A5005320241- Bone Tissue Engineering Materials
- Electronic Packaging and Soldering Technologies
- 3D IC and TSV technologies
- Electrospun Nanofibers in Biomedical Applications
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Orthopedic Infections and Treatments
- Advanced Welding Techniques Analysis
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Total Knee Arthroplasty Outcomes
- Copper Interconnects and Reliability
- Dental Implant Techniques and Outcomes
- Additive Manufacturing and 3D Printing Technologies
- Supramolecular Self-Assembly in Materials
- Intermetallics and Advanced Alloy Properties
- Nerve injury and regeneration
- Polydiacetylene-based materials and applications
- Glioma Diagnosis and Treatment
- biodegradable polymer synthesis and properties
- Nerve Injury and Rehabilitation
- RNA Interference and Gene Delivery
- Bone health and treatments
- Surgical site infection prevention
- Bone Metabolism and Diseases
Chongqing University of Science and Technology
2025
Ascension Providence Hospital
2020-2024
Huazhong University of Science and Technology
2013-2024
Tianjin Medical University
2024
Tianjin Medical University Eye Hospital
2024
Union Hospital
2008-2023
Beijing Sanbo Brain Hospital
2009-2023
Capital Medical University
2006-2023
Shenyang University of Technology
2023
Providence Hospital
2020
Chitosan scaffolds appear to be suitable for a variety of tissue engineering applications. This study addressed the biocompatibility chitosan in mouse implantation model. Porous were implanted mice, and animals sacrificed after 1, 2, 4, 8, or 12 weeks. Macroscopic inspection site revealed no pathological inflammatory responses. Histological assessment indicated marked neutrophil accumulation within implant, which resolved with increasing time. Gram staining limulus assays evidence infection...
Diabetic wounds represent a pressing concern affecting the health and quality of life patients. Despite continuous improvement in therapeutic strategy, diabetic remain worldwide challenge. Vascular dysfunction, part due to hyperglycemia, is well-identified factor contributing inadequate healing wounds. In current study, we utilize an extrusion-based cryogenic 3D printing technology construct decellularized small intestinal submucosa (SIS) combined with mesoporous bioactive glass (MBG)...
In situ tissue engineering is a powerful strategy for the treatment of bone defects. It could overcome limitations traditional engineering, which typically involves extensive cell expansion steps, low survival rates upon transplantation, and risk immuno-rejection. Here, porous scaffold polycaprolactone (PCL)/decellularized small intestine submucosa (SIS) was fabricated via cryogenic free-form extrusion, followed by surface modification with aptamer PlGF-2123-144*-fused BMP2 (pBMP2). The two...
Recent innovations in bone tissue engineering have introduced biomaterials that generate oxygen to substitute vasculature. This strategy provides the immediate required for viability and graft maturation. Here we demonstrate a novel oxygen-generating scaffold with predictable release kinetics modular material properties. These hydrogel scaffolds were reinforced microparticles comprised of emulsified calcium peroxide (CaO
The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells. Peripheral endings release neurogenic factors and sense signals, mediate bone metabolism pain. In recent years, tissue engineering has increasingly focused on the effects of nervous system regeneration. Simultaneous regeneration nerves through use materials or by enhancement endogenous repair signals been proven to promote functional Additionally, emerging information mechanisms...
Bioprinting has emerged as a flexible technology in tissue engineering to mimic biological and functional organizational complexity of native tissues. Drop-on-Demand (DoD) bioprinting is one the most promising technologies currently due unique characteristics high-throughput efficiency cost-effectiveness. Despite these significant advantages, DoD some drawbacks, including loss cell viability impacted by shear stress. However, there are only very few studies discussed variation stress...
In the current study, Sr/Fe co-substituted hydroxyapatite (HAp) bioceramics were prepared by sonication-assisted aqueous chemical precipitation method followed sintering at 1100 °C for bone tissue regeneration applications. The sintered analyzed various structural and properties through X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, which confirmed phase purity of HAp co-substitution into its lattice. Vickers hardness measurement, high blood...
