A5101758017- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Conducting polymers and applications
- Advanced Memory and Neural Computing
- Nanoparticle-Based Drug Delivery
- Photoreceptor and optogenetics research
- Vagus Nerve Stimulation Research
- Neural dynamics and brain function
- Nanoplatforms for cancer theranostics
- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Analytical Chemistry and Sensors
- Platelet Disorders and Treatments
- 3D Printing in Biomedical Research
Case Western Reserve University
2018-2024
Louis Stokes Cleveland VA Medical Center
2018-2023
Treatment of bleeding disorders using transfusion donor-derived platelets faces logistical challenges due to their limited availability, high risk contamination, and short (5 7 days) shelf life. These could be potentially addressed by designing platelet mimetics that emulate the adhesion, aggregation, procoagulant functions platelets. To this end, we created liposome-based platelet-mimicking nanoparticles (PPNs) can expose phospholipid phosphatidylserine on surface in response plasmin....
Progress has been made in the field of neural interfacing using both mouse and rat models, yet standardization these models’ interchangeability to be established. The model allows for transgenic, optogenetic, advanced imaging modalities which can used examine biological impact failure mechanisms associated with implant itself. ability directly compare electrophysiological data between models is crucial development assessment interfaces. most obvious difference two rodent size, raises concern...
Abstract Intracortical microelectrodes (IMEs) can be used to restore motor and sensory function as a part of brain–computer interfaces in individuals with neuromusculoskeletal disorders. However, the neuroinflammatory response IMEs result their premature failure, leading reduced therapeutic efficacy. Mechanically-adaptive, resveratrol-eluting (MARE) neural probes target two mechanisms believed contribute by reducing mechanical mismatch between brain tissue device, well locally delivering an...
This study explores the challenges associated with nanoparticle-based drug delivery to tumor parenchyma, focusing on widely utilized enhanced permeability and retention effect (EPR). While EPR has been a key strategy, its inconsistent clinical success lacks clear mechanistic understanding is hindered by limited tools for studying relevant phenomena. work introduces an approach that employs multiparametric dynamic contrast-enhanced ultrasound (CEUS) nanoscale contrast agent noninvasive,...
Intracortical neural probes are both a powerful tool in basic neuroscience studies of brain function and critical component computer interfaces (BCIs) designed to restore paralyzed patients. can be used detect activity at single unit resolution stimulate small populations neurons with high resolution. Unfortunately, intracortical tend fail chronic timepoints large part due the neuroinflammatory response that follows implantation persistent dwelling cortex. Many promising approaches under...
(1) Background: Intracortical microelectrodes (IMEs) are essential to basic brain research and clinical brain-machine interfacing applications. However, the foreign body response IMEs results in chronic inflammation an increase levels of reactive oxygen nitrogen species (ROS/RNS). The current study builds on our previous work, by testing a new delivery method promising antioxidant as means extending intracortical performance. While resveratrol has shown efficacy improving tissue response,...
Introduction: Intracortical microelectrodes (IME) are vital to properly functioning brain-computer interfacing (BCI). However, the recording electrodes have shown a steady decline in performance after implantation, mainly due chronic inflammation. Compliant materials been explored decrease differential strain resulting lower neural We previously developed fabrication method for creating mechanically adaptive microfluidic probes made of cellulose nanocrystal (CNC) polymer nanocomposite...
The tumor microenvironment is characterized by dysfunctional endothelial cells, resulting in heightened vascular permeability. Many nanoparticle-based drug delivery systems attempt to use this enhanced permeability combined with impaired lymphatic drainage (a concept known as the 'enhanced and retention effect' or EPR effect) primary strategy for delivery, but has not proven be clinically effective anticipated. specific mechanisms behind inconsistent clinical outcomes of nanotherapeutics...
<title>Abstract</title> Intracortical microelectrodes are used for recording activity from individual neurons, providing both a valuable neuroscience tool and an enabling medical technology individuals with motor disabilities. Standard neural probes carrying the rigid silicon-based structures that can penetrate brain parenchyma to interface targeted neurons. Unfortunately, within weeks after implantation into brain, quality degrades, owing largely neuroinflammatory response. Key contributors...
Long-term reliability of intracortical microelectrodes remains a challenge for increased acceptance and deployment. There are conflicting reports comparing measurements associated with recording quality postmortem histology, in attempts to better understand failure (IMEs). Our group has recently introduced the assessment motor behavior tasks as another metric evaluate effects IME implantation. We hypothesized that adding third dimension our analysis, functional testing, could provide...
Microfluidic intracortical neural probes were developed using a mechanically-adaptive polymer nanocomposite. Three different microfluidic channel fabrication methods explored: Emboss-only, Mold-only, and hybrid Mold/Emboss method. Films produced from each method inspected characterized microscopy profilometry. Further, we studied the ability of approach to produce with functional channels. The results indicate that had highest fidelity transfer pattern nanocomposite was most successful in...