose (FBG),...