A5016079502- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Spine and Intervertebral Disc Pathology
- Total Knee Arthroplasty Outcomes
- Bone Metabolism and Diseases
- Tissue Engineering and Regenerative Medicine
- Nanoparticle-Based Drug Delivery
- Musculoskeletal pain and rehabilitation
- RNA Interference and Gene Delivery
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Atrial Fibrillation Management and Outcomes
- Immunotherapy and Immune Responses
- Graphene and Nanomaterials Applications
- Mesenchymal stem cell research
- Shoulder Injury and Treatment
- Virus-based gene therapy research
- Tendon Structure and Treatment
- Pluripotent Stem Cells Research
- Angiogenesis and VEGF in Cancer
- Wound Healing and Treatments
Wichita State University
2016-2025
University of Kansas
2016-2025
Min-Hwei College of Health Care Management
2025
Ministry of Health and Welfare
2008-2025
Yonsei University Health System
2021-2023
National Sun Yat-sen University
2020-2023
Wichita Clinic
2020-2023
Yonsei University
2023
Via Christi Hospital
2013-2022
Korea University of Technology and Education
2022
To evaluate patient outcome and investigate the prognostic factors of high-grade meningiomas by adopting 2000 World Health Organization (WHO) classification system.Between 1986 2004, 74 patients were diagnosed with meningioma: 33 atypical 41 anaplastic meningioma. The mean follow-up was 58.5 months. We reclassified all surgical specimens, according to WHO system, using two expert neuropathologists.Forty as meningioma 24 Overall recurrence-free survivals significantly longer in than those...
Understanding growth regulation in hormone-refractory prostate cancer may provide avenues for novel treatment interventions. This study was conducted to characterize the expression of receptor (FSHR) follicle-stimulating hormone (FSH) androgen-independent cell lines and human malignant tissues.Western blotting, immunohistochemistry (IHC), flow cytometric analysis were used FSHR. The effect FSH on clonogenicity studied using proliferation clonogenic assays.Immunohistochemistry revealed PC3...
Low back pain (LBP) is one of the top three causes disability in developed countries, and intervertebral disc degeneration (IDD) a major contributor to LBP. In process IDD, there gradual decrease nucleus pulposus cells (NPCs) extracellular matrix (ECM). Exosomes are important exocrine mediators stem that can act directly on for tissue repair regeneration. this study, we determined antisenescence, cell proliferation promotion, ECM modulation effects human urine-derived (USC) exosomes...
Objective. This study is aimed at determining the effects of human urine-derived stem cell-derived exosomes (USCs-exos) on pressure-induced nucleus pulposus cell (NPC) apoptosis and intervertebral disc degeneration (IDD) ERK AKT signaling pathways. Methods. The NPCs were obtained from patients with herniated lumbar discs. Western blot analysis (WB) quantitative real-time polymerase chain reaction (qRT-PCR) used to determine endoplasmic reticulum (ER) stress levels under stress. Human USCs...
Abstract The influence of variant pore‐size and porosity on the microstructure mechanical properties poly‐ε‐caprolactone (PCL) hydroxyapatite (HA) composite were examined for an optimal scaffold in bone tissue engineering. Three various amounts sodium chloride (NaCl, as porogens) with two distinct particle size ranges (212–355 μm 355–600 μm) blended into PCL HA mixture, followed by a leaching technique to generate PCL‐HA scaffolds pores porosity. porosities correlated porogen concentration....
Abstract In addition to a biocompatible scaffold and an osteogenic cell population, tissue‐engineered bone requires appropriate vascular bed overcome the obstacle of nutrient oxygen transport in 3D structure. We hypothesized that endothelial cells (ECs) may improve osteogenesis prevent necrosis engineered via effective neovascularization. Osteoblasts ECs were differentiated from marrow BALB/c mice, their phenotypes confirmed prior implantation. Cylindrical porous polycaprolactone...
It remains unclear how the expression of microRNAs (miRNAs) in human periodontal ligament stem cells (PDLSCs) might respond to mechanical stretch. To investigate specific miRNA stretched PDLSCs, we used a Flexcell® FX-5000™ tension system achieve external stimulation. Then, custom-designed microarray assay was performed and describe genome-wide differential miRNAs normal PDLSCs. Finally, implemented integrative target prediction network analysis approaches construct an interaction key their...
Adjuvant chemotherapy is a critical regime in cancer treatment. The Magnetic Targeted Drug Delivery System (MTDDS) can selectively aggregate agents at the target areas, which has attracted high attention due to its safety, efficiency, and minimal side effects human body. It would be ideal establish tissue engineering scaffold that not only reconstruct defect from surgical tumor removal, but also serve as magnetic station attract MTDDS local site enhance targeted drug delivery. current study...
University students frequently encounter stress and anxiety, impacting their autonomic nervous system mental health. Rhythmic photic stimulation (RPS) at various frequencies is considered a potential intervention for anxiety depression, but its effectiveness not fully understood. This research aimed to assess the impact of RPS theta (6 Hz), alpha (10 beta (25 Hz) on regulation in university students, comparing effects between those with without depression symptoms. Conducted southern Taiwan...
Adjuvant chemotherapy is a critical regime in cancer treatment. The magnetic targeted drug delivery system (MTDDS) can selectively aggregate agents at the target areas, which has attracted great attention due to its safety, high efficiency, and minimal side effects on human body. It would be ideal establish tissue engineering scaffold that not only reconstruct defect from surgical tumor removal, but also serve as station attract MTDDS local site enhance delivery. current study constructed...
Abstract Objective Osteoprotegerin (OPG), a natural negative regulator of osteoclastogenesis and bone resorption, may be potential therapeutic agent for treatment osteolysis‐associated prosthetic joint loosening. Using an in vivo adeno‐associated virus (AAV)–mediated gene transfer technique, this study was designed to evaluate the protective effects OPG transgene against orthopedic wear debris–induced loss murine model osteolysis. Methods Bone tissue implanted into established pouches on...
Abstract We examined a novel mouse model of wear debris‐induced prosthesis instability and osteolysis, its application for the evaluation therapy. A stainless steel or titanium‐alloy pin was implanted into proximal tibia to form contiguous surface with articular cartilage. In some mice, titanium particles were injected tibial canal during surgery, followed by monthly intraarticular injection. MicroCT scans revealed that implants without particle challenge stable bone mineral density changes...
Background The aim of this study was to analyse the trends mortality and causes death among HIV‐infected patients in Taiwan from 1984 2005. Methods Registered data certificates for Centers Disease Control were reviewed. Mortality rate deaths compared whose HIV diagnosis made three different periods: before introduction highly active antiretroviral therapy (HAART) (pre‐HAART: 1 January 31 March 1997), early HAART period (from April 1997 December 2001), late 2002 2005). A subgroup 1161 (11.4%)...