A5101458316- Automotive and Human Injury Biomechanics
- Occupational and environmental lung diseases
- Cancer survivorship and care
- Traumatic Brain Injury and Neurovascular Disturbances
- Head and Neck Cancer Studies
- Fibroblast Growth Factor Research
- Acute Myeloid Leukemia Research
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Systems, Economic Evaluations, Quality of Life
- Tissue Engineering and Regenerative Medicine
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Spaceflight effects on biology
- Global Cancer Incidence and Screening
- Lung Cancer Treatments and Mutations
- Cancer-related cognitive impairment studies
- Traumatic Brain Injury Research
- Family Support in Illness
- Immune Cell Function and Interaction
- Transportation Safety and Impact Analysis
University of Veterinary Medicine Vienna
2019-2024
University Medical Center Hamburg-Eppendorf
2013-2024
Universität Hamburg
2013-2024
Takeda (Austria)
2022-2024
Comprehensive Cancer Center Vienna
2014-2023
Medical University of Vienna
2014-2023
IMC University of Applied Sciences Krems
2021-2022
Applied Research Associates (United States)
2021
Vienna General Hospital
2020
Instituto de Física Teórica
2018
Adeno-associated viruses (AAV) are one of the most commonly used vehicles in gene therapies for treatment rare diseases. During AAV manufacturing process, particles with little or no genetic material co-produced alongside desired capsid containing transgene interest. Because potential adverse health effects these byproducts, they considered impurities and need to be monitored carefully. To date, analytical ultracentrifugation (AUC), transmission electron microscopy (TEM) charge-detection...
Malignant pleural mesothelioma is an aggressive malignancy characterized by frequent resistance to chemo- and radiotherapy, poor outcome, limited therapeutic options. Fibroblast growth factors (FGFs) their receptors are potential targets for cancer therapy, but significance in has remained largely undefined.To investigate the antimesothelioma of FGF receptor 1 (FGFR1) inhibition.Expression FGFs was analyzed cell lines tissue specimens. Several models were used FGFR1 inhibition vitro...
Malignant pleural mesothelioma (MPM), an aggressive malignancy affecting surfaces, occurs in three main histological subtypes. The epithelioid and sarcomatoid subtypes are characterized by cuboid fibroblastoid cells, respectively. biphasic subtype contains a mixture of both. expresses markers epithelial-mesenchymal transition (EMT) confers the worst prognosis, but signals pathways controlling EMT MPM not well understood. We demonstrate that treatment with FGF2 or EGF induced morphology...
As early as the 1950's, Gurdjian and colleagues (Gurdjian et al. 1955) observed that brain injuries could occur by direct pressure loading without any global head accelerations. This pressure-induced injury mechanism was "forgotten" for some time is being rekindled due to many mild traumatic attributed blast overpressure. The aim of current study develop a finite element (FE) model predict biomechanical response rat under shock tube environment. model, including more than 530,000 hexahedral...
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive immature cancer. Mutations in IL7R have been analyzed genetically, but downstream effector functions such as STAT5A and STAT5B hyperactivation are poorly understood. Here, we studied the most frequent clinically challenging STAT5BN642H driver development cancer onset compared it with hyperactive variants transgenic mice. Enhanced STAT5 activity caused disrupted promoted early progenitor-ALL phenotype, upregulation of genes involved...
Thoracic injury in the paediatric population is a relatively common cause of severe and has an accompanying high mortality rate. However, no anatomically accurate, complex chest finite element (FE) component model available for 10-year old published literature. In this study, 10-year-old thorax FE was developed based on internal external geometries segmented from medical images. The then validated against data measured during cardiopulmonary resuscitation performed subjects.
Ion-exchange chromatography coupled to light scattering detectors represents a fast and simple analytical method for the assessment of multiple critical quality attributes (CQA) in one single measurement. The determination CQAs play crucial role Adeno-Associated Virus (AAV)-based gene therapies their applications humans. Today, several different techniques, including size-exclusion (SEC), ultracentrifugation (AUC), qPCR or ELISA, are commonly used characterize therapy product regarding...
