A5100364467- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Intermetallics and Advanced Alloy Properties
- Bone and Joint Diseases
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Advancements in Semiconductor Devices and Circuit Design
- Platelet Disorders and Treatments
- Ubiquitin and proteasome pathways
- Bioinformatics and Genomic Networks
- Renal cell carcinoma treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroblastoma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Nanowire Synthesis and Applications
- Acute Myeloid Leukemia Research
- High Temperature Alloys and Creep
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
First Affiliated Hospital of Xi'an Jiaotong University
2021-2024
Hunan University
2024
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2024
Lanzhou University Second Hospital
2023
Lanzhou University
2023
Second Affiliated Hospital of Guangzhou Medical University
2013-2022
Fudan University Shanghai Cancer Center
2022
Abstract Cucurbitacin B (CuB) is a widely available triterpenoid molecule that exhibits various biological activities. Previous studies on the anti-tumour mechanism of CuB have mostly focused cell apoptosis, and research ferroptosis-inducing effect has rarely been reported. Herein, we first discovered excellent cytotoxicity towards human nasopharyngeal carcinoma cells elucidated its potential mechanisms. Morphology alterations mitochondrial ultrastructure, as observed via transmission...
The complex immunosuppressive tumour microenvironment (TME) and lack of tumour-specific targets hinder the application chimeric antigen receptor (CAR) T cells in treatment solid tumours. Combining local with CAR cell immunotherapy may regulate TME enhance killing potency Here, we show that AXL, which is highly expressed non-small lung cancer (NSCLC) but not normal tissues, might be a target for therapy. AXL-CAR alone cause moderate regression subcutaneous pulmonary metastatic cell-derived...
The incidence of repetitive mild traumatic brain injury (rmTBI), one the main risk factors for predicting neurodegenerative disorders, is increasing; however, its underlying mechanism remains unclear. As suggested by several studies, ferroptosis possibly related to TBI pathophysiology, but effect on rmTBI rarely studied. Mesenchymal stromal cells (MSCs), most studied experimental in stem cell therapy, exert many beneficial effects diseases central nervous system, yet evidence regarding role...
Abstract Background Polygonum multiflorum (PM), a widely used traditional Chinese medicine herb, is divided into two forms, namely raw polygonum (RPM) and praeparata (PMP), according to the processing procedure. Emerging data has revealed differential hepatotoxicity of RPM PMP, however, its potential mechanism still unclear. Methods In our study, we investigated PMP exerted in C57BL/6 mice. First, sera were collected for biochemical analysis HE staining was applied examine morphological...
Abstract Melanoma is an aggressive malignant tumor with a poor prognosis. Vemurafenib (PLX4032, vem) applied to specifically treat BRAF V600E‐mutated melanoma patients. However, prolonged usage of vem makes patients resistant the drug and finally leads clinical failure. We previously tested combination regimen tubulin inhibitor VERU‐111 vem, as well USP14 selective b‐AP15 in both which have showed profound therapeutic effects overcoming resistance vitro vivo. Most importantly, we discovered...
The last decade has witnessed revolutionary advances taken in immunotherapy for various malignant tumors. However, immune-related molecules and their characteristics the prediction of clinical outcomes response clear cell renal carcinoma (ccRCC) remain largely unclear. C-C Motif Chemokine Ligand 4 (CCL4) was extracted from intersection analysis common differentially expressed genes (DEGs) four microarray datasets Gene Expression Omnibus database gene lists ImmPort using Cytoscape plug-ins...
Hepatocellular carcinoma (HCC) is a highly lethal and heterogeneous disease with poor prognosis no effective treatments. Herein, we presented pathway-guided computational framework to establish metabolic signature the capacity for HCC prediction. By using TCGA dataset as training cohort (n = 365), built an eight-gene (ACADS, ALDH1A2, FTCD, GOT2, GPX7, HADHA, LDHA UGT2A1) risk score called MGP from 20 pathways downregulated in HCC. The robustness of model was successfully validated seven...
Abstract To assess the efficacy, safety, and feasibility of a separate inserted positioning fine needle-mediated breathing-control technique applied to computed tomography (CT)-guided percutaneous puncture for biopsy or microwave ablation (MWA) small lung/liver nodules near diaphragm. Total 46 patients with pulmonary/liver (≤ 3 cm in size) diaphragm(nodule within 1 distance diaphragm)were undergone ( n = 15) MWA (n 31) under guidance CT, was precise punctures. CT plain scan performed monitor...
Abstract Therapeutic agents targeting cytokine-cytokine receptor (CK-CKR) interactions lead to the disruption in cellular signaling and are effective treating many diseases including tumors. However, a lack of universal quick access annotated structural surface regions on CK/CKR has limited progress structure-driven approach developing targeted macromolecular drugs precision medicine therapeutics. Herein we develop CytoSIP (Single nucleotide polymorphisms (SNPs), I nterface, P henotype),...
ABSTRACT Background Immunotherapy has shown promise for bladder cancer (BC) treatment but is effective only in a subset of patients. Understanding the tumor microenvironment (TME) and its regulators, such as expression N6‐methyladenosine (m6A) may improve therapeutic outcomes. This study focuses on role IGF2BP2, an m6A reader, modulating BC TME. Methods Transcriptomic single‐cell RNA‐seq data from public databases were analyzed to identify subgroups investigate IGF2BP2's Clustering PCA...
Objective To explore the effects of BIODEX training system on walking ability in stroke patients with hemiplegia.Methods 56 cases hemiplegia were randomly assigned into treatment group and control group.All had received same conventional rehabilitation treatment.The (28 cases) was treated balance traditional training.The used training.Clinical assessment assessed by lower limber motor function(Fugl-Meyer scale),Berg scale(BBS),Functional Ambulation Category (FAC),and Biodex function before...
Abstract The application of Chimeric antigen receptor (CAR) T cells in solid tumors is hindered by lack tumor specific targets and inefficient cell infiltration tumor. It has been postulated that AXL may be an ideal immunotherapy target for non-small-cell lung cancer (NSCLC). Here, we screened 208 non-tumor samples from 22 types human organs or tissues 90 NSCLC patients immunohistochemistry Western Blotting identified was rarely expressed normal but highly 69% samples, suggesting CAR therapy...