Abstract Sequential mineralization enables the integration of minerals within 3D structure hydrogels. Hydrolyzed collagen‐based hydrogels are sequentially mineralized over 10 cycles. One cycle is defined as an incubation period in calcium chloride dihydrate followed by sodium phosphate dibasic dihydrate. Separate cycles completed at 30‐minute and 24‐hour intervals. For gels for 30 min 24 h, compressive moduli increases from 4.25 to 87.57 kPa 125.47 kPa, respectively, number 0 10. As...
Abstract In addition to a biocompatible scaffold and an osteogenic cell population, tissue‐engineered bone requires appropriate vascular bed overcome the obstacle of nutrient oxygen transport in 3D structure. We hypothesized that endothelial cells (ECs) may improve osteogenesis prevent necrosis engineered via effective neovascularization. Osteoblasts ECs were differentiated from marrow BALB/c mice, their phenotypes confirmed prior implantation. Cylindrical porous polycaprolactone...
Photocrosslinked Gelatin–Methacryloyl (GelMA) has been widely used in the field of 3D bioprinting due to its excellent biological properties, but properties are not yet optimized. With advent embedded printing, balance between hydrogel printability and cell viability is expected be achieved. Agarose microgel a good support material because simple preparation, biocompatibility, high melting point, rheology. In this study, aiming at realizing GelMA/Agarose suspension printing system, effect...
Abstract 3D printing of high-strength natural polymer biodegradable hydrogel scaffolds simultaneously resembling the biomechanics corneal tissue and facilitating regeneration remains a huge challenge due to inherent brittleness hydrogels demanding requirements printing. Herein, concentrated aqueous solutions gelatin carbohydrazide-modified alginate (Gel/Alg-CDH) are blended form ink, where hydrazides in Alg-CDH found strong hydrogen bonds with gelatin. The hydrogen-bonding-strengthened...
Printing three-dimensional (3D) scaffolds with suitable mechanical cues is an effective strategy for guiding tissue regeneration by inducing cell migration and growth. Nevertheless, many studies considered only one type of cue 3D engineering scaffold fabrication, such as topological cues, which insufficient. To realize durotaxis- topotaxis-orchestrated guidance on migration, a printed scaffold/hydrogel composite was fabricated in this study. The porous provided (topotaxis), the combined...
Abstract Traditional synthesis methods for metal phosphides are often inefficient and not environmentally friendly due to complex procedures. Here, we propose an eco‐friendly efficient mechanochemical method phosphide flame retardant through high‐energy ball milling. Specifically, solid red phosphorus Ti₃AlC₂ were directly reacted in the milling jar, producing a hybrid with TiP AlP as main active components (TiP/AlP@C). It demonstrates that TiP/AlP@C exhibited excellent performances,...
Abstract Fabricating damage tolerant porous ceramics with efficient energy absorption and impact-resistant capability has been a challenge because of the brittle nature ceramics. In nature, mineralized tissues or organisms such as cuttle bones diatoms have evolved hierarchical pores to overcome this difficulty. A bioinspired design ceramic lattice structure at multiple length-scales, ranging from few nanometers hundreds micrometers, is proposed in present work. These lattices structures were...
Abstract It is recognized that the chronic inflammation in peri‐prosthetic tissue contributes to implant failure frequently provoked by presence of wear debris. Some debris inevitable because nature prosthesis, but not all patients develop severe inflammatory responses. The precise factors mediate severity has yet be fully defined. Because retrieved from consists a heterogeneous mixture materials with various sizes and shapes, this study evaluated influence two major physical aspects...
Abstract Objective Osteoprotegerin (OPG), a natural negative regulator of osteoclastogenesis and bone resorption, may be potential therapeutic agent for treatment osteolysis‐associated prosthetic joint loosening. Using an in vivo adeno‐associated virus (AAV)–mediated gene transfer technique, this study was designed to evaluate the protective effects OPG transgene against orthopedic wear debris–induced loss murine model osteolysis. Methods Bone tissue implanted into established pouches on...