A5104110975- Gut microbiota and health
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Probiotics and Fermented Foods
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cleft Lip and Palate Research
- Sexual function and dysfunction studies
- Helicobacter pylori-related gastroenterology studies
- Cancer, Lipids, and Metabolism
- Hepatitis C virus research
- Effects of Environmental Stressors on Livestock
- Bacterial biofilms and quorum sensing
- Esophageal Cancer Research and Treatment
- Sexuality, Behavior, and Technology
- Salivary Gland Disorders and Functions
- Orthodontics and Dentofacial Orthopedics
- Context-Aware Activity Recognition Systems
- Inflammatory Biomarkers in Disease Prognosis
- Genetics, Aging, and Longevity in Model Organisms
- Ion Transport and Channel Regulation
- Mobile Health and mHealth Applications
- Indigenous Studies and Ecology
Foshan University
2024
Huazhong University of Science and Technology
2024
Shanghai Jiao Tong University
2008-2023
Sichuan University
2017-2023
University of Oxford
2022-2023
Shanxi Agricultural University
2021-2022
Shanghai Chest Hospital
2022
First Affiliated Hospital of Zhengzhou University
2021-2022
Renji Hospital
2009-2021
Nanjing University of Chinese Medicine
2021
Importance Metabolomics reflect the net effect of genetic and environmental influences thus provide a comprehensive approach to evaluating pathogenesis complex diseases, such as depression. Objective To identify metabolic signatures major depressive disorder (MDD), elucidate direction associations using mendelian randomization, evaluate interplay human gut microbiome metabolome in development MDD. Design, Setting Participants This cohort study used data from participants UK Biobank (n = 500...
In order to investigate the modulatory effect of purple sweet potato anthocyanins (PSPAs) on human intestinal microbiota, PSPAs were prepared by column chromatography and their influence microbiota was analyzed monitoring bacterial populations analyzing short-chain fatty acid (SCFA) concentrations at different time points. The numbers (log10 cell/mL) Bifidobacterium Lactobacillus/Enterococcus spp., Bacteroides-Prevotella, Clostridium histolyticum, total bacteria after 24 h culture in...
The gut microbiota is crucial in the pathogenesis of obesity. Abdominal obesity known to significantly increase risk metabolic syndrome and cardiovascular disease, so further study needed investigate changes intestinal microorganisms patients with excessive visceral fat. In our study, 41 people (n = 41) normal body mass index (BMI) (18.5 ≤ BMI < 23.9) were included divided into low fat area (L-VFA) group 23, VFA 100 cm
Metabolic syndrome (MetS) is a wide-ranging disorder, which includes insulin resistance, altered glucose and lipid metabolism, increased blood pressure visceral obesity. MetS symptoms combine to result in significant increase cardiovascular risk. It therefore critical treat the early stages of disorder. In this study, 123 patients 304 controls were recruited determine whether gut microbiome plays role development progression. By using whole-genome shotgun sequencing, we found that...
Abstract The gut microbiome plays a fundamental role in host health and the fecal metabolome can be analysed to assess microbial activity used as an intermediate phenotype monitoring host-microbiome relationship. However, there is no established extraction protocol study of giant pandas. aim this research optimize from adult baby pandas for high throughput metabolomics analysis using gas chromatography-mass spectrometry (GC-MS). Fecal samples were collected eight pair twin Six different...
Gastrointestinal (GI) microbiota play an important role in promoting growth piglets. However, studies on composition at various stages are lacking. We measured body weights of Jinfen White and Mashen piglets every 7 days collected their fecal samples by rectal swabbing nine time points during suckling (1-28 days) nursery (35-70 to gain insight into variability piglet growth. The were characterized via 16S rRNA gene sequencing analyze the effects microbial diversity development preliminarily....
Carotid atherosclerosis (CAS) is a reflection of systemic and the main pathological processes cardiovascular disease (CVD), namely, carotid intima-media thickening, plaque formation, stenosis. Accumulating evidence indicates that gut microbiota plays an important role in CVD gut-brain disorders, but associations composition metabolites microbiome with CAS have not been studied comprehensively. We performed genome-wide association study 31 patients 51 healthy controls using whole-genome...
