A5036798732- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- EEG and Brain-Computer Interfaces
- Advanced Memory and Neural Computing
- Conducting polymers and applications
- 3D Printing in Biomedical Research
- Electrochemical Analysis and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Neural dynamics and brain function
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury Research
- Vagus Nerve Stimulation Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrochemical sensors and biosensors
- Mitochondrial Function and Pathology
- Muscle activation and electromyography studies
- Photoreceptor and optogenetics research
- RNA Interference and Gene Delivery
- Cardiac Arrest and Resuscitation
- Analytical Chemistry and Sensors
- Neurological disorders and treatments
- Pain Mechanisms and Treatments
- Alcoholism and Thiamine Deficiency
- Poisoning and overdose treatments
University of Michigan–Ann Arbor
2019-2024
Louis Stokes Cleveland VA Medical Center
2017-2023
VA Ann Arbor Healthcare System
2019-2023
Michigan United
2023
Case Western Reserve University
2017-2022
University School
2017
Virginia Tech
2014-2015
Wayne State University
2008-2013
Clinical implantation of intracortical microelectrodes has been hindered, at least in part, by the perpetual inflammatory response occurring after device implantation. The neuroinflammatory observed correlated to oxidative stress that occurs due neurological injury and disease. However, there yet be a definitive link microelectrode Thus, objective this study is give direct evidence following This also aims identify potential molecular targets attenuate post-implantation. Here, we implanted...
The desire to make microfluidic technology more accessible the biological research community has led notion of "modular microfluidics", where users can build a fluidic system using toolkit building blocks. This paper applies modular approach for performing droplet-based screening, including four integral steps library generation, storage, mixing, and optical interrogation. Commercially available cross-junctions are used drop flexible capillary tubing tee-junctions serial mixing. Optical...
Intracortical microelectrodes have shown great success in enabling locked-in patients to interact with computers, robotic limbs, and their own electrically driven limbs. The recent advances inspired world-wide enthusiasm resulting billions of dollars invested federal industrial sponsorships understanding the brain for rehabilitative applications. Additionally, private philanthropists also demonstrated excitement field by investing use interfacing technologies as a means human augmentation....
Intracortical microelectrodes are a critical component of brain-machine interface (BMI) systems. The recording performance intracortical used for both basic neuroscience research and clinical applications BMIs decreases over time, limiting the utility devices. neuroinflammatory response to microelectrode has been identified as significant contributing factor its performance. Traditionally, pathological assessment limited dozen or so known proteins, only few groups have begun explore changes...
Abstract The smooth surface structure of intracortical microelectrodes implanted within the nanometer‐scale architecture brain tissue may contribute to foreign body response. Here, neuroinflammatory response nanopatterning grooves etched directly on nonfunctional Michigan‐style is explored. Rats with nanopatterned silicon are compared control implants observe effects have neuroinflammation. Histology and real‐time PCR at 2 4 weeks postimplantation quantify glial cell reactivity activation,...
Abstract An array of design strategies have been targeted toward minimizing failure implanted microelectrodes by the chronic glial scar around microelectrode under conditions. Current approaches inhibiting initiation scarring range from altering geometry, roughness, size, shape, and materials device. Studies shown which mimic nanotopography natural environment in vivo will consequently result an improved biocompatible response. Nanofabrication electrode arrays is being pursued field neuronal...
Neuroinflammatory mechanisms are hypothesized to contribute intracortical microelectrode failures. The cluster of differentiation 14 (CD14) molecule is an innate immunity receptor involved in the recognition pathogens and tissue damage promote inflammation. goal study was investigate effect CD14 inhibition on recording performance integration.Mice implanted with microelectrodes motor cortex underwent electrophysiological characterization for 16 weeks, followed by endpoint histology. Three...
Intracortical microelectrodes are used with brain-computer interfaces to restore lost limb function following nervous system injury. While promising, recording ability of intracortical diminishes over time due, in part, neuroinflammation. As curcumin has demonstrated neuroprotection through anti-inflammatory activity, we fabricated a 300 nm-thick microelectrode coating consisting polyurethane copolymer and polyethylene glycol (PEG), denoted as poly(curcumin-PEG
Intracortical microelectrodes are valuable tools used to study and treat neurological diseases. Due in large part the oxidative stress inflammatory response occurring after electrode implantation, signal quality of these electrodes decreases over time. To alleviate this response, resveratrol, a natural antioxidant which elicits neuroprotective effects through reduction stress, was utilized. This work compares traditional systemic delivery resveratrol novel cyclodextrin polymer (pCD) local...
