As people age, degenerative bone and joint diseases (DBJDs) become more prevalent. When middle-aged elderly are diagnosed with one or disorders such as osteoporosis (OP), osteoarthritis (OA), intervertebral disc degeneration (IVDD), it often signals the onset of prolonged pain reduced functionality. Chronic inflammation has been identified underlying cause various diseases, including DBJDs. Recently, excessive activation pyroptosis, a form programed cell death (PCD) mediated by...

Background:The method of action Bushen Formula (BSHXF) in the treatment intervertebral disc degeneration (IVDD) was uncovered this work using vivo and vitro tests.To clarify mechanism BSHXF, we validated rat model nucleus pulposus cell model. Methods:In an IVDD study explores impact BSHXF on mitochondrial function, pro-inflammatory cytokines, pro-apoptotic factors, matrix metalloproteinases.Additionally, it evaluates induced (NP) cells stimulated by interleukin-1 β (IL-1β).The measures...

Activation of the proinflammatory-associated cytokine, tumor necrosis factor-α (TNF-α), in nucleus pulposus (NP) cells is essential for pathogenesis intervertebral disc degeneration (IDD). Restoring autophagic flux has been shown to effectively protect against IDD and a potential target treatment. The goal this study was explore particular signalings responsible protective effects naringin, known autophagy activator, on human NP cells. results showed that significantly increased observed...

Steroid-induced osteonecrosis of the femoral head (SONFH) was a refractory orthopedic hip joint disease in young and middle-aged people, but pathogenesis SONFH remained unclear. We aimed to identify potential genes screen therapeutic compounds for SONFH.The microarray obtained blood tissue from GEO database, then it identifies differentially expressed (DEGs). The DEGs were analyzed obtain differences immune cell infiltration. gene functional enrichment analysis analyzed. PPI identified...

Abstract Background The interbody fusion apparatus is a key component of the operation and plays role in postoperative efficacy. Cage subsidence one common complications after lumbar internal fixation. Clinical studies on risk factors cage are incomplete inaccurate, especially paravertebral muscle atrophy intervertebral bone time. Methods Among patients who underwent PLIF surgery our hospital from January 2016 to 2019, 30 with without were randomly selected be included this study....

Abstract: Wear debris associated periprosthetic osteolysis represents a major pathological process with the aseptic loosening of joint prostheses. Naringin is flavonoid identified in grapefruit. Studies have shown that naringin possesses many pharmacological properties including effects on bone metabolism. The current study evaluated influence wear induced osteoclastic resorption both vitro and vivo. osteoclast precursor cell line RAW 264.7 was cultured stimulated polymethylmethacrylate...

Posterior percutaneous long-segment internal fixation and open with screws have been used to treat thoracolumbar fractures in ankylosing spondylitis patients.To observe the clinical effect of posterior 26 (AS) patients fractures.Retrospective cohort study.Forty-seven AS who were diagnosed treated from December 2014 2018.Visual analog scale score, Cobb angle, American Spinal Injury Association Grade, SF-Qualiveen pedicle screw misplacement rate, operative duration, blood loss, complications,...

Background: Similar pathogenesis makes Corona Virus Disease 2019 (COVID-19) associated with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and gouty (GA), it is possible to introduce common drugs for the treatment of RA, AS GA into COVID-19. That is, "homotherapy heteropathy", especially cytokine inhibitors. But little known about specific link between diseases. In addition, "new use old drugs" an important short-term strategy Cepharanthine (CEP), a monomer component traditional...

Objective To explore the safety and efficacy of percutaneous pedicle screw fixation combined with vertebroplasty for treatment stage III Kümmell disease. Methods The clinical data follow‐up results 22 patients disease who were admitted to our department from 2014 2018 analyzed. There 14 females eight males, Age range was 58–81 years. All followed up 24 months. method vertebroplasty. patient general information such as age, gender, bedrest time location fracture vertebrae recorded. symptoms...

This study aimed to develop and validate a new nomogram model that can predict vertebral fractures after surgery for osteoporotic compression optimize surgical plans reduce the incidence of fractures. 420 patients with were randomly sampled using computer at fixed ratio; 80% assigned training set, while remaining 20% validation set. The least absolute shrinkage selection operator (LASSO) regression method was applied screen factors influencing refracture construct predictive multivariate...

Osteoarthritis (OA) is the most prevalent type of arthritis and main reason for progressive disability in middle-aged older people. Studies candidate genes may provide a novel insight treatment strategy knee osteoarthritis (KOA). The aim this study was to investigate relationship between KOA susceptibility single-nucleotide polymorphism (SNP) ADAMTS-5 gene. case group included 188 patients from Luoyang Orthopedic Hospital with clinically radiographically diagnosed primary KOA, control 100...

Background: Quinazolines are an important class of benzopyrimidine heterocyclic compounds with a promising antitumor activity that can be used for the design and development osteosarcoma target compounds. Objective: To predict compound quinazoline by constructing 2D- 3D-QSAR models, to new according main influencing factors in two models. Methods: First, heuristic method GEP (gene expression programming) algorithm were construct linear non-linear 2D-QSAR Then model was constructed using...

Abstract Background Those pelvic parameters of sacral slope (SS) and tilt (PT) correlated significantly to lumbar spine hip joints respectively. We proposed the match between SS PT, namely spinopelvic index (SPI), in order investigate whether SPI proximal junctional failure (PJF) adult spinal deformity (ASD) after correction surgery. Methods Ninety-nine ASD patients who had undergone long-fusion (≥ 5 vertebras) surgeries were reviewed retrospectively two medical institutions from January...

To determine the effects of Bushenhuoxue formula (BHF) on interleukin-1 beta (IL-1β), transforming growth factor 1 (TGF-β1), discoidin domain receptor 2 (DDR2) and matrix metalloproteinase-1 (MMP-1) levels in a rat model osteoarthritis (OA). Sprague-Dawley rats were used to establish an OA subjected various treatments over 6 weeks. Rats treated with BHF, glucosamine sulfate (GS), or starch as control. Serum IL-1β MMP-1 joint fluid determined by means ELISAs. We immunohistochemistry DDR2 knee...

Background. Low back pain (LBP) has the characteristics of chronic and persistence, which is a heavy social burden. Intervertebral disc degeneration (IVDD) major cause LBP. The typical features IVDD are extracellular matrix (ECM) degradation nucleus pulposus cell (NP) apoptosis. Bushen Huoxue Formula (BSHXF) good clinical effects on However, mechanism BSHXF affecting ECM NP cells still unclear. Aim Study. In this study, impact autophagy apoptosis was studied through AMPK/SIRT1 pathway....

The present study aimed to investigate the expression of glucose-regulated protein 78 (GRP78) in osteosarcoma cells, and analyze differences between tumor normal tissues, pre- post-chemotherapy patients metastatic non-metastatic tumors. According these results, associations GRP78 growth, metastasis chemotherapeutics could be determined. Between 2007 2012, 60 who had been diagnosed with were selected for study. Of patients, 20 presented tumors 40 tumors, treated without chemotherapy...