A5100359885- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Multiple and Secondary Primary Cancers
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Pectus Deformity Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Tracheal and airway disorders
- Silicon Carbide Semiconductor Technologies
- Cardiac tumors and thrombi
- Advancements in Semiconductor Devices and Circuit Design
- Esophageal and GI Pathology
- Sarcoma Diagnosis and Treatment
- Infectious Aortic and Vascular Conditions
- Lung Cancer Research Studies
- Semiconductor materials and devices
- Mesenchymal stem cell research
- Dupuytren's Contracture and Treatments
- Cancer Mechanisms and Therapy
Central South University
2016-2025
Second Xiangya Hospital of Central South University
2016-2025
Zhejiang University
2024
Shenzhen Institute for Drug Control
2022-2024
National Engineering Research Center of Electromagnetic Radiation Control Materials
2022-2023
University of Electronic Science and Technology of China
2022-2023
Shenyang Jianzhu University
2023
Jilin Academy of Agricultural Machinery
2022
Henan Agricultural University
2020
Ministry of Agriculture and Rural Affairs
2020
Routine clinical surveillance involves serial radiographic imaging following radical surgery in localized non-small cell lung cancer (NSCLC). However, such can detect only macroscopic disease recurrence and is frequently inconclusive. We investigated if detection of ctDNA before after resection NSCLC identifies the patients with risk relapse, furthermore, informs about response to management.We recruited a total 77 patients. A high-throughput 127 target-gene capture technology...
Diagnosing and treating patients with multiple primary lung cancers (MPLCs) bring challenges to the clinic, preliminary evidence has revealed unsatisfying outcomes after targeted therapy immunotherapy. Therefore, we surveyed genomic profiles of MPLCs their possible associations tumor mutation burden (TMB), programmed death-ligand 1 (PD-L1), immune cell infiltration landscape.A total 112 surgically resected 294 tumors were eligible, 255 sequenced using a 1021-gene panel. Immunohistochemistry...
Abstract Gefitinib is suitable for the treatment of locally advanced or metastatic non–small cell lung cancer. However, development acquired resistance limits its long-term efficacy in regardless significant clinical benefit to patients. Therefore, elucidate mechanism gefitinib addition target gene mutation may greatly increase efficacy. It was found first that N6-methyladenosine RNA demethylase FTO significantly enriched serum exosomes gefitinib-resistant (GR) patients compared with...
Objective: Aryl hydrocarbon receptor (AhR) is a transcription factor. It reported that AhR associated with non-small cell lung cancer (NSCLC), but the mechanisms underlying this relationship remain unclear. Therefore, we investigated role of in NSCLC to elucidate mechanisms. Methods: We collected clinical samples and constructed overexpression knockdown lines investigate tumorigenicity vivo vitro. Furthermore, performed ferroptosis induction experiment chromatin immunoprecipitation...
Adenocarcinoma of the uterine cervix has been reported to be increasing among young white women and earlier studies suggest a birth cohort pattern for observed increase. No study, however, examined time trends adenocarcinoma by cohort. Using Surveillance, Epidemiology, End Results (SEER) data through 1990, current study is designed examine invasive An age-period-cohort model was fitted annual age-specific rates identify components penod as determinants trends. The results from this clearly...
Abstract Prostate cancer is the most frequently diagnosed in males United States, accounting for an estimated 186,320 new cases 2008. There are striking racial or ethnic differences prostate incidence and mortality rates with Black 1.6 times more likely to be 2.4 die than Whites. Stage at diagnosis a key prognostic factor survival, African-Americans generally advanced stage. To identify factors that explain race-stage disparity cancer, we conducted population-based case-case study of 251...
Abstract Purpose We had previously developed highly sensitive DNA methylation detection to diagnose lung cancer in patients with pulmonary nodules. To validate this approach and determine clinical utility Chinese indeterminate nodules, we assessed the diagnostic accuracy for early stage plasma samples. Experimental design Patients CT-detected small nodules (diameter ≤ 3.0 cm) were included. Cases ( n = 163) staged IA or IB non-small cell (NSCLC), while controls 83) non-cancerous lesions....
Background. Adenocarcinoma of the gastric cardia has been be increasing in Connecticut, and risk factors responsible for incidence are unknown. This study examined pattern adenocarcinoma distal stomach Connecticut during past decades identified components birth cohort, period, age as determinants observed time trends by regression modeling. Methods. was based on all histologically confirmed incident cases reported to Tumor Registry between 1955 1989. Stomach cancers were grouped into cardia,...
There are limited population-based data regarding pediatric herpes zoster (HZ).Children aged <12 years with varicella infections between 2000 and 2006 were identified from a national database followed-up for diagnosis of HZ until December 2008. Since routine vaccination program was started in 2004, vaccinated children without medically attended 2004 2006, 2008.Of 27 517 varicella, 428 developed HZ. The incidence 262.1 per 100 000 person-years. Of 25 132 106 93.3 mean duration to 4.12 years....
