A5101989415- Cancer-related molecular mechanisms research
- Orthopaedic implants and arthroplasty
- RNA modifications and cancer
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Inflammatory mediators and NSAID effects
- Asthma and respiratory diseases
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Alkaloids: synthesis and pharmacology
- Orthopedic Infections and Treatments
- Bone Metabolism and Diseases
- Cardiac Imaging and Diagnostics
- Chemical synthesis and alkaloids
- Total Knee Arthroplasty Outcomes
- Epigenetics and DNA Methylation
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Cardiovascular Function and Risk Factors
- Hemodynamic Monitoring and Therapy
- Cell Adhesion Molecules Research
- Lung Cancer Diagnosis and Treatment
- Gut microbiota and health
- Cancer-related gene regulation
Peking University
2016-2025
Xiangya Hospital Central South University
2019-2024
Central South University
2019-2024
Xiangyang Central Hospital
2023-2024
Hunan University of Traditional Chinese Medicine
2024
Sichuan Academy of Traditional Chinese Medicine
2024
Chengdu Third People's Hospital
2024
West China Second University Hospital of Sichuan University
2022-2024
First Hospital of China Medical University
2024
Dalian Medical University
2024
In the treatment of most malignancies, radiotherapy plays a significant role. However, resistance cancer cells to ionizing radiation (IR) is main reason for failure radiotherapy, which causes tumor recurrence and metastasis. this study, we confirmed that GPR162, an orphan receptor in G-protein-coupled family, acted as novel sensitizer by interacting with stimulator interferon genes (STING), targeted DNA damage responses, activated IRF3, accelerated activation type I system, promoted...
Objective: Aryl hydrocarbon receptor (AhR) is a transcription factor. It reported that AhR associated with non-small cell lung cancer (NSCLC), but the mechanisms underlying this relationship remain unclear. Therefore, we investigated role of in NSCLC to elucidate mechanisms. Methods: We collected clinical samples and constructed overexpression knockdown lines investigate tumorigenicity vivo vitro. Furthermore, performed ferroptosis induction experiment chromatin immunoprecipitation...
Abstract Background This study aimed to explore the incidence of occult lymph node metastasis (OLM) in clinical T 1 − 2 N 0 M (cT ) small cell lung cancer (SCLC) patients and develop machine learning prediction models using preoperative intratumoral peritumoral contrast-enhanced CT-based radiomic data. Methods By conducting a retrospective analysis involving 242 eligible from 4 centeres, we determined OLM cT SCLC patients. For each lesion, two ROIs were defined gross tumour volume (GTV) 15...
Abstract Cancer stem cells (CSCs) cause tumor metastasis and immune evasion by as-yet-unknown molecular mechanisms. In the present study, we identify a long noncoding RNA (lncRNA), termed PVT1 , which is highly expressed in CSCs correlated closely with lymph node of head neck squamous cell carcinoma (HNSCC). inhibition eliminates CSCs, prevents metastasis, stimulates anti-tumor immunity, while inhibiting HNSCC growth. Moreover, promotes infiltration CD8 + T into microenvironment, thereby...
Histones methyltransferase NSD3 targeting H3K36 is frequently disordered and mutant in various cancers, while the function of during cancer initiation progression remains unclear. In this study, it proved that downregulated level linked to clinical features poor survival lung adenocarcinoma. vivo, inhibited proliferation, immigration, invasion ability Meanwhile, suppressed glycolysis by inhibiting HK2 translation, transcription, glucose uptake, lactate production Mechanistically, as an...
Signaling of RANK (receptor activator nuclear factor kappa B) through its ligand RANKL appears critical in osteolysis associated with aseptic loosening (AL). The purpose this study was to investigate the role a murine model developed knockout (RANK(-/-)) mice. Ultra high molecular weight polyethylene (UHMWPE) debris introduced into established air pouches on RANK(-/-) mice, followed by implantation calvaria bone from syngeneic littermates. Wild type C57BL/6 (RANK(+/+)) mice injected either...
Cisplatin-based chemotherapy is the first-line treatment for late-stage head and neck squamous cell carcinoma (HNSCC). However, resistance to cisplatin has become a major obstacle effective therapy. Cancer stem cells (CSCs) are critical tumor initiation, growth, metastasis, chemoresistance. How effectively eliminate CSCs overcome chemoresistance remains key challenge. Herein, we confirmed that MYC plays roles in chemoresistance, explored targeting preclinical models.