Neural electrode devices hold great promise to help people with the restoration of lost functions. However, research is lacking in biomaterial design a stable, long-term device. Glial scarring initiated when device inserted into brain tissue and an inflammatory response ensues. Astrocytes become hypertrophic, hyperplastic, upregulate glial-fibrillary acidic protein. This study was designed investigate astrocyte proliferation, viability, morphology, gene expression assess reactive state cells...
Controlled expression of glial cell line derived neurotrophic factor (Gdnf) can be integrated in the development a system for repair injured peripheral nerves. This delivery strategy was demonstrated via inducible Gdnf from microencapsulated cells barium alginate. The Schwann RT4-D6P2T initially modified utilizing an ecdysone-based stable transfection to produce RT4-Gdnf cells. During construct preparation, it found that C6 (where cDNA isolated) make three transcript variants. Additionally,...
Microdroplet systems can drastically reduce costs and increase throughput in high screening (HTS) assays. While droplets are well suited for biomolecular screening, cell-based screens more problematic because eukaryotes typically require attachment to solid supports maintain viability function. This paper describes an economical, off-the-shelf microfluidic system which encapsulates eukaryotic cells gelatinous alginate capsules the purpose of HTS. The flow-through consists i) a cross...
Progress has been made in the field of neural interfacing using both mouse and rat models, yet standardization these models’ interchangeability to be established. The model allows for transgenic, optogenetic, advanced imaging modalities which can used examine biological impact failure mechanisms associated with implant itself. ability directly compare electrophysiological data between models is crucial development assessment interfaces. most obvious difference two rodent size, raises concern...
(1) Background: Intracortical microelectrodes (IMEs) are an important part of interfacing with the central nervous system (CNS) and recording neural signals. However, electrodes have shown a characteristic steady decline in performance owing to chronic neuroinflammation. The topography implanted devices has been explored mimic nanoscale three-dimensional architecture extracellular matrix. Our previous work used histology study implant sites non-recording probes showed that at probe surface...
Endocrine disorders have been shown to be a consequence of blast traumatic brain injury in soldiers returning from military conflicts. Hormone deficiency and adrenocorticotropic hormone (ACTH) dysfunction can lead symptoms such as fatigue, anxiety, irritability, insomnia, sexual dysfunction, decreased quality life. Given these changes following exposure, the current study focused on investigating chronic pathology within hypothalamus blast, addition systemic effects. An established rodent...
With advances in electronics and fabrication technology, intracortical microelectrodes have undergone substantial improvements enabling the production of sophisticated with greater resolution expanded capabilities. The progress technology has supported development biomimetic electrodes, which aim to seamlessly integrate into brain parenchyma, reduce neuroinflammatory response observed after electrode insertion improve quality longevity electrophysiological recordings. Here we describe a...
(1) Background: Intracortical microelectrodes (IMEs) are essential to basic brain research and clinical brain-machine interfacing applications. However, the foreign body response IMEs results in chronic inflammation an increase levels of reactive oxygen nitrogen species (ROS/RNS). The current study builds on our previous work, by testing a new delivery method promising antioxidant as means extending intracortical performance. While resveratrol has shown efficacy improving tissue response,...
Medical devices implanted in the brain hold tremendous potential. As part of a Brain Machine Interface (BMI) system, intracortical microelectrodes demonstrate ability to record action potentials from individual or small groups neurons. Such recorded signals have successfully been used allow patients interface with control computers, robotic limbs, and their own limbs. However, previous animal studies shown that microelectrode implantation not only damages surrounding tissue but can also...
(1) Background: Intracortical microelectrodes (IMEs) are an important part of interfacing with the central nervous system (CNS) and recording neural signals. However, electrodes have shown a characteristic steady decline in performance owing to chronic neuroinflammation. The topography implanted devices has been explored mimic nanoscale three-dimensional architecture extracellular matrix. Our previous work used histology study implant sites non-recording probes showed that at probe surface...