Abstract Background Diagnosing and treating synchronous multiple primary lung cancers (sMPLC) are complex challenging. This study aimed to report real‐world data on the comprehensive diagnosis treatment of patients with early‐stage sMPLC. Materials Methods A single‐center cohort was carried out a large number sMPLC were included. single‐ or two‐stage surgery performed remove co‐existing lesions. The “X” strategies, including ablation, SBRT, EGFR‐TKIs treatment, applied treat high‐risk...
Paragangliomas are rare neoplasms arising from extra-adrenal chromaffin cells, with mediastinal paragangliomas representing an exceptionally subset. This report details the surgical management of a complex paraganglioma case, presenting refractory hypertension and invasion critical surrounding structures. A comprehensive review current literature is included to underscore existing cases, enhance clinical awareness, share our insights experience in diagnosis treatment this challenging...
With the wide use of CT scan in clinical practice, more lung cancer was diagnosed resectable stage. Pathological examination and genetic testing have become a routine procedure for adenocarcinoma following radical resection. This study analyzed special pathological components gene mutations to explore their relationship with characteristics overall survival. Clinical, pathological, mutation data from 1,118 patients were collected. All underwent surgery at Department Thoracic Surgery, Second...
Abstract 3D concrete printing is an innovative technology poised to transform the construction industry by enabling automated, layer-by-layer creation of structures directly from digital models. This approach offers numerous advantages over traditional methods, including reduced labor costs, faster build times, and ability produce complex geometries with high precision. However, unlike conventional mold-cast concrete, printable must support itself without external formwork, posing...
Pembrolizumab and tislelizumab have shown substantial clinical benefits in perioperative treatment of resectable non-small cell lung cancer (NSCLC), yet no direct head-to-head trial has established which is optimal. This study, for the first time, aimed to directly compare efficacy safety neoadjuvant pembrolizumab plus chemotherapy versus NSCLC using real-world data. Data patients with treated or followed by radical resection between December 2017 August 2023 at Second Xiangya Hospital...
Polyetheretherketone (PEEK) is a widely used material in bone tissue engineering due to its favorable mechanical properties and radiolucency. However, bioinert nature lack of osteogenic activity restrict ability support effective regeneration. In this study, novel APS-coated plasma-treated sulfonated bioactive PEEK scaffold (APS/PSBPK) was developed overcome these limitations. The integrates strontium-doped glass (SrBG) enhance biocompatibility potential, while astragalus polysaccharide...
Distant metastasis of non-small cell lung cancer (NSCLC) leads to high postoperative recurrence and low long‑term survival rates. Deregulation microRNA (miR)-200b has been demonstrated be associated with NSCLC metastasis. However, the underlying molecular mechanism miR‑200b in mediating migration invasion remains fully elucidated. In current study, reverse transcription‑quantitative polymerase chain reaction data indicated that was significantly downregulated several lines, including A549,...
The microRNA (miR)-200 family has been demonstrated to be associated with the tumorigenesis and progression of multiple types human cancer, including non-small cell lung cancer (NSCLC). As a member miR-200 family, miR-429 was recently identified have an oncogenic role in NSCLC. However, miR‑429 NSCLC growth as well underlying mechanism remains fully elucidated. In present study, line H1229 transfected mimic or inhibitor, respectively. It observed that overexpression led significant increase...
Significant progress has been made in designing bone materials capable of directing endogenous cells to promote vascularized regeneration. However, current strategies lack regulation the specific cell populations for regeneration, thus leading adverse tissue formation and decreased regenerative efficiency. Here, we engineered a biomaterial regulate adhesion The works by presenting two synthetic ligands, LLP2A LXW7, explicitly targeting integrins α4β1 αvβ3, respectively, expressed on surfaces...
Abstract Background To explore the possible carcinogenesis and help better diagnose treat patients with synchronous multiple primary lung cancers (sMPLC), we systematically investigated genetic DNA methylation profiles of early-stage sMPLC single cancer (SPLC) explored immune in tumor microenvironment. Methods Hundred ninety-one 191 nodules SPLC group 132 295 were enrolled. All samples subjected to wide panel-genomic sequencing. Genome-wide was assessed using Infinium Human Methylation 850 K...
Abstract Background Aortoesophageal fistula (AEF) is an extremely rare and highly fatal complication leading to a high risk of morbidity mortality. Successful management AEF after esophagectomy for esophageal carcinoma has rarely been reported in the literature. Case presentation Here we present case 44-year-old female with complications carcinoma, mainly presented as vomiting blood. Both computed tomographic tomography angiography chest showed bilateral pleural effusion atelectasis, while...