A5008256497- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Automotive and Human Injury Biomechanics
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- Disaster Response and Management
- Electrospun Nanofibers in Biomedical Applications
- Anesthesia and Neurotoxicity Research
- Traumatic Ocular and Foreign Body Injuries
- Nerve Injury and Rehabilitation
- S100 Proteins and Annexins
- Bone Tissue Engineering Materials
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- 3D Printing in Biomedical Research
- Neurogenesis and neuroplasticity mechanisms
- Advanced MRI Techniques and Applications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Advanced Neuroimaging Techniques and Applications
- Veterinary Pharmacology and Anesthesia
- Neuroinflammation and Neurodegeneration Mechanisms
- Cellular Mechanics and Interactions
- Burn Injury Management and Outcomes
Veterans Health Administration
2023-2025
Virginia Tech
2015-2024
Salem VA Medical Center
2015-2024
Mechanics' Institute
2018-2023
Virginia Tech - Wake Forest University School of Biomedical Engineering & Sciences
2014-2023
American Society For Engineering Education
2020
Biomedical Research Institute
2020
Wayne State University
2005-2015
John D. Dingell VA Medical Center
2007-2013
United States Department of Veterans Affairs
2009
Chitosan scaffolds appear to be suitable for a variety of tissue engineering applications. This study addressed the biocompatibility chitosan in mouse implantation model. Porous were implanted mice, and animals sacrificed after 1, 2, 4, 8, or 12 weeks. Macroscopic inspection site revealed no pathological inflammatory responses. Histological assessment indicated marked neutrophil accumulation within implant, which resolved with increasing time. Gram staining limulus assays evidence infection...
The desire to make microfluidic technology more accessible the biological research community has led notion of "modular microfluidics", where users can build a fluidic system using toolkit building blocks. This paper applies modular approach for performing droplet-based screening, including four integral steps library generation, storage, mixing, and optical interrogation. Commercially available cross-junctions are used drop flexible capillary tubing tee-junctions serial mixing. Optical...
Traumatic brain injuries (TBI) caused by improvised explosive devices (IEDs) affect a significant percentage of surviving soldiers wounded in Iraq and Afghanistan. The extent blast TBI, especially initially, is difficult to diagnose, as internal are frequently unrecognized therefore underestimated, yet problems develop over time. Therefore it paramount resolve the physical mechanisms which critical stresses inflicted on tissue from wave encounters with head. This study recorded direct...
Abstract The current study used a rat model to investigate the underlying mechanisms of blast-induced tinnitus, hearing loss, and associated traumatic brain injury (TBI). Seven rats were evaluate behavioral evidence tinnitus TBI using magnetic resonance imaging following single 10-msec blast at 14 psi or 194 dB sound pressure level (SPL). results demonstrated that exposure induced early onset central impairment broad frequency range. tended shift towards high frequencies over time. Hearing...
Mild traumatic brain injury results in aberrant free radical generation, which is associated with oxidative stress, secondary signaling cascades, mitochondrial dysfunction, and poor functional outcome. Pharmacological targeting of radicals antioxidants has been examined as an approach to treatment, but met limited success clinical trials. Conventional that are currently available scavenge a single before they destroyed the process. Here, we report for first time novel regenerative cerium...
Despite the large number of promising neuroprotective agents identified in experimental traumatic brain injury (TBI) studies, none has yet shown meaningful improvements long-term outcome clinical trials. To develop recommendations and guidelines for pre-clinical testing pharmacological or biological therapies TBI, Moody Project Translational Traumatic Brain Injury Research hosted a symposium attended by investigators with extensive experience TBI testing. The participants discussed issues...
Significance We have developed hemostatic nanoparticles that reduce bleeding and increase survival in both the short term long following complex injuries sustained during blast trauma. This treatment has potential to be deployed by first responders save lives.
Abstract In addition to a biocompatible scaffold and an osteogenic cell population, tissue‐engineered bone requires appropriate vascular bed overcome the obstacle of nutrient oxygen transport in 3D structure. We hypothesized that endothelial cells (ECs) may improve osteogenesis prevent necrosis engineered via effective neovascularization. Osteoblasts ECs were differentiated from marrow BALB/c mice, their phenotypes confirmed prior implantation. Cylindrical porous polycaprolactone...
Blast‐induced neurotrauma is a major concern because of the complex expression neuropsychiatric disorders after exposure. Disruptions in neuronal function, proximal time to blast exposure, may eventually contribute late emergence clinical deficits. Using magic angle spinning 1 H MRS and rodent model blast‐induced neurotrauma, we found acute (24–48 h) decreases succinate, glutathione, glutamate, phosphorylethanolamine γ‐aminobutyric acid, no change N ‐acetylaspartate increased...
Few preclinical studies have assessed the long-term neuropathology and behavioral deficits after sustaining blast-induced neurotrauma (BINT). Previous shown extensive astrogliosis cell death at acute stages (<7 days) but temporal response a chronic stage has yet to be ascertained. Here, we used assays, immmunohistochemistry neurochemistry in limbic areas such as amygdala (Amy), Hippocampus (Hipp), nucleus accumbens (Nac), prefrontal cortex (PFC), determine effects of single blast exposure....
Mild blast-induced traumatic brain injury (bTBI) is a modality of that has been major concern considering large number military personnel exposed to explosive blast waves. bTBI results from the propagation high-pressure static forces and their subsequent energy transmission within tissue. Exposure this overpressure causes diffuse leads acute cell damage and, if chronic, detrimental long-term cognitive deficits. The literature presents neuro-centric approach role mitochondria dynamics...
This is a protocol to describe the materials and methods utilized perform splash test for assessment of grooming behaviors as measure self-care in adult rats. The uses an atomized spray bottle coat animal’s back fur 10% sucrose solution before being placed into small testing box observation behaviors. Alterations total time spent grooming, frequency bouts, or latency begin may suggest depression-like behavior compulsive-like behavior, depending on directionality behavioral alterations....
Stress is a common occurrence for military personnel. This can include the stress of deployment and active combat. Anxiety considered reaction to with anxiety related disorders on rise, it imperative that be pre-existing condition when studying number neurological conditions. To determine effects behavioral outcomes traumatic brain injury (TBI), we used 3-day acute unpredictable (AUS) model followed by blast induce neurotrauma (BINT) assessed social anhedonia anxiety-like behaviors in male...