Taxane-based checkpoint inhibitor combination therapy might improve the outcome in recurrent/metastatic (R/M) head and neck cancer (HNSCC) patients. Thus, we investigated efficacy safety of docetaxel (DTX) plus pembrolizumab (P) a prospective phase I/II trial.Platinum-resistant R/M HNSCC patients received DTX 75 mg/m^2 P 200 mg for up to six cycles followed by maintenance therapy. The primary endpoint was overall response rate (ORR) safety. Secondary endpoints comprised disease control...
Mass photometry (MP) is a fast and simple analysis method for the determination of proportions subpopulations in an AAV sample. It label-free requires minimal sample volumes between 5-10 µL, which makes it promising candidate over orthogonal techniques such as analytical ultracentrifugation (AUC), cryo-transmission electron microscopy (Cryo-TEM) or charge-detection mass spectrometry (CDMS). However, these methods are limited their application to purified samples only. Here we developed...
Pembrolizumab alone or combined with chemotherapy is now approved in PD-L1-positive patients recurrent metastatic squamous cell carcinoma of the head and neck (SCCHN). Since real-world data are pending, our goal was to evaluate efficacy safety immune checkpoint inhibitor (CPI) therapy an unselected cohort SCCHN.We analyzed 78 SCCHN from three Austrian cancer centers that received CPI as palliative first-line systemic treatment for this retrospective study. Patient characteristics, details on...
Population ageing leads to a noticeable increase in demand for informal care. Informal caregivers experience high caregiver burden, such as restricted subjective health and well-being. Occupational balance is associated with However, associations between occupational well-being of older persons have not been investigated yet. Thus, the objective this study was explore persons.
Development of advanced computational rat head models requires accurate material properties the brain, meninges, skull, and other soft tissues. This study investigated adult skull properties, which are very limited in current literature. A total 20 specimens were harvested from 10 rats. High resolution (16 μm) microcomputed tomography scans performed for each specimen to observe dimensional changes within internal porosities through cross sections. The tested three-point bending at loading...
We analyzed the levels of selected micro-RNAs in normal prostate tissue to assess their potential indicate tumor foci elsewhere prostate. Histologically samples from 31 cancer patients and two negative control groups with either unsuspicious or elevated specific antigen (PSA) (14 17 individuals, respectively) were analyzed. Based on expression analysis 157 microRNAs a pool information data bases/literature, we eight for quantification by real-time polymerase chain reactions (RT-PCRs)....
Background: Nasopharyngeal carcinoma (NPC) is endemic in East Asia but rare the western world. Programmed death ligand 1 (PD-L1) expression on NPC correlates with clinical outcomes. However, data for Caucasian patients are missing. Thus, we performed this retrospective analysis investigating potential association of immune checkpoint protein outcome parameters patients. Methods: Fifty-five treated between 1993 and 2018 at Medical University Vienna were identified. After exclusion Asian...
Background: Constructing meaning in cancer leads to improved psychosocial outcomes for patients and survivors. Aim: We tested the feasibility preliminary efficacy of a meaning-based intervention couples. Design: The single-arm pilot study 4-session, tailored, activities-based couple’s intervention. Setting/Participants: Twelve adults with incurable their partners participated either university office or at home. Results: showed good feasibility. One two depressed baseline was no longer...
Objectives Informal caregivers often experience a restriction in occupational balance. The self-reported questionnaire on Occupational Balance Caregivers (OBI-Care) is measurement instrument to assess balance informal caregivers. Measurement properties of the German version OBI-Care had previously been assessed parents preterm infants exclusively. Thus, aim this study was examine mixed population Methods A psychometric conducted, applying multicenter cross-sectional design. (construct...
We investigated the influence of population-wide COVID-19 lockdown measures implemented on 16, March 2020 routine and emergency care cancer outpatients at a tertiary centre in Vienna, Austria.We compared number/visits receiving oncological therapies oncologic day clinic (DC) admissions department (ED) our institution time periods before (pre-lockdown period: 1 January - 15 2020) after (post-lockdown 16 March- 31 May implementation with respective reference 2018 2019. Additionally, we...
Cancer illness representations and screening history among residents of Kolkata, India, were investigated along with socio-demographic characteristics in an effort to understand possible motivations for health behavior. A total 106 participants recruited from community locations India completed surveys including demographics, the perception questionnaire-revised (IPQ-R), previous experience cancer practices. Participants 51.5% college educated, 57% female, full-time employed average age 32.7...