A5088445823- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Conducting polymers and applications
- Virus-based gene therapy research
- Photoreceptor and optogenetics research
- Advanced Memory and Neural Computing
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
Case Western Reserve University
2021
Louis Stokes Cleveland VA Medical Center
2021
(1) Background: Intracortical microelectrodes (IMEs) are essential to basic brain research and clinical brain-machine interfacing applications. However, the foreign body response IMEs results in chronic inflammation an increase levels of reactive oxygen nitrogen species (ROS/RNS). The current study builds on our previous work, by testing a new delivery method promising antioxidant as means extending intracortical performance. While resveratrol has shown efficacy improving tissue response,...
Microfluidic intracortical neural probes were developed using a mechanically-adaptive polymer nanocomposite. Three different microfluidic channel fabrication methods explored: Emboss-only, Mold-only, and hybrid Mold/Emboss method. Films produced from each method inspected characterized microscopy profilometry. Further, we studied the ability of approach to produce with functional channels. The results indicate that had highest fidelity transfer pattern nanocomposite was most successful in...