The health benefits of nutritional interventions targeting the gut microbiota in early life are transient, such as probiotics, prebiotics, and synbiotics. This study sought to determine whether supplementation with Bifidobacterium infantis 79 (B79), 2'-fucosyllactose (2'-FL), or both (B79+2'FL) would lead persistent neonatal BALB/c mice. We found that at postnatal day (PND) 21, Ki67 MUC2 expression increased, while total serum IgE content decreased B79, 2'-FL, B79+2'-FL groups. structure...
To investigate the prognostic significance of systemic immune-inflammation index (SII) in patients after radical cholecystectomy for gallbladder cancer (GBC) using overall survival (OS) as primary outcome measure.Based on data from a multi-institutional registry with GBC, significant factors were identified by multivariate Cox proportional hazards model. A novel staging system was established, visualized nomogram. The response to adjuvant chemotherapy compared between different subgroups...
Salmonella enterica is one of the most important zoonotic pathogens causing foodborne gastroenteritis worldwide. Outer membrane vesicles (OMVs) are lipid-bilayer produced by Gram-negative bacteria, which contain biologically active components. We hypothesized that OMVs an weapon S. to initiate enteric diseases pathologies. In this study, effects (SeOMVs) on intestinal microbiota and barrier function were investigated. vitro fecal culture experiments showed alpha diversity indexes composition...
We aimed at evaluating the risk of liver cancer in different levels HBsAg among Chinese men and women. carried out a nested case-control study including 363 cases 3,511 controls two population-based cohorts Shanghai. Plasma samples collected enrollment were quantified for using Architect QT assay. Conditional logistic regression was performed to estimate odds ratios (ORs) 95% confidence intervals (95% CIs) cancer, with adjustment potential confounders. detected 6.29% control subjects overall...
Cold stress influences intestinal processes, causing physiological and immunological responses in animals. Intestinal microbiota participates maintaining the stability of environment. However, phenotypic characteristics effects porcine changes under cold conditions remain poorly understood. Here, fecal tolerant breed (Mashen) sensitive (Duroc-Landrace-Yorkshire) was transferred to germ-free mice, respectively. After a exposure (4°C) for 21 days, function microbe mice were explored. The...
Objectives Observational studies of type 2 diabetes (T2D) and lung cancer risk are limited controversial. We thus examined the association between T2D incident using a cohort design. Setting Data from two ongoing population-based cohorts (the Shanghai Men's Health Study, SMHS, 2002–2006 Women's SWHS, 1996–2000) were used. Cox proportional-hazards regression models with as time-varying exposure modelled to estimate HRs 95% CIs. Participants The study population included 61 491 male...
Objective : To evaluate the effects of lip repair on maxillofacial development patients with unilateral cleft or without palate. Design Retrospective. Patients A total 75 were recruited, including 38 surgical complete and alveolus 37 palate who had but not repair. As controls, no selected. All subjects divided according to two growth stages: before pubertal peak (GS1) after (GS2). Interventions Lateral cephalograms all obtained. Main Outcome Measures Cephalograms analyzed compared in study...
Objective To understand the dynamic structure, function, and influence on nutrient metabolism in hosts, it was crucial to assess genetic potential of gut microbial community yaks different ages. Methods The denaturing gradient gel electrophoresis (DGGE) profiles Illumina-based metagenomic sequencing colon contents 15 semi-domestic were investigated. Unweighted pairwise grouping method with mathematical averages (UPGMA) clustering principal component analysis (PCA) used analyze DGGE...
Abstract Background Hepatitis B surface antigen (HBsAg) and viral load are both hallmarks of hepatitis virus (HBV) infection have potential to stratify liver cancer risk. Methods We carried out a nested case–control study including 211 cases 221 controls who were seropositive for HBsAg within two population‐based cohorts in Shanghai. Logistic regression was performed estimate the odds ratios (ORs) 95% confidence intervals (CIs). Results Risk positively related increasing levels HBV‐DNA...
No AccessJournal of UrologyAdult Urology1 Jul 2011Oral Tadalafil Administration Plus Low Dose Vasodilator Injection: A Novel Approach to Erection Induction for Penile Color Duplex Ultrasound Yang Yang, Jian-lin Hu, Yi Ma, Hong-xiang Wang, Zhe Chen, Jian-guo Xia, Yi-xin Yi-ran Huang, and Bin Chen YangYang Department Urology, Renji Hospital, Shanghai Jiaotong University, School Medicine, Shanghai, People's Republic China Institute Andrology, , HuJian-lin Hu MaYi Ma WangHong-xiang Wang ChenZhe...