A synthetic strategy for the catalytic asymmetric total synthesis of (+)-strychnine is disclosed. Key features this include an organocatalytic enantioselective Michael addition to establish chirality starting building block, a photoinduced radical cascade reaction access Corynanthe alkaloid intermediate, and bioinspired rearrangement generate core Strychnos alkaloids.
Abstract Up to 20% of patients with total joint arthroplasty will develop radiographic evidence aseptic loosening (AL), which most likely results from an inflammatory response billions wear debris shed the implant. Our previous work has demonstrated that erythromycin (EM), a macrolide antibiotic, inhibits debris‐induced osteoclastogenesis through reduction cytokine production and osteoclast differentiation, both involve NF‐κB pathway. The aim current study was determine whether EM osteolysis...
Interleukin-17A (IL-17A), a proinflammatory cytokine mainly produced by T helper 17 cells, exerts protumor or antitumor effects in different cancer entities. However, the exact role of IL-17A carcinogenesis and progression tongue squamous cell carcinoma (TSCC) remains unclear. Here, we found that levels serum tumor samples were significantly increased TSCC patients positively correlated with metastasis clinical stage. Besides, enhanced migration invasion SCC15, line. Furthermore, inversely...
Asthma is a chronic lung disease characterized by reversible inflammation of the airways. The imbalance Th1/Th2 cells plays significant role in mechanisms asthma. aim this study was to identify asthma-related key genes and functionally enriched pathways Th2-high group using weighted gene coexpression network analysis (WGCNA).The expression profiles GSE4302, which included 42 asthma patients 28 controls, were selected from Gene Expression Omnibus (GEO). A constructed, classified into...
MYC plays critical roles in tumorigenesis and is considered an attractive cancer therapeutic target. Small molecules that directly target are well tolerated vivo represent invaluable anti-cancer agents. Here, we aimed to investigate the effect of inhibitors head neck squamous cell carcinoma (HNSCC). The results showed pharmacological genetic inhibition inhibited HNSCC proliferation migration. inhibitor 975 (MYCi975), growth both line-derived xenograft syngeneic murine models. also induced...
Abstract Lung adenocarcinoma (LUAD) is a fatal threat to human health, while the mechanism remains unclear, and therapy brings limited therapeutic effects. Transcription factor Homeobox C11 (HOXC11) was previously proved be related hind limbs metanephric development during embryonic phase, its role in tumors has been gradually recognized. Our study found that HOXC11 overexpressed LUAD associated with worse overall survival. Moreover, expression lung cancer regulated by IκB kinase α (IKKα),...
Aims White matter damage (WMD) is linked to both cerebral palsy and cognitive deficits in infants born prematurely. The focus of this study was examine how caffeine influences the acetylation proteins within neonatal white evaluate its effectiveness treating caused by hypoxia-ischemia. Main methods We employed a method combining affinity enrichment with advanced liquid chromatography mass spectrometry profile from rats grouped into control (Sham), hypoxic-ischemic (HI), caffeine-treated...
Background Non-specific Orbital Inflammation (NSOI) is a chronic idiopathic condition marked by extensive polymorphic lymphoid infiltration in the orbital area. The integration of metabolic and immune pathways suggests potential therapeutic roles for C-peptide G protein-coupled receptor 146 (GPR146) diabetes its sequelae. However, specific mechanisms through which GPR146 modulates responses remain poorly understood. Furthermore, utility as diagnostic or prognostic marker NSOI has not been...
Objective: To analyze the clinical characteristics of IgG4-related disease (IgG4-RD)so as to improve understanding IgG4-RD in China. Methods: patients were recruited from Peking Union Medical College Hospital between January 2011 and 2016. All followed-up for more than 6 months. The demographic characteristics, symptoms, organ involvements, laboratory examinations treatment efficacy evaluated analyzed. Results: A total 346 finally enrolled, including 230 males (66.5%) 116 females (33.5%)....
Research on the electrical properties of rocks and ores plays a crucial role in development geophysical electromagnetism methods. However, currently available instruments suffer from high power consumption, limited number electrodes, inaccurate measurements, poor portability, ability to measure parameters ores. To address these issues, this paper presents three-dimensional impedance tomography system for rock samples with high-density microelectrodes based an Android STM32 microcontroller....
Gastric cancer (GC) is the third-leading cause of cancer-related deaths. We established a prospective database patients with GC who underwent surgical treatment. In this study, we explored prognostic significance expression CFP1 and 14-3-3 in gastric cancer, by studying specimens collected from clinical subjects.Immunohistochemistry was used to detect 84 subjects, including 73 have undergone radical gastrectomy 11 not surgery. Survival analysis performed km-plot data